RISK FACTORS OF HEPATOCELLULAR CARCINOMA IN LIVER CIRRHOSIS IN THE OUTCOME OF AUTOIMMUNE HEPATITIS
- Authors: Lopatkina T.1, Nyaikina N.1, Tanashchuk E.1
-
Affiliations:
- I.M. Sechenov First Moscow State Medical University
- Issue: Vol 24, No 11 (2013)
- Pages: 2-4
- Section: Articles
- URL: https://journals.eco-vector.com/0236-3054/article/view/115739
- ID: 115739
Cite item
Open Access
Access granted
Abstract
Addition of hepatitis C virus (HCV) infection to liver cirrhosis in the outcome of autoimmune hepatitis (AIH) was a cause of hepatocellular carcinoma and death in a young female woman (aged 35 years). The probability of primary liver cancer should be excluded in patients with AIH with its impaired stability and the signs of high disease activity. The possibility of seronegative HCV infection determines the need to use a highly sensitive polymerase chain reaction for the detection of the infection in serum and liver tissue.
Full Text
About the authors
T. Lopatkina
I.M. Sechenov First Moscow State Medical University
Email: lopatkina-tn@mail.ru
Candidate of Medical Sciences
N. Nyaikina
I.M. Sechenov First Moscow State Medical University
E. Tanashchuk
I.M. Sechenov First Moscow State Medical UniversityCandidate of Medical Sciences
References
- Бурневич Э., Лопаткина Т., Никулкина Е. Современные представления о гепатоцеллюлярной карциноме // Врач. - 2011; 12: 17-20.
- Park S., Nagorney D., Czaja A. Hepatocellular carcinoma in autoimmune hepatitis // Dig. Dis. Sci. - 2000; 45 (10): 1944-8.
- Chui A., Rao A., McCaughan G. et al. An active liver transplantant programme for hepatocellular carcinoma in cirrhotic patients: is it justified? // Clin. Transplant. - 1999; 13 (6): 531-5.
- Лопаткина Т.Н. Аутоиммунный гепатит и перекрестные синдромы // Фарматека. - 2010; 15: 62-8.
- Тихонова Н.Ю., Лопаткина Т.Н., Одинцов А.В. Аутоиммунный гепатит как редкое нежелательное явление противовирусной терапии хронического гепатита С // Врач. - 2013; 8: 30-3.
- Ryder S., Koskinas J., Rizzi P. et al. Hepatocellular Carcinoma Complicating Autoimmune Hepatitis: Role of Hepatitis C Virus // Hepatology. - 1995; 22 (3): 718-22.
- Лопаткина Т., Фатхудинов Т. Гепатоцеллюлярная карцинома // Врач. -2002; 10: 20-3.
- Sheu J., Sung J., Chen D. et al. Growth rate of asymptomatic hepatocellular carcinoma and its clinical implications // Gastroenterology. - 1985; 89: 259-66
- Poterucha J., Rakela J., Lumeng L. et al. Diagnosis of chronic hepatitis C after liver transplantation by the detection of viral sequences with polymerase chain reaction // Hepatology. - 1992; 15: 42-5.
- Лопаткина Т.Н., Абдурахманов Д.Т., Крель П.Е. и др. Гепатоцеллюлярная карцинома и вирусы гепатита // Гепатол. форум. - 2005; 1: 20-2.
- Imai H., Nakano Y., Kiyosawa K. et al. Increasing titers and changing specificities of antinuclear antibodies in patients with chronic liver disease who develop hepatocellular carcinoma // Cancer. - 1993; 71 (1): 26-35.
- Jemal A., Siegel R., Ward E. et al. Cancer statistics // CA Cancer J. Clin. -2009; 59: 225-49.
- Llovet J. Гепатоцеллюлярный рак: повышенный уровень альфа-фетопротеина без объемного образования при ультразвуковом исследовании // Клин. гастроэнтерол. гепатол. (rus.). - 2009; 3: 225-31.
Supplementary files
