The possibilities of using a biologically active supplement SELENBIO for women in cases of reproductive health disorders

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The review of information on the effect of the trace element selenium (Se) on reproductive health, pregnancy and lactation was carried out. The article presents research data showing that an increased need for Se is noted during pregnancy and lactation, and selenium deficiency leads to disorders of the reproductive system, complications of pregnancy and childbirth, and the development of disorders in the fetus. It has been shown that the use of SELENBIO for women dietary supplement containing selenium, zinc, vitamins C and E can be a way to prevent Se deficiency.

Full Text

Restricted Access

About the authors

T. V Potupchik

V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia

Email: potupchik_tatyana@mail.ru

Candidate of Medical Sciences

Russian Federation,

E. V Okladnikova

V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia

Email: potupchik_tatyana@mail.ru

Candidate of Medical Sciences

Russian Federation,

O. F Veselova

V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia

Email: potupchik_tatyana@mail.ru

Candidate of Medical Sciences

Russian Federation,

T. V Dresvyanskaya

Krasnoyarsk Interdistrict Clinical Hospital Four

Author for correspondence.
Email: potupchik_tatyana@mail.ru
Russian Federation,

References

  1. Борисов В.В. Микроэлементы селен и цинк в организме женщины и мужчины: проблемы и решения. Consilium Medicum. 2018; 20 (7): 63-8 doi: 10.26442/2075-1753_2018.7.63-68
  2. Голубкина Н.А. Селен в медицине и экологии. М.: КМК, 2002
  3. Дедов Д.В. Cелен и селенсодержащие препараты: значение для организма и профилактики различных заболеваний. Фармация. 2021; 70 (8): 54-7 doi: 10.29296/25419218-2021-08-09
  4. Ключников С.О., Дещекина М.Ф., Демин В.Ф. Минеральный состав сыворотки крови новорожденных в раннем неонатальном периоде. Педиатрия. 1995; 3: 28-32
  5. Ключников С.О., Дещекина М.Ф., Демин В.Ф. Содержание макро- и микроэлементов в сыворотке крови новорожденных как один из критериев оценки состояния при рождении. Педиатрия. 1994; 6: 53-5
  6. Полубояринов П.А. Исследование биофортификации растений астрагала Астрагала шерстистоцветкового (Astragalus dasyanthus Pall.) аминокислотой L-селеноцистеином. Вопросы биологической, медицинской и фармацевтической химии. 2019; 22 (12): 64 URL: https://www.secret-dolgolet.ru/ biofortifikatsiya-rasteniy-astragala-sherstistotsvetkovogo-astragalus-dasyanthus-pall-aminokislotoy-l-selenotsistinom/
  7. Полубояринов П.А., Елистратов Д.Г., Швец В.И. Метаболизм и механизм токсичности селенсодержащих препаратов, используемых для коррекции дефицита микроэлемента селена. Тонкие химические технологии. 2019; 14 (1): 5-24 doi: 10.32362/2410-6593-2019-14-1-5-24
  8. Сенькевич О.А. Комарова З.А. Дефицит селена в преконцепции и лактации: последствия и пути коррекции. Дальневосточный медицинский журнал. 2016; 2: 42-6
  9. Тутельян В.А., Княжев В.А., Хотимченко С.А. и др. Селен в организме человека: метаболизм, антиоксидантные свойства, роль в канцерогенезе. М.: РАМН, 2002
  10. Тутельян В.А., Мазо В.К., Ширина Л.И. Значение селена в полноценном питании человека. Гинекология. 2002; 4 (2): 88-90
