Impact on the quality of life of the features of calcium-phosphorus relationships in tumor growth in old age

The quality of life in oncological pathology is an important criterion for the effectiveness of the treatment. One of the key issues is the change in metabolism in the elderly and senile age. This aspect is directly related to the state of the elements. The age-related pathology can also include endocrinopathies, including those with oncological pathology of the endocrine organs. The aim of the study was to develop new approaches to the study of age-associated disorders in individuals with cancer pathology with the study of phosphorus-calcium relationships for their further correction with the goal of improving the quality of life of such patients. We selected 40 cases of prostate adenocarcinoma of the 2nd and 3rd degree in middle-aged and elderly people and 47 cases of papillary thyroid cancer. A clinical and pathomorphological study of the removed thyroid and pancreas was performed (macroscopic, microscopic, electron microscopic in a scanning microscope «FE1 Quanta 200 3D» with a matched detector for the study of elemental analysis). When studying the biochemical atypism in pancreatic and thyroid cancers using point analysis of elements, it was shown that in the areas of accumulation of tumor cells, there was an increase in the content of both calcium and phosphorus, which decreases as they move away from them. Given that their content is higher in the elderly groups and atypical cells are not always identified next to them, it seems that their formation may be primary. The presence of histochemical atypism in the glands can cause the development of paraneoplastic syndromes, in particular, increased osteoporosis in the elderly and a number of other signs. All this should be taken into account when correcting such conditions in order to improve the quality of life.

quality of life, geriatrics, oncology, elements, endocrinopathy