Impact of thymalin on the values of cells, humoral immunity and the life quality in elderly patients with COVID-19


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Abstract

Often elderly people have severe course of COVID-19 and fast decreasing antibody concentration IgG to SARS-CoV-2. The severe course of COVID-19 may lead to decrease of the life quality and social maladjustment of older age parsons. Thymalin is the immunomodulatory peptide drug with physiological mechanism of activity. The goal of the investigation is to estimate the thymalin influence on the immunogram indicators and antibody IgG к SARS-CoV-2 concentration in elderly patients with COVID-19 on 200th day after treatment. Methods. The control group includes 50 elderly patients with COVID-19 on the standard treatment. The base group consists of 38 elderly patients with COVID-19 on the standard treatment with thymalin applying. Results. It was shown the decreasing of IL-6 blood concentration in 5.95 times to norm level and increasing the number of lymphocytes, CD3+, CD4+ cells in 2.15, 1.95 and 3.73 times to norm level after the standard treatment with thymalin applying in elderly patients with COVID-19 on the 200th day after treatment. The standard therapy has no the same effects. The level of IgG antibody to SARS-CoV-2 on the 200th day after the thymalin applying in addition to the standard treatment was in 4.25 times higher in comparison with this parameter in standard therapy group. Conclusion. The thymalin applying in addition to the standard treatment in elderly patients with COVID-19 normalizes immunogram indicators and prolongs during 200 days the safety high antibody concentration of IgG to SARS-CoV-2, which prevent reinfection. At the same time antibody level of IgG to SARS-CoV-2 in the standard treatment group practically disappeared to the 200th days after hospitalization.

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About the authors

V. Kh Khavinson

Saint Petersburg Institute of Bioregulation and Gerontology; Pavlov Institute of Physiology of the Russian Academy of Sciences

B. I Kuznik

Chita State Medical Academy

S. A Rukavishnikova

Saint Petersburg City Multiprofile hospital Second; Pavlov First Saint Petersburg State Medical University

S. V Trofimova

Saint Petersburg Institute of Bioregulation and Gerontology; Academy of Postgraduate Education, Federal Research and Clinical Center for Specialized Types of Medical Care and Medical Technologies, Federal Biomedical Agency of Russia

N. S Linkova

Saint Petersburg Institute of Bioregulation and Gerontology; Academy of Postgraduate Education, Federal Research and Clinical Center for Specialized Types of Medical Care and Medical Technologies, Federal Biomedical Agency of Russia; Belgorod National Research University

T. A Akhmedov

Saint Petersburg City Multiprofile hospital Second; Pavlov First Saint Petersburg State Medical University

V. V Bashuk

Belgorod National Research University

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