  11. Шилин Д.Е., Спиричев В.Б. Минеральный гомеостаз и костный метаболизм в организме беременной, плода, ребенка. Остеопороз и остеопатии. 2006; 6: 26-31
  12. Alexander J., Tinkov A., Strand T.A. et al. Early Nutritional Interventions with Zinc, Selenium and Vitamin D. for Raising Anti-Viral Resistance Against Progressive COVID-19. Aaseth J.Nutrients. 2020; 12 (8): 2358. DOI: 10.3390/ nu12082358
  13. Al-Sheikh Y.A., Al-Zahrani K.Y. The Status of Biochemical and Molecular Markers of Oxidative Stress in Preeclamptic Saudi Patients. Curr Mol Med. 2018; 18 (7): 475-85. doi: 10.2174/1566524019666190104105843
  14. Barrington J.W., Linsay P., James D. et al. Selenium deficiency and miscarriage: a possible link? Br J. Obstet Gynaecol. 1996; 103 (2): 130-2. doi: 10.1111/j.1471-0528
  15. Beno I., Ondreicka R., Magalova T. et al. Precancerous conditions and carcinomas of the stomach and colorectum-blood levels of selected micronutrients. Bratisl Lek Listy. 1997; 98 (12): 674-7.
  16. Bouvier N., Millart H. Relationships between selenium deficiency and 3,5,3’-triiodothyronine (T3) synthesis. Ann Endocrinol (Paris). 1997; 58 (4): 310-5.
  17. Daniels L., Gibson R.A., Simmer K. et al. Selenium status of term infants fed selenium-supplemented formula in a randomized dose-response trial. Am J. Clin Nutr. 2008; 88 (1): 70-6. doi: 10.1093/ajcn/88.1.70
  18. Dodge M.L., Wander. R.C., Xia Y. et al. Glutathione peroxidase activity modulates fatty acid profiles of plasma and breast milk in Chinese women. J. Trace Elem Med Biol. 1999; 12 (4): 221-30. doi: 10.1016/S0946-672X(99)80062-5
  19. Dorea J.G. Selenium and breast-feeding. Br J. Nutr. 2002;88 (5): 443-61. doi: 10.1079/BJN2002692
  20. Duntas L.H. Selenium and at-risk pregnancy: challenges and controversies. Thyroid Res. 2020; 13: 16. doi: 10.1186/s13044-020-00090-x
  21. Flohe L. Selenium in peroxide metabolism. Med Klin. 1997; 92 (3): 5-7. doi: 10.1007/BF03041948
  22. Gac P., Czerwinska K., Macek P. et al. The importance of selenium and zinc deficiency in cardiovascular disorders. Environ Toxicol Pharmacol. 2021; 82: 103553. doi: 10.1016/j.etap.2020.103553
  23. Heidar Z., Hamzepour N., Modarres S.Z. et al. The Effects of Selenium Supplementation on Clinical Symptoms and Gene Expression Related to Inflammation and Vascular Endothelial Growth Factor in Infertile Women Candidate for In Vitro Fertilization. Biol Trace Elem Res. 2020; 193 (2): 319-25. DOI: 10.1007/ s12011-019-01715-5.
  24. Hung T.H., Lo L.M., Chiu T.H. et al. A longitudinal study of oxidative stress and antioxidant status in women with uncomplicated pregnancies throughout Gestation. Reprod Sci. 2010; 17 (4): 401-9. doi: 10.1177/1933719109359704
  25. Huang X., Dong Y.L., Li T. et al. Dietary Selenium Regulates microRNAs in Metabolic Disease: Recent Progress. Nutrients. 2021; 13 (5): 1527. DOI: 10.3390/ nu13051527
  26. Kvicala J., Zamrazil V., Soutorova M. et al. Correlations between parameters of body selenium status and peripheral thyroid parameters in the low selenium region. Analyst. 1995; 120 (3): 959-65. doi: 10.1039/an9952000959
