MAIN GROUPS OF PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 INHIBITORS: MECHANISMS OF ACTION AND CLINICAL EFFICACY. PART 2


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Abstract

The proprotein convertase subtilisin-kexin type 9 (PCSK9) is considered a promising therapeutic target for the development of new drug groups aimed at the treatment and prevention of dyslipidemia and cardiovascular diseases (CVD). This article is a continuation of the earlier discussion of the main groups of PCSK9 inhibitors. The article discusses in detail the mechanisms of action and clinical efficacy of the following groups of drugs: low-molecular-weight PCSK9 inhibitors, mimetic peptides, and PCSK9 vaccines.

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About the authors

A. M Chaulin

Samara Regional Cardiology Dispensary; Samara State Medical University

Email: alekseymichailovich22976@gmail.com
Samara

N. A Svechkov

Samara Regional Cardiology Dispensary; Samara State Medical University

Samara

S. L Volkova

Samara Regional Cardiology Dispensary

Samara

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