Current diagnostic criteria for AL amyloidosis

AL amyloidosis (AL-A) is an extremely heterogeneous disease in clinical manifestations with no pathognomonic symptoms. Early diagnosis and cytoreductive therapy allow most cases to achieve a positive effect and to stop the progression of organ dysfunction. There is a literature review of scientific information on modern methods for the diagnosis of systemic AL-A. Attention is drawn to the difficulties in diagnosis, as well as to the main clinical signs that make it possible to suspect this disease. Consideration is given to the international criteria confirming the diagnosis and prevalence of the process, as well as prognostic staging systems. The timely diagnosis of AL-A is the most important task for physicians of various specialties, who see these patients at the first stages