Chaga birch mushroom: anti-inflammatory, antioxidant, immunomodulatory, antiviral effects, the possibility of using the Russian drug BioChaga in patients with novel coronavirus infection (COVID-19)

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Abstract

In the work performed: analysis of 28 publications from the People’s Republic of China, the Russian Federation, the United States, Great Britain, the Republic of Poland, Hungary, Serbia, the Republic of Korea, Portugal, the Netherlands, Saudi Arabia, Egypt, the Republic of South Africa. Reflected: anti-inflammatory, antioxidant, immunomodulatory, antiviral effect of birch chaga mushroom. Showed: a wide range of antiviral action of birch chaga mushroom. Presented: research on the effectiveness of the use of chaga in coronovirus infection. Studied: the possibility of using the Russian drug BioChaga in patients with novel coronavirus infection (COVID-19).

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About the authors

D. V. Dedov

Tver State Medical University; Tver Regional Clinical Cardiology Dispensary

Author for correspondence.
Email: dedov_d@inbox.ru

доктор медицинских наук, профессор

O. N. Usolceva

Irkutsk State Medical University

Email: dedov_d@inbox.ru

кандидат медицинских наук

References

  1. Kou R.W., Han R., Gao Y.Q. et al. Anti-neuroinflammatory polyoxygenated lanostanoids from Chaga mushroom Inonotus obliquus. Phytochemistry. 2021; 184: 112647. DOI: 10.1016/j. phytochem.2020.112647
  2. Szychowski K.A., Skora B., Pomianek T. et al. Inonotus obliquus - from folk medicine to clinical use. J. Tradit Complement Med. 2021; 11 (4): 293-302. doi: 10.1016/j.jtcme.2020.08.003
  3. Teplyakova T.V., Ilyicheva T.N., Kosogova T.A. et al. Medicinal Mushrooms against Influenza Viruses. Int J. Med Mushrooms. 2021; 23 (2): 1-11. doi: 10.1615/IntJMedMushrooms.2020037460
  4. Носик Д.Н., Носик Н.Н., Теплякова Т.В. и др. Противовирусная активность экстрактов базидиомицетов и гуминовых соединений в отношении вируса иммунодефицита человека (Retroviridae: Orthoretrovirinae: Lentivirus: Human immunodeficiency virus 1) и вируса простого герпеса (Herpesviridae: Simplexvirus: Human alphaherpesvirus 1). Вопросы вирусологии. 2020; 65 (5): 276-83. doi: 10.36233/0507-4088-2020-65-5-4
  5. Teplyakova Т., Pyankov O., Safatov A.et al. Water Extract of the Chaga Medicinal Mushroom, Inonotus obliquus (Agaricomycetes), Inhibits SARS-CoV-2 Replication in Vero E6 and Vero Cell Culture Experiments. Int J. Med Mushrooms. 2022; 24 (2): 23-30. doi: 10.1615/IntJMedMushrooms.2021042012
  6. Shahzad F., Anderson D., Najafzadeh M. The Antiviral, Anti-Inflammatory Effects of Natural Medicinal Herbs and Mushrooms and SARS-CoV-2 Infection. Nutrients. 2020; 12 (9): 2573. doi: 10.3390/nu12092573
  7. Cui Y., Kim D.S., Park K.C. Antioxidant effect of Inonotus obliquus. J. Ethnopharmacol. 2005; 96 (1-2): 79-85. doi: 10.1016/j.jep.2004.08.037
  8. Усольцева О.Н., Оленников Д.Н., Потупчик Т. В. Оценка качества и биологической активности экстракта березового гриба чага «БиоЧага». Фармация. 2022; 71 (2): 33-40. doi: 10.29296/25419218-2022-02-06
  9. Lu Y., Jia Y., Xue Z. et al. Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application. Polymers (Basel). 2021; 13 (9): 1441. doi: 10.3390/polym13091441
  10. Glamoclija J., Ciric A., Nikolic M. et al. Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal «mushroom». J. Ethnopharmacol. 2015; 162: 323-32. doi: 10.1016/j.jep.2014.12.069
  11. Змитрович И.В., Денисова Н.П., Баландайкин М.Э. и др. Чага и ее биоактивные комплексы: история и перспективы. Формулы фармации. 2020; 2 (2): 84-93. doi: 10.17816/phf34803
