The use of probiotics in the combination treatment of patients with moderate acne

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Abstract

Acne is one of the most common skin diseases. Modern treatment regimens for this disease include, among other things, antibacterial drugs (ABP) for up to 8 weeks. However, the prescription of ABP entails the development of intestinal microbiocenosis disorders that can aggravate the course of the underlying disease. As far back as the 1930s, the gastroenterological mechanisms involved in the relationship between the status of the intestine and skin diseases were first stated, as well as it was also proposed to use probiotic cultures in the therapy of acne. In addition, modern researches have confirmed the aspects of the gut-brain-skin theory. Thus, the intestinal microflora and oral probiotics can be associated with the skin and, in particular, with the severity of acne due to their ability to influence systemic inflammation, oxidative stress, glycemic control, lipid content in tissues, etc. Our investigation shows the effectiveness of prescribing a probiotic in the treatment of moderate acne in patients taking doxycycline.

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About the authors

S. V. Klyuchereva

I.I. Mechnikov North-Western State Medical University Ministry of Health of Russia

Email: seliverstov-pv@yandex.ru

Professor, MD

Saint Petersburg

S. S. Ledentsova

City Polyclinic Seventy-Six Ministry of Health of Russia

Email: seliverstov-pv@yandex.ru
Saint Petersburg

V. G. Radchenko

S.M. Kirov Military Medical Academy Ministry of Defense of Russia

Email: seliverstov-pv@yandex.ru

Professor, MD

Saint Petersburg

P. V. Seliverstov

S.M. Kirov Military Medical Academy Ministry of Defense of Russia; V.A. Almazov National Medical Research Center Ministry of Health of Russia

Author for correspondence.
Email: seliverstov-pv@yandex.ru

Candidate of Medical Sciences

Saint Petersburg; Saint Petersburg

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Supplementary files

Supplementary Files
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2. Fig. 1. Impaired intestinal microbiocenosis in patients with moderate acne before treatment (n=108)

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3. Fig. 2. The results of fecal bacteria tests in Groups 1 and 2 at baseline and 4 weeks after treatment

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4. Fig. 3. Distribution of Group 1 patients according to the degree of dysbiosis at baseline and 4 weeks after treatment

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5. Fig. 4. Distribution of Group 2 patients according to the degree of dysbiosis at baseline and 4 weeks after treatment

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6. Fig. 5. Symptoms of gastric dyspepsia in Group 1 patients at baseline and 4 weeks after treatment

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7. Fig. 6. Symptoms of intestinal dyspepsia in Group 1 patients at baseline and 4 weeks after treatment

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8. Fig. 7. Quality of life indicators (according to the Short Form-36) in Groups 1 and 2 at baseline and 4 weeks after treatment

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