The indices of gastric mucosal epithelial cell proliferation and apoptosis in Helicobacter pylori-positive duodenal ulcer in the native inhabitants of the Republic of Tuva


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Abstract

Objective: to study the indices of gastric mucosal epithelial cell proliferation and apoptosis in Helicobacter pylori-positive duodenal ulcer (DU) in the native inhabitants of the Republic of Tuva. Methods. In the Republic of Tuva, during a clinical and epidemiological study, an immunohistochemical study of gastric mucosal epithelial cells was performed to identify the markers of proliferation (Ki-67 and PCNA) and apoptosis (bcl-2 and p53) in 32 Tuvans (15 men and 17 women; mean age, 47.7years) with Hp-positive DU and 24 Hp-positive Tuvans (12 men and 12 women; mean age, 46.4 years) without DU. Results. The apoptotic indices (bcl-2 and p53) did not differ significantly when comparing the patients with DU and the control group. The epithelial cell proliferation markers (Ki-67 and PCNA) and regulatory coefficients (proliferative/ apoptotic indices) were significantly higher in the patients with DU than in those without DU. Conclusion. The indigenous inhabitants of the Republic of Tuva show a shift in the gastric epithelial cell proliferative-apoptotic relationships towards a higher proliferative activity in patients with Hp-associated DU than in those without DU who have Hp infection.

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About the authors

V. V Tsukanov

Research Institute for Medical Problems of the North (Separate Subdivision), Federal Research Center «Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences»

Email: gastro@impn.ru
Professor, MD Krasnoyarsk

O. V Peretyatko

Research Institute for Medical Problems of the North (Separate Subdivision), Federal Research Center «Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences»

Email: gastro@impn.ru
Candidate of Medical Sciences Krasnoyarsk

A. S Pulikov

Research Institute for Medical Problems of the North (Separate Subdivision), Federal Research Center «Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences»

Email: gastro@impn.ru
Professor, MD Krasnoyarsk

A. V Vasyutin

Research Institute for Medical Problems of the North (Separate Subdivision), Federal Research Center «Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences»

Email: gastro@impn.ru
Candidate of Medical Sciences Krasnoyarsk

Yu. L Tonkikh

Research Institute for Medical Problems of the North (Separate Subdivision), Federal Research Center «Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences»

Email: gastro@impn.ru
Candidate of Medical Sciences Krasnoyarsk

T. V Polivanova

Research Institute for Medical Problems of the North (Separate Subdivision), Federal Research Center «Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences»

Email: gastro@impn.ru
MD Krasnoyarsk

V. A Vshivkov

Research Institute for Medical Problems of the North (Separate Subdivision), Federal Research Center «Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences»

Email: gastro@impn.ru
Candidate of Medical Sciences Krasnoyarsk

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