Benign forgetfulness and dementia in old age groups

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Abstract

The paper considers the molecular mechanisms of emergence of short-term and long-term memory in the human cerebral cortex. It shows that short-term memory is due to an increase in the function of synaptic connections in the cerebral cortex, while long-term memory is due to the emergence of additional duplicate synaptic connections. Forgetting and remembering various concepts occurs due to the disruption and subsequent restoration of synaptic connections in the cyclic neuronal circuits of the neocortex. The principles of drug exposure in the development of dementia are assessed.

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About the authors

A. N Volobuev

Samara State Medical University

Email: volobuev47@yandex.ru

P. I Romanchuk

Samara State Medical University

Email: volobuev47@yandex.ru

кандидат медицинских наук

N. P Romanchuk

Samara State Medical University

Email: volobuev47@yandex.ru

кандидат медицинских наук

S. V Krasnov

Samara State Medical University

Email: volobuev47@yandex.ru

доктор биологических наук, профессор

I. L Davydkin

Samara State Medical University

Author for correspondence.
Email: volobuev47@yandex.ru

доктор медицинских наук, профессор

References

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  5. Бредесен Д. Нестареющий мозг. Глобальное медицинское открытие об истинных причинах снижения умственной активности, позволяющее обрести ясность ума, хорошую память и спасти мозг от болезни Альцгеймера. Пер. с англ. М.: ЭКСМО, 2019; 304 с.

Supplementary files

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2. Fig. 1. Scheme of the emergence of short-term and long-term memory in neocortical neurons (description in text)

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3. Fig. 2. Diagram of some processes in the neuronal synapse in the development of memory (description in text)

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