  27. Lee A.S.E., Ji Y., Raghavan R. et al. Maternal prenatal selenium levels and child risk of neurodevelopmental disorders: A prospective birth cohort study. Autism Res. 2021; 14 (12): 2533-43. doi: 10.1002/aur.2617
  28. Lewandowska M., Sajdak S., Lubinski J. Serum selenium level in early healthy pregnancy as a risk marker of pregnancy induced hypertension. Nutrients. 2019; 11 (5): 1028. doi: 10.3390/nu1105102
  29. Lorenzetti S., Plösch T., Teller I.C. Antioxidative molecules in human milk and environmental contaminants. Antioxidants. 2021; 10: 550. DOI: 10.3390/ antiox10040550
  30. Mantovani G., Isidori A.M., Moretti C. et al. Selenium supplementation in the management of thyroid autoimmunity during pregnancy: results of the «SERENA study», a randomized, double-blind, placebo-controlled trial. Endocrine. 2019; 66 (3): 542-50. doi: 10.1007/s12020-019-01958-1
  31. Mehdi Y., Hornick J.L., Istasse L. et al. Selenium in the environment, metabolism and involvement in body functions. Molecules. 2013; 18: 3292-311. doi: 10.3390/molecules18033292
  32. Mihailovic M., Cvetkovic M., Ljubic A. et al. Selenium and malonidialdehyde content and glutathione peroxidase activity in maternal and umbilical cord blood and amniotic fluid. Biol Trace Elem Res. 2000; 73 (1): 47-54. DOI: 10.1385/ BTER:73:1:47
  33. Mirnamniha M., Faroughi F., Tahmasbpour E. et al. An overview on role of some trace elements in human reproductive health, sperm function and fertilization process. Rev Environ Health. 2019; 34 (4): 339-48. DOI: 10.1515/ reveh-2019-0008
  34. Mistry H.D., Pipkin F.B., Redman C.W.G. et al. Selenium in reproductive health. Am J. Obstet Gynecol. 2012; 206 (1): 21-30. DOI: 10.1016/j. ajog.2011.07.034
  35. Mojadadi A., Au A., Salah W. et al. Role for Selenium in Metabolic Homeostasis and Human Reproduction. Nutrients. 2021; 13 (9): 3256. doi: 10.3390/nu13093256
  36. Mostafa-Gharehbaghi M., Mostafa-Gharabaghi P., Ghanbari F. et al. Determination of selenium in serum samples of preterm newborn infants with bronchopulmonary dysplasia using a validated hydride generation system. Biol Trace Elem Res. 2012; 147 (1-3): 1-7. doi: 10.1007/s12011-011-9270-z
  37. Na J.Y., Seok J., Park S. et al. Effects of selenium on the survival and invasion of trophoblasts. Clin Exp Reprod Med. 2018; 45 (1): 10-6. DOI: 10.5653/ cerm.2018.45.1.10
  38. Nikniaz L., Mahavi R., Ostadrahimi A. et al. Synbiotic supplementation is not effective on breast milk selenium concentrations and growth of exclusively breast fed infants: a pilot study. Int J. Vitam Nutr Res. 2019; 89 (1-2): 73-9. doi: 10.1024/0300-9831/a000549
  39. Oropeza-Moe M., Wisbff H., Bernhoft A. Selenium deficiency associated porcine and human cardiomyopathies. J. Trace Elem Med Biol. 2015; 31: 148-56. doi: 10.1016/j.jtemb.2014.09.011
  40. Pi X., Wei Y., Li Z. et al. Higher concentration of selenium in placental tissues is associated with reduced risk for orofacial clefts. Clin Nutr. 2019; 38 (5): 2442-8. doi: 10.1016/j.clnu.2018.11.002
  41. Pieczynska J., Grajeta H. The role of selenium in human conception and pregnancy. J. Trace Elem Med Biol. 2015; 29 (1): 31-8. DOI: 10.1016/j. jtemb.2014.07.003
  42. Qazi I.H., Angel C., Yang H. et al. Selenium, Selenoproteins, and Female Reproduction: A Review. Molecules. 2018; 23 (12): 3053. DOI: 10.3390/ molecules23123053
  43. Rashidi B.H., Hosseinzadeh F.M., Alipoor E. et al. Effects of Selenium Supplementation on Asymmetric Dimethylarginine and Cardiometabolic Risk Factors in Patients with Polycystic Ovary Syndrome. Biol Trace Elem Res. 2020; 196 (2): 430-7. doi: 10.1007/s12011-019-01954-6
  44. Rayman M.P. Selenium and human health. Lancet. 2012; 379 (9822): 1256-68. doi: 10.1016/S0140-6736(11)61452-9
  45. Rayman M.P., Bath S.C., Westaway J. et al. Selenium status in U.K. pregnant women and its relationship with hypertensive conditions of pregnancy. Br J. Nutr. 2015; 113 (2): 249-58. doi: 10.1017/S000711451400364X
  46. Rayman M.P., Searle E., Kelly L. et al. Effect of selenium on markers of risk of preeclampsia in UK pregnant women: a randomised, controlled pilot trial. Br J. Nutr. 2014; 112 (1): 99-111. doi: 10.1017/S0007114514000531
  47. Schomburg L., Orho-Melander M., Struck J. et al. Selenoprotein-P Deficiency Predicts Cardiovascular Disease and Death. Nutrients. 2019; 11 (8): 1852. doi: 10.3390/nu11081852
  48. Shahidi F., De Camargo A.C. Tocopherols and tocotrienols in common and emerging dietary sources: Occurrence, applications, and health benefits. Int J. Mol Sci. 2016; 17 (10): 1745. doi: 10.3390/ijms17101745
  49. Shimada B.K., Alfulaij N., Seale L.A. The Impact of Selenium Deficiency on Cardiovascular Function. Int J. Mol Sci. 2021; 22 (19): 10713. DOI: 10.3390/ ijms221910713
  50. Skröder H.M., Hamadani J.D., Tofail F. et al. Selenium status in pregnancy influences children’s cognitive function at 1.5 years of age. Clin Nutr. 2015; 34 (5): 923-30. doi: 10.1016/j.clnu.2014.09.020
  51. Song M., Kumaran M.N., Gounder M. et al. Phase I. trial of selenium plus chemotherapy in gynecologic cancers. Gynecol Oncol. 2018; 150 (3): 478-86. doi: 51.1016/j.ygyno.2018.07.001
  52. Tara F., Maamouri G., Rayman M.P. et al. Selenium supplementation and the incidence of preeclampsia in pregnant Iranian women: a randomized, doubleblind, placebo-controlled pilot trial. Taiwan J. Obstet Gynecol. 2010; 49 (2): 181-7. doi: 10.1016/S1028-4559(10)60038-1
  53. Tara F., Rayman M.P., Boskabadi H. et al. Selenium supplementation and premature (pre-labour) rupture of membranes: a randomised double-blind placebo-controlled trial. J. Obstet Gynaecol. 2010; 30 (1): 30-4. doi: 10.3109/01443610903267507
  54. Veisa V., Kalere I., Zake T. et al. Assessment of Iodine and Selenium Nutritional Status in Women of Reproductive Age in Latvia. Medicina (Kaunas). 2021; 57 (11): 1211. doi: 10.3390/medicina57111211
  55. Wąsowicz W., Wolkanin P., Bednarski M. et al. Plasma trace element (Se, Zn, Cu) concentration in maternal and umbilical cord blood in Poland. Biol Trace Elem Res. 1993; 38 (2): 205-15. doi: 10.1007/BF02784053
  56. Xu M., Guo D., Gu H. et al. Selenium and Preeclampsia: a Systematic Review and Meta-analysis. Biol Trace Elem Res. 2016; 171 (2): 283-92. doi: 10.1007/s12011-015-0545-7
  57. Zheng G.X., Lin J.T., Zheng W.H. et al. Energy intake, oxidative stress and antioxidant in mice during lactation. Dongwuxue Yanjiu. 2015;36: 95-102. doi: 10.13918/j.issn.2095-8137.2015.2.95

Supplementary files

Supplementary Files
Action
1. JATS XML

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies