Lipid peroxidation and antioxidant defense in chronic atrophic gastritis associated with Helicobacter pylori


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Chronic atrophic gastritis (CAG) is a precancerous disease of the stomach. According to Correa’s cascade, atrophic gastritis associated with Helicobacter pylori (Hp) can contribute not only to the occurrence, but also to the progression of metaplasia, dysplasia in the epithelial cells of the gastric mucosa, and to the transformation of these changes into gastric cancer. The risk of developing cancer increases by 15 times in CAG. Lipid peroxidation (LPO) is a process of oxidative degradation of lipids by free radicals. The results of LPO are balanced by the antioxidant defense (AOD) system. The objective of the investigation was to study LPO-AOD values in Hp-associated CAG.

Full Text

Restricted Access

About the authors

O. Smirnova

Research Institute for Medical Problems of the North, Federal Research Center «Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences»

V. Tsukanov

Research Institute for Medical Problems of the North, Federal Research Center «Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences»

A. Sinyakov

Research Institute for Medical Problems of the North, Federal Research Center «Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences»

O. Moskalenko

Research Institute for Medical Problems of the North, Federal Research Center «Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences»

Candidate of Biological Sciences

N. Elmanova

Research Institute for Medical Problems of the North, Federal Research Center «Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences»

E. Ovcharenko

Research Institute for Medical Problems of the North, Federal Research Center «Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences»

N. Titova

Siberian Federal University

Candidate of Biological Sciences

References

  1. Бордин Д.С., Машарова А.А., Хомерики С.Г. Хронический гастрит: современный взгляд на старую проблему // Эксперим. и клин. гастроэнтерол. - 2012; 5: 99-106. URL: https://cyberleninka.ru/article/v/hronicheskiy-gastrit-sovremennyy-vzglyad-na-staruyu-problemu
  2. Вернигородский С.В. Особенности структурных изменений слизистой оболочки желудка при хроническом гастрите у лиц разных возрастных групп // Клин. и эксперим. морфол. - 2014; 1 (9): 4-7
  3. Волкова Н.Н. Факторы риска развития хронического атрофического гастрита (литературный обзор) // Рус. мед. журн. - 2013; 21 (31): 1617-20
  4. Лазебник Л.Б., Васильев Ю.В., Щербаков П.Л. и др. Helicobacter pylori: распространенность, диагностика, лечение // Эксперим. и клин. гастроэнтерол. - 2010; 2: 3-7
  5. Смирнова О.В., Титова Н.М., Елманова Н.Г. Особенности прооксидантной и антиоксидантной системы у больных множественной миеломой в зависимости от стадии заболевания // Бюлл. эксперим. биологии и медицины. - 2014; 157 (3): 357-61
  6. Смирнова О.В., Титова Н.М., Манчук В.Т. и др. Особенности цитокиновой регуляции у больных механической желтухой различного генеза // Современные проблемы науки и образования. - 2015; 4: 425
  7. Павлович И.М., Гордиенко А.В., Бацков С.С. и др. Влияние Helicobacter pylori на морфологическое состояние слизистой оболочки желудка при хроническом гастрите// Медико- биологические и социально-психологические проблемы безопасности в чрезвычайных ситуациях. - 2013; 2: 32-5. https://doi.org/10.25016/2541-7487-2013-0-2-58-65.
  8. Скворцов В.В., Скворцова Е.М. Актуальные вопросы диагностики и лечения антрального гастрита типа // Поликлиника. - 2012; 1.1: 102-6
  9. Степанов Ю.М., Симонова Е.В. Повышение информативности эндоскопической диагностики предраковых изменений и рака желудка у больных с атрофическим гастритом // Гастроэнтерология. - 2013; 4 (50): 23-33
  10. Adamu M., Weck M., Rothenbacher D. et al. Incidence and risk factors for the development of chronic atrophic gastritis: five year follow up of a population based cohort study // Int. J. Cancer. - 2011; 128: 1652-8.
  11. Alakkari A., Zullo A., O’Connor H. Helicobacter pylori and Nonmalignant Diseases// Helicobacter. -2011; 16 (1): 33-7. doi: 10.1111/j.1523-5378.2011.00878.x.
  12. Correa P. Gastric cancer: overview // Gastroenterol. Clin. North. Am. - 2013; 42 (2): 211-7. doi: 10.1016/j.gtc.2013.01.002.
  13. Dinis-Ribeiro M., Areia M., de Vries A. et al. Management of precancerous conditions and lesions in the stomach (MAPS): guideline from the European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter Study Group (EHSG), European Society of Pathology (ESP), and the Sociedade Portuguesa de Endoscopia Digestiva (SPED) // Endoscopy. - 2012; 44 (1): 74-94. http://dx.doi. org/10.1055/s-0031-1291491.
  14. Graham D. Helicobacter pylori update: gastric cancer, reliable therapy, and possible benefits // Gastroenterology. - 2015; 148 (4): 719-31. DOI: 10.1053/j. gastro.2015.01.040.
  15. Hunt R., Xiao S., Megraud F.et al. Helicobacter Pylori in developing countries. World Gastroenterology Organisation Global Guideline // J. Gastrointestin. Liver Dis. - 2011; 20 (3): 299-304.
  16. Lee Y., Chen T., Chiu H. et al. The benefit of mass eradication of Helicobacter pylori infection: a community-based study of gastric cancer prevention // Gut. - 2013; 62 (5): 676-82. doi: 10.1136/gutjnl-2012-302240.
  17. Tonkic A., Tonkic M., Lehours P. et. al. Epidemiology and diagnosis of Helicobacter pylori infection // Helicobacter. - 2012; 17 (1): 1-8. doi: 10.1111/j.1523-5378.2012.00975.x.
  18. Wang J., Xu L., Shi R. et al. Gastric atrophy and intestinal metaplasia before and after Helicobacter pylori eradication: a meta-analysis // Digestion. - 2011; 83 (4): 253-60. doi: 10.1159/000280318
  19. Watari J., Chen N., Amenta P. et al. Helicobacter pylori associated chronic gastritis, clinical syndromes, precancerous lesions, and pathogenesis of gastric cancer development // World J. Gastroenterol. - 2014; 20 (18): 5461-73. doi: 10.3748/wjg.v20.i18.5461.
  20. Yoshida T. et al. Cancer development based on chronic active gastritis and resulting gastric atrophy as assessed by serum levels of pepsinogen and Helicobacter pylori antibody titer // Int. J. Cancer. - 2014; 134 (6): 1445-57. doi: 10.1002/ijc.28470.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2019 Russkiy Vrach Publishing House

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies