Investigation of resection margins during organ-sparing operations in patients with breast cancer


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Abstract

Objective: to improve relapse-free survival in patients with breast cancer (BC) after organ-sparing surgery (OSS). Subjects and methods. BC occupies a leading place in the pattern of malignant neoplasms among women worldwide and is one of the most important medical and socioeconomic problems. The treatment of BC is complex; however, the mainstay of therapy is surgery. As time elapses, surgical options have evolved from mutilating mastectomies to OSS. Today, oncoplastic resections (OPR) are widely used in oncological practice. Intraoperative assessment of resection margins is important for OSS and OPR. The presence of tumor cells in the resection margins is known to be one of the major factors in the development of local recurrence in patients with BC after OSS. The standard is the surgical practice of creating clean resection margins by re-excision. There are a huge number of publications describing the features of OSS and OPR, but without a detailed depiction of how to mark the resection margins. The development of a unified standard for the morphopathological assessment of operative material and its analysis will ultimately lead to a clearer definition of the relationship between resection margins and local recurrences, which will help decline the number of reoperations.

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About the authors

F. S Khugaeva

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: hugаevаf@mаil.ru

E. A Rasskazova

P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Radiology Research Center

Candidate of Medical Sciences

V. V Efanov

P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Radiology Research Center

Candidate of Medical Sciences

A. V Tregubova

P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Radiology Research Center

D. R Ortabaeva

P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Radiology Research Center

D. F Omarova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

N. N Volchenko

P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Radiology Research Center

MD

I. V Reshetov

P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Radiology Research Center; I.M. Sechenov First Moscow State Medical University (Sechenov University)

Professor, Academician of the Russian Academy of Sciences, MD

A. D Zikiryakhodzhaev

P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Radiology Research Center; I.M. Sechenov First Moscow State Medical University (Sechenov University); Peoples’ Friendship University of Russia

MD

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