COLORECTAL CANCER IN OBESITY: PATHOGENETIC ASPECTS

The recent studies that prove the role of obesity as a risk factor for colorectal cancer have been analyzed. Obesity-related evolving imbalance in the adipose tissue production of adipokines favors the development and maintenance of systemic inflammatory response, insulin resistance, hyperglycemia, and hyperinsulinemia. By affecting each other, these conditions impair the gene regulation of a normal cell cycle through the intracellular signaling pathway system, by contributing to malignant transformation of the colonic mucosa, and create favorable conditions for tumor cell survival and proliferation.

metabolic syndrome, obesity, colorectal cancer, insulin resistance, systemic inflammatory response