DIFFICULT CHOICE OF β-ADRENOBLOCKERS IN CLINICAL PRACTICE


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详细

Β-Adrenoblockers (β-ABs) have proved their efficacy and relative safety. The basic effects of block of β-ABs located in all smooth muscle fibers, including those in the vessel wall, are antihypertensive, anti-ischemic, antioxidant, and antiarrhythmic. The lipophilic cardioselective β-blocker nebivolol holds a special place among β-ABs. There is evidence for its high efficacy in correcting endothelial dysfunction in patients with arterial hypertension and coronary heart disease and for its antiatherosclerotic properties associated with its ability to normalize the synthesis of endothelial nitric oxide.

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作者简介

E. Bulanova

I.M. Sechenov First Moscow State Medical University

Candidate of Medical Sciences

O. Drapkina

I.M. Sechenov First Moscow State Medical University

Email: drapkina@bk.ru
Professor, MD

I. Popova

I.M. Sechenov First Moscow State Medical University

Candidate of Medical Sciences

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