USE OF PANANGIN IN OUTPATIENTS WITH ARTERIAL HYPERTENSION DURING THE PERIOD OF SUMMER HEAT


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The effect of Panangin on electrolyte balance, a reaction of the cardiovascular system, psychological status, and quality of life (QL) was evaluated in patients with compensated arterial hypertension (AH) under hot summer conditions. The investigation enrolled 61 patients receiving therapy with antihypertensive drugs, including angiotensin-converting enzyme inhibitors (ACEI); Panangin (1 tablet thrice daily) was added to the basic therapy in 31 patients; other 30 patients formed a control group. During heat, all the patients in the Panangin group tended to diminish anxiety and to significantly improve QL, which were absent in the control group. The QL increment significantly correlated with the plasma concentrations of K+ and Mg++. The use of Panangin during the hot period, which gave rise to slightly raised systolic blood pressure and decreased heart rate, could promote better QL. According to the results of the investigation, Panangin may be used to improve QL in patients with compensated AH in the period of summer heat. The drug given in prophylactic doses is safe, including when it is used in combination with ACEI and in elderly patients.

Full Text

Restricted Access

About the authors

F. Ageyev

A.L. Myasnikov Research Institute of Cardiology, Russian Cardiology Research-and-Production Complex, Ministry of Health and Social Development

Email: ageev@cardio.ru
Professor, MD; Research Dispensary Department

M. Smirnova

A.L. Myasnikov Research Institute of Cardiology, Russian Cardiology Research-and-Production Complex, Ministry of Health and Social Development

Candidate of Medical Sciences; Research Dispensary Department

P. Galaninsky

A.L. Myasnikov Research Institute of Cardiology, Russian Cardiology Research-and-Production Complex, Ministry of Health and Social Development

Research Dispensary Department

O. Svirida

A.L. Myasnikov Research Institute of Cardiology, Russian Cardiology Research-and-Production Complex, Ministry of Health and Social Development

Candidate of Medical Sciences; Research Dispensary Department

A. Kuzmina

A.L. Myasnikov Research Institute of Cardiology, Russian Cardiology Research-and-Production Complex, Ministry of Health and Social Development

Candidate of Medical Sciences; Research Dispensary Department

I. Patrusheva

A.L. Myasnikov Research Institute of Cardiology, Russian Cardiology Research-and-Production Complex, Ministry of Health and Social Development

Candidate of Medical Sciences; Research Dispensary Department

E. Nurallyev

A.L. Myasnikov Research Institute of Cardiology, Russian Cardiology Research-and-Production Complex, Ministry of Health and Social Development

Candidate of Medical Sciences; Research Dispensary Department

References

  1. Climate change and communicable diseases in the EU Member States. Handbook for national vulnerability, impact and adaptation assessments. European Centre for Diseases Prevention and Control. - 2010; 42 p.
  2. Nicholson A., Fuhrer R., Marmot M. Psychological Distress as a Predictor of CHD Events in Men: The Effect of Persistence and Components of Risk // Psychosom. Med. - 2005; 67: 522-30.
  3. Kalkstein L., Smoyer K. The impact of climate change on human health: Some international implications // Experiencia. - 1993; 49: 469-79.
  4. Schulman M., Narins R. Hypokalemia and cardiovascular disease // Am. J. Cardiol. - 1990; 65: 4-9.
  5. Ueshima K. Magnesium and ischemic heart disease: a review of epidemiological, experimental, and clinical evidences // Magnes Res. - 2005; 18 (4): 275-84.
  6. Dahl L. Salt intake and salt need // N. Engl. J. Med. - 1958; 258: 1152-205.
  7. Постникова С.Л., Касатова Т.Б., Верещагина Г.С. и др. Магний и сердечно-сосудистые заболевания // РМЖ. - год; 15 (20): 1498-501.
  8. lezhitsa I. Potassium and magnesium depletions in congestive heart failure-pathophysiology, consequences and replenishment // Clin. Calcium. - 2005; 15 (11): 123-33.
  9. Белозерцев Ф.Ю., Юнцев С.В., Белозерцев Ю.А. и др. Сравнительная оценка нейропротекторного действия ноотропов, блокаторов кальциевых каналов и панангина // Экспер. и клин. фармакология. - 2007; 5: 12-4.
  10. Дубровский В.И. Реабилитация в спорте. - М.: Физкультура и спорт. - 1991; 25 с.
  11. Dumont L., Mardirosoff C., Tramer M. Efficacy and harm of pharmacological prevention of acute mountain sickness: quantitative systematic review // BMJ. - год; 321: 267-72.
  12. Young D., Lin, McCabe R. Potassium's cardiovascular protective mechanisms // Am. J. Physiol. - 1995; 268: 825-37.
  13. Чазова И.Е., Агеев Ф.Т., Смирнова М.Д. и др. Влияние аномальной жары лета 2010 года на состояние здоровья кардиологических больных и тактика практикующих врачей амбулаторно-поликлинического звена // Системные гипертензии. - 2011; 8 (4): 47-50.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies