MYOCARDIAL PRECONDITIONING WITH TRIMETAZIDINE DURING CORONARY BYPASS SURGERY UNDER EXTRACORPOREAL CIRCULATION
- Authors: Plchugln V.1, Antsygina L.2, Kordatov P.2, Maksimov A.2
-
Affiliations:
- Nizhny Novgorod State Medical Academy
- Specialized Cardiac Surgery Clinical Hospital
- Issue: Vol 25, No 4 (2014)
- Pages: 27-32
- Section: Articles
- URL: https://journals.eco-vector.com/0236-3054/article/view/115900
- ID: 115900
Cite item
Open Access
Access granted
Abstract
Trimetazidine used in patients with coronary heart disease during coronary bypass surgery under extracorporeal circulation and pharmacological cold cardioplegia provides an additional cardioprotective effect.
Full Text
About the authors
V. Plchugln
Nizhny Novgorod State Medical Academy
Email: pichugin.vldmr@rambler.ru
Professor
L. Antsygina
Specialized Cardiac Surgery Clinical HospitalCandidate of Medical Sciences Nizhny Novgorod
P. Kordatov
Specialized Cardiac Surgery Clinical HospitalCandidate of Medical Sciences Nizhny Novgorod
A. Maksimov
Specialized Cardiac Surgery Clinical HospitalCandidate of Medical Sciences Nizhny Novgorod
References
- Бокерия Л.A., Чичерин И.Н. Природа и клиническое значение «новых ишемических синдромов» / М.: НЦССХ им. А.Н. Бакулева РАМН, 2007; 302 с.
- Weman S., Karhunen P., Penttila A. et al. Reperfusion injury associated with one-fourth of deaths after coronary artery bypass grafting // Ann. Thorac. Surg. -2000; 70: 807-12.
- Jenkins D., Pugsley W., Alkhulaifi A. et al. Ischaemic preconditioning reduces troponin T release in patients undergoing coronary artery bypass surgery // Heart. - 1997; 77: 314-8.
- Lagadic-Gossmann D., Le Prigent K., Feuvray D. Effects of trimetazidine on pH regulation in the rat isolated ventricular myocyte // Br. J. Pharmacol. - 1996; 117 (5): 831-8.
- Guarnieri C., Finelli C., Zini M. et al. Effects of trimetazidine on the calcium transport and oxidative phosphorylation of isolated rat heart mitochondria // Basic Res. Cardiol. - 1997; 92 (2): 90-5.
- Maupoil V., Rochette L., Tabard A. et al. Direct measurement of free radical generation in isolated rat heart by electron paramagnetic resonance spectroscopy: effect of trimetazidine // Adv. Exp. Med. Biol. - 1990; 264: 373-6.
- Drake-Holland A., Belcher P., Hynd J. et al. Infarct size in rabbits: a modified method illustrated by effects of propranolol and trimetazidine // Basic Res. Cardiol. - 1993; 88 (3): 250-8.
- Williams F., Tanda K., Kus M. et al. Trimetazidine inhibits neutrophil accumulation after myocardial ischaemia and reperfusion in rabbits // J. Cardiovasc. Pharmacol. - 1993; 22 (6): 828-33.
- Kober G., Pennaforte S., Buck T. et al. Myocardial cytoprotection during percutaneous transluminal coronary angioplasty // Eur. Heart J. - 1993; 14 (Suppl G): 6-11.
- Birand A., Kudaiberdieva G., Batyraliev T. et al. Effects of trimetazidine on heart rate variability and left ventricular systolic performance in patients with coronary artery disease after percutaneous transluminal angioplasty // Angiology. -1997; 48 (5): 413-22.
- Steg P., Grollier G., Gallay P. et al. A randomized double-blind trial of intravenous trimetazidine as adjunctive therapy to primary angioplasty for acute myocardial infarction // Int. J. Cardiol. - 2001; 77 (2-3): 263-73.
- Potóski L., Dec I., Wojnar R. et al. Trimetazidine limits the effects of myocardial ischaemia during percutaneous coronary angioplasty // Curr. Med. Res. Opin. - 2002; 18 (7): 389-96.
- Labrou A., Giannoglou G., Zioutas D. et al. Trimetazidine administration minimizes myocardial damage and improves left ventricular function after percutaneous coronary intervention // Am. J. Cardiovasc. Drugs. - 2007; 7 (2): 143-50.
- Bonello L., Sbragia P., Amabile N. et al. Protective effect of an acute oral loading dose of trimetazidine on myocardial injury following percutaneous coronary intervention // Heart. - 2007; 93 (6): 703-7.
- Tunerir B., Colak O., Alatas O. et al. Measurement of troponin T to detect cardioprotective effect of trimetazidine during coronary artery bypass grafting // Ann. Thorac. Surg. - 1999; 68 (6): 2173-6.
- Vedrinne J., Vedrinne C., Bompard D. et al. Myocardial protection during coronary artery bypass graft surgery: a randomized, double-blind, placebocontrolled study with trimetazidine // Anesth. Analg. - 1996; 82 (4): 712-8.
- Fabiani J., Ponzio O., Emerit I. et al. Cardioprotective effect of trimetazidine during coronary artery graft surgery // J. Cardiovasc. Surg. (Torino). - 1992; 33 (4): 486-91.
- Лопатин Ю.М., Дронова Е.Н. Клинико-фармакоэкономические аспекты применения триметазидина модифицированного высвобождения у больных ИБС, подвергнутых коронарному шунтированию // Кардиология. - 2009; 49 (2): 1-7.
Supplementary files