  12. Duru K.C., Kovaleva E.G., Danilova I.G. et al. The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies. Phytother Res. 2019; 33 (8): 1966-80. doi: 10.1002/ptr.6384
  13. Теплякова Т.В., Косогова Т.А., Андреева И.А. и др. Антивирусная, антибактериальная и антигрибковая активность компонентов трутовика скошенного, чаги Inonotus obliquus (Fr.) Pil. Успехи медицинской микологии. 2019; 20: 535-40.
  14. Усольцева О.Н. Профилактика ускоренного старения и «болезней цивилизации» с помощью природных геропротекторов БиоЧага и БиоДигидрокверцетин. Медицинская сестра. 2022; 3: 34-40. doi: 10.29296/25879979-2022-03-07
  15. Garadi Z., Dekany M., Moricz A.M. et al. Antimicrobial, Antioxidant and Antiproliferative Secondary Metabolites from Inonotus nidus-pici. Molecules. 2021; 26 (18): 5453. doi: 10.3390/molecules26185453
  16. Szychowski K.A., Skora B., Pomianek T. et al. Inonotus obliquus - from folk medicine to clinical use. J. Tradit Complement Med. 2020; 11 (4): 293-302. DOI: 10.1016/j. jtcme.2020.08.003
  17. Park Y.M., Won J.H., Kim Y.H. et al. In vivo and in vitro anti-inflammatory and antinociceptive effects of the methanol extract of Inonotus obliquus. J. Ethnopharmacol. 2005; 101 (1-3): 120-8. doi: 10.1016/j.jep.2005.04.003
  18. Fan L., Ding S., Ai L. et al. Antitumor and immunomodulatory activity of water-soluble polysaccharide from Inonotus obliquus. Carbohydr Polym. 2012; 90 (2): 870-4. DOI: 10.1016/j. carbpol.2012.06.013
  19. Niu H., Song D., Mu H. et al. Investigation of three lignin complexes with antioxidant and immunological capacities from Inonotus obliquus. Int J. Biol Macromol. 2016; 86: 587-93. doi: 10.1016/j.ijbiomac.2016.01.111
  20. Liu Z., Yu D., Li L. et al. Three-Phase Partitioning for the Extraction and Purification of Polysaccharides from the Immunomodulatory Medicinal Mushroom Inonotus obliquus. Molecules. 2019; 24 (3): 403. doi: 10.3390/molecules24030403
  21. Won D.P., Lee J.S., Kwon D.S. et al. Immunostimulating activity by polysaccharides isolated from fruiting body of Inonotus obliquus. Mol Cells. 2011; 31 (2): 165-73. doi: 10.1007/s10059-011-0022-x
  22. Guo Y., Chen X., Gong P. Classification, structure and mechanism of antiviral polysaccharides derived from edible and medicinal fungus. Int J. Biol Macromol. 2021; 183: 1753-73. doi: 10.1016/j.ijbiomac.2021.05.139
  23. Shahzad F., Anderson D., Najafzadeh M. The Antiviral, Anti-Inflammatory Effects of Natural Medicinal Herbs and Mushrooms and SARS-CoV-2 Infection. Nutrients. 2020; 12 (9): 2573. doi: 10.3390/nu12092573
  24. Huang C., Wang Y., Li X. et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020; 395 (10223): 497-506. doi: 10.1016/S0140-6736(20)30183-5
  25. Zhang J., Zhou L., Yang Y. et al. Therapeutic and triage strategies for 2019 novel coronavirus disease in fever clinics. Lancet Respir Med. 2020; 8 (3): e11-12. doi: 10.1016/S2213-2600(20)30071-0
  26. Xu Z., Li S., Tian S. et al. Full spectrum of COVID-19 severity still being depicted. Lancet. 2020; 395 (10228): 947-8. doi: 10.1016/S0140-6736(20)30308-1
  27. Elshemey W.M., Elfiky A.A., Ibrahim I.M. et al. Interference of Chaga mushroom terpenoids with the attachment of SARS-CoV-2; in silico perspective. Comput Biol Med. 2022; 145: 105478. doi: 10.1016/j.compbiomed.2022.105478
  28. Усольцева О.Н. Эффективные природные средства БиоЧага и БиоДигидрокверцетин для безопасной помощи организму на всех этапах вирусной инфекции COVID-19. Медицинская сестра. 2022; 2: 20-2. doi: 10.29296/25879979-202202-05

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