LATENT HBV INFECTION IN PATIENTS WITH CHRONIC HEPATITIS B


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Abstract

Latent HBV infection characterized by the isolated location of viral DNA in the liver in the absence of HBEe-, HBs-antigenemia and viremia was identified in 40,8% of patients with chronic viral hepatitis B (CVHB) in the presence of IgG class antibodies to nuclear HBV protein. CVHB with latent infection showed a weak activity and low-symptom benign course in 69,4% of the patients; but in 12,2% hepatocytic inflammation and fibrosis continuously progressed and liver cirrhosis developed 15-20 years later.

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About the authors

O. Dudanova

Petrozavodsk State University

Email: odudanova@gmail.com

M. Shubina

Petrozavodsk State University

Candidate of Medical Sciences

A. Larina

Petrozavodsk State University

M. Pisareva

Research Institute of Influenza

Candidate of Biological Sciences

M. Grudinin

Research Institute of Influenza

Candidate of Biological Sciences

O. Kiselev

Research Institute of Influenza

Biol.D, Academician of the Russian Academy of Medical Sciences

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