GLUCOSOTOXICITY AND LIPOTOXICITY ARE MUTUALLY AGGRAVATING FACTORS IN CONCOMITANCE OF TYPE 2 DIABETES MELLITUS AND OBESITY
- Authors: Ametov A.1, Kamynina L.1, Akhmedova I.2
-
Affiliations:
- Russian Academy of Postgraduate Education
- Azerbaijan State Institute for Postgraduate Training of Physicians
- Issue: Vol 25, No 4 (2014)
- Pages: 20-23
- Section: Articles
- URL: https://journals.eco-vector.com/0236-3054/article/view/115890
- ID: 115890
Cite item
Open Access
Access granted
Abstract
The paper considers the negative sequels of glucosotoxicity, lipotoxicity, and glucolipotoxicity in patients with type 2 diabetes mellitus in the presence of visceral obesity and outlines the ways of correcting these metabolic disturbances.
Full Text
About the authors
A. Ametov
Russian Academy of Postgraduate Education
Email: petrology@yandex.ru
Professor
L. Kamynina
Russian Academy of Postgraduate Education
Email: petrology@yandex.ru
Candidate of Medical Sciences
I. Akhmedova
Azerbaijan State Institute for Postgraduate Training of PhysiciansCandidate of Medical Sciences
References
- Kim J., Yoon K. Glucolipotoxicity in Pancreatic β-Cells // Diabetes Metab. J. - 2011; 35 (5): 444-50.
- Nielsen R., Nerrelund H., Kampmann U. et al. Failing heart of patients with type 2 diabetes mellitus can adapt to extreme short-term increases in circulating lipids and does not display features of acute myocardial lipotoxicity // Circ. Heart Fail. - 2013; 6 (4): 845-52.
- Prentki M., Joly E., El-Assaad W. et al. Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes // Diabetes. - 2002; 51 (3): 405-13.
- Shao S., Yang Y., Yuan G. et al. Signaling molecules involved in lipid-induced pancreatic beta-cell dysfunction // DNA Cell. Biol. - 2013; 32 (2): 41-9.
- Erdogdu O., Eriksson L., Xu H. et al. Exendin-4 protects endothelial cells from lipoapoptosis by PKA, PI3K, eNOS, p38 MAPK, and JNK pathways // J. Mol. Endocrinol. - 2013; 50 (2): 229-41.
- Maris M., Ferreira G., D'Hertog W. et al. High glucose induces dysfunction in insulin secretory cells by different pathways: a proteomic approach // J. Proteome Res. - 2010; 9 (12): 6274-87.
- Karunakaran U., Kim H., Kim J. et al. Guards and culprits in the endoplasmic reticulum: glucolipotoxicity and β-cell failure in type II diabetes // Exp. Diabetes Res. - 2012; 2012: 639762.
- Kim M., Kim H., Lee I. et al. Endoplasmic reticulum stress and insulin biosynthesis: a review // Exp. Diabetes Res. - 2012; 2012: 509437.
- Rockenfeller P., Ring J., Muschett V. et al. Fatty acids trigger mitochondrion-dependent necrosis // Cell. Cycle. - 2010; 9 (14): 2836-42.
- Madsbad S. The role of glucagon-like peptide-1 impairment in obesity and potential therapeutic implications // Diabetes Obes. Metab. - 2013; 15: 11. doi: 10.1111/dom.12119
- Taegtmeyer H., Stanley W. Too much or not enough of a good thing? Cardiac glucolipotoxicity versus lipoprotection // J. Mol. Cell. Cardiol. - 2011; 50 (1): 2-5.
Supplementary files
