Possibilities and prospects of epigenetic rehabilitation in patients with external genital endometriosis

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Abstract

Epigenetics is a modern promising field that studies the activity of genes in response to environmental and lifestyle factors. Knowledge of epigenetic mechanisms, starting from intrauterine development, can expand the possibilities of timely treatment of external genital endometriosis, early prevention of relapses and carcinogenesis. The present review considers and systematizes data on the use of epigenetic mechanisms in rehabilitation based on the analysis of modern scientific medical literature, both domestic and foreign. This study showed that epigenetic mechanisms significantly affect the formation of external genital endometriosis and endometriosis-associated ovarian cancer. Standard therapy in combination with epigenetic rehabilitation will lead to a decrease in the recurrence of the disease and stabilization of the achieved results. Thus, it is crucially important to develop pathogenetically substantiated comprehensive rehabilitation schemes that will provide a personalized approach, timely prevention, prognosis and treatment of external genital endometriosis.

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About the authors

E. Begovich

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia

Author for correspondence.
Email: antoninasolopova@yandex.ru

A. G Solopova

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia

Email: antoninasolopova@yandex.ru

S. V Khlopkova

L.A. Vorokhobov City Clinical Hospital Sixty-Seven

Email: antoninasolopova@yandex.ru

A. Yu Vlaslna

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia

Email: antoninasolopova@yandex.ru

V. V Kuznetsova

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia

Email: antoninasolopova@yandex.ru

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