IMMUNOPATHOLOGY AND BIOCHEMICAL VIEWPOINTS BEHIND THE TREATMENT OF ATOPIC CONDITIONS


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Abstract

Investigations of altered immunological reactivity provide a key for understanding the atopic disease. Multisite receptor interactions of first-generation antihistamines like clemastine offer rapid therapeutic efficacy in allergology and pediatry ward.

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About the authors

I. Grigoryeva

Institute of Allergology and Clinical Immunology

A. Sergeyev

I.M. Sechenov First Moscow State Medical University

I. Manina

Institute of Allergology and Clinical Immunology

E. Kudryavtseva

Medico-C Medical Rehabilitation Center

Email: iaci@iaci.ru
Moscow

References

  1. Сергеев Ю.В., Новиков Д.К., Караулов А.В. и др. Атопический дерматит: гетерогенность клинических форм и разнообразие механизмов патогенеза // Иммунопатология, аллергология, инфектология. - 2001; 3: 61-73.
  2. Noh G., Lee J. Revision of immunopathogenesis and laboratory interpretation for food allergy in atopic dermatitis // Inflamm. Allergy Drug. Targets. - 2012; 11 (1): 20-35.
  3. Proksch E., Weidinger S. New insights into the pathogenesis of sensitive skin // Hautarzt. - 2011; 62 (12): 900-905..
  4. Herman S., Vender R. Antihistamines in the treatment of dermatitis // Cutan Med Surg. - 2003; 7 (6): 467-473.
  5. Strid J., Sobolev O., Zafirova B. et al. The intraepithelial T cell response to NKG2D-ligands links lymphoid stress surveillance to atopy // Science. - 2011; 334 (6060): 1293-1297.
  6. Binder A., Koroschetz J., Baron R. Disease mechanisms in neuropathic itch // Nat. Clin. Pract. Neurol. - 2008; 4 (6): 329-337.
  7. Lee C., Yu H. Biomarkers for itch and disease severity in atopic dermatitis // Curr. Probl. Dermatol. - 2011; 41: 136-148.
  8. Sunyer J., Basagaña X., Gonzalez J. et al. Early life environment, neurodevelopment and the interrelation with atopy // Environ. Res. - 2010; 110 (7): 733-738.
  9. Ando T., Hashiro M., Noda K. et al. Development and validation of the psychosomatic scale for atopic dermatitis in adults // J. Dermatol. - 2006; 33 (7): 439-450.
  10. Meador K., Loring D., Ray P. et al. Role of cerebral lateralization in control of immune processes in humans // Ann. Neurol. - 2004; 55 (6): 840-844.
  11. Muñoz-Hoyos A., Espín-Quirantes C., Molina-Carballo A. et al. Neuroendocrine and circadian aspects (melatonin and beta-endorphin) of atopic dermatitis in the child // Pediatr. Allergy Immunol. - 2007; 18 (8): 679-686.
  12. Ikoma A., Fartasch M., Heyer G. et al. Painful stimuli evoke itch in patients with chronic pruritus: central sensitization for itch // Neurology. - 2004; 62 (2): 212-217.
  13. Sinkus M., Wamboldt M., Barton A. The α7 nicotinic acetylcholine receptor and the acute stress response: maternal genotype determines offspring phenotype // Physiol. Behav. - 2011; 104 (2): 321-326.
  14. Peters J., Cohen S., Staudenmayer J. et al. Prenatal negative life events increases cord blood IgE: interactions with dust mite allergen and maternal atopy: Epidemiology and Genetics // Allergy. - 2012; 6. doi: 10.1111/ j.1398-9995.2012.02791.x.
  15. Lazewska D., Kiec-Kononowicz K. Azines as histamine H4 receptor antagonists // Front Biosci (Schol Ed). - 2012; 4: 967-987.
  16. Iking A., Grundmann S., Chatzigeorgakidis E. et al. Prurigo as a symptom of atopic and non-atopic diseases: aetiological survey in a consecutive cohort of 108 patients // J. Eur. Acad. Dermatol. Venereol. - 20125.oi: 10.1111/ j.1468-3083.2012.04481.x.
  17. Geng S., Gao Y., Yang J. et al. Potential role of store-operated Ca(2+) entry in Th(2) response induced by histamine in human monocyte-derived dendritic cells // Int. Immunopharmacol. - 2012; 12 (2): 358-367.
  18. del Rio R., Noubade R., Saligrama N. et al. Histamine H4 receptor optimizes T regulatory cell frequency and facilitates anti-inflammatory responses within the central nervous system // J. Immunol. - 2012; 188 (2): 541-547.
  19. Liezmann C., Klapp B., Peters E. Stress, atopy and allergy: A re-evaluation from a psychoneuroimmunologic persepective // Dermatoendocrinol. - 2011; 3 (1): 37-40.
  20. Steinman L. Elaborate interactions between the immune and nervous systems // Nat. Immunol. - 2004; 5 (6): 575-581.
  21. Johansen P., Weiss A., Bünter A. et al. Clemastine causes immune suppression through inhibition of extracellular signal-regulated kinase-dependent proinflammatory cytokines // J. Allergy Clin. Immunol. - 2011; 128 (6): 1286-1294.
  22. Doherty V., Sylvester D., Kennedy C. et al. Treatment of itching in atopic eczema with antihistamines with a low sedative profile // BMJ. - 1987 (298): 96.
  23. Ito C. Histamine H3-receptor inverse agonists as novel antipsychotics // Cent Nerv Syst Agents Med Chem. - 2009; 9 (2): 132-136.
  24. Connelly W., Shenton F., Lethbridge N. et al. The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS // Br. J. Pharmacol. - 2009 May; 157 (1): 55-63.
  25. Johansen P., Weiss A., Bünter A. et al. Clemastine causes immune suppression through inhibition of extracellular signal-regulated kinase-dependent proinflammatory cytokines. // J Allergy Clin Immunol. - 2011; 128 (6): 1286-1294.
  26. Lojek A., Cíž M., Pekarová M.et al. Modulation of metabolic activity of phagocytes by antihistamines // Interdiscip Toxicol. - 2011; 4 (1): 15-19.
  27. Lindsberg P., Strbian D., Karjalainen-Lindsberg M. et al. Mast cells as early responders in the regulation of acute blood-brain barrier changes after cerebral ischemia and hemorrhage // J. Cereb. Blood. Flow. Metab. - 2010; 30 (4): 689-702.
  28. Chung J., deTineo M., Naclerio R. et al. Low dose clemastine inhibits sneezing and rhinorrhea during the early nasal allergic reaction // Annals of allergy, asthma & immunology. - 1997 (78): 307-312.
  29. Dorckhorn R., Bergner A., Connell J. et al. Safety and efficacy of loratadine (Sch-29851): a new non-sedating antihistamine in seasonal allergic rhinitis // Ann. Allergy. - 1987; 58: 407-411.
  30. Frolund L., Etholm B., Irlander K. et al. A multicentre study of loratadine, clemastine and placebo in patients with perennial allergic rhinitis // Allergy. - 1990; 45: 254-261.
  31. Лусс Л.В. Выбор антигистаминных препаратов в лечении аллергических и псевдоаллергических реакций // Рос. аллергологический журнал. - 2009; 1: 1-7.
  32. Полосьянц О.Б. Обзор антигистаминных средств первого и второго поколений, рациональный подход к использованию в клинической практике // Лечащий врач. - 2001; 7.

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