BIOCHEMICAL PARAMETERS OF LIPID METABOLISM IN PATIENTS WITH UNSTABLE ANGINA AND HEMODYNAMICALLY SIGNIFICANT CORONARY STENOSIS


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Abstract

Seventy-five male and female patients aged 60.1±10.7 years with coronary heart disease (CHD) and unstable angina were examined. A group of patients with hemodynamically significant coronary stenosis (HSCS) was identified by selective coronary angiography. Higher levels of atherogenic lipid fractions were found in the patients with unstable angina and HSCS than in those without HSCS, with the equivalent activation of markers for a systemic inflammatory response and with endothelial dysfunction as plasma endothelin 1 hyperproduction being in the patients of both groups. There were multiple direct correlations between the levels of atherogenic lipid fractions, inflammatory markers, and the degree of coronary artery atherosclerotic stenosis.

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About the authors

T. Petelina

Branch, Research Institute of Cardiology, Siberian Branch, Russian Academy of Medical Sciences, Tyumen Cardiology Center

Email: petelina@cardio.tmn.ru
MD

N. Musikhina

Branch, Research Institute of Cardiology, Siberian Branch, Russian Academy of Medical Sciences, Tyumen Cardiology Center

Candidate of Medical Sciences

L. Gapon

Branch, Research Institute of Cardiology, Siberian Branch, Russian Academy of Medical Sciences, Tyumen Cardiology Center

Professor, MD

A. Takkand

Branch, Research Institute of Cardiology, Siberian Branch, Russian Academy of Medical Sciences, Tyumen Cardiology Center

I. Osipova

Branch, Research Institute of Cardiology, Siberian Branch, Russian Academy of Medical Sciences, Tyumen Cardiology Center

O. Belosludtseva

Branch, Research Institute of Cardiology, Siberian Branch, Russian Academy of Medical Sciences, Tyumen Cardiology Center

References

  1. Шальнова С.А. Эпидемиология сердечно-сосудистых заболеваний и факторы риска в России. Кардиология. Нац. рук-во / М.: ГЭОТАР-Медиа, 2007; с. 37-52.
  2. Братусь В.В., Талаева Т.В. Воспаление как патогенетическая основа атеросклероза / Киев: Национальный научный центр «Институт кардиологии им. Н.Д. Стражеско» АМН Украины, 2007.
  3. Орлова Н.В., Чукаева, И.И., Солошенкова О.О. и др. Изучение взаимосвязи уровней острофазных белков и нарушений липидного обмена у больных ИБС с поражением коронарных артерий // Кардиоваск. терапия и профилакт. - 2008; 7 (6), прил. 1; с. 271.
  4. Тепляков А.Т., Рыбальченко Е.В., Аптекарь В.Д. и др. Рецидивы стенокардии после стентирования коронарных артерий: влияние дислипидемии // Бюллетень СО РАМН. - 2006; 1 (119): 13-7.
  5. Erbel R., Ge J., Bockisch A. et al. Value of intracoronary ultrasound and Doppler in the differentiation of angiographically normal coronary arteries: a prospective study in patients with angina pectoris // Eur. Heart J. - 1996; 17: 880-9.
  6. Eckardstein A., Schulte H., Cullen P. et al. Lipoprotein (a) Further Increases the Risk of Coronary Events in Men With High Global Cardiovascular Risk // J. Am. Coll. Cardiol. - 2001; 37 (2): 434-9.
  7. Зыков К.А., Нуралиев Э.Ю., Казначеева Е.И. и др. Динамика воспалительного процесса у больных с острым коронарным синдромом и стабильной стенокардией // Кардиол. вестн. - 2011; 1: 23-33.
  8. Memon L., Spasojevic-Kalimanovska V. et al. Association of C-reactive protein with the Presense and Extent of Angiographically Verified Coronary Artery Disease // Exp. Med. - 2006; 209: 197-206.
  9. Гусев Д.Е., Потиевский Б.Г., Райчевин Н. и др. Маркеры воспаления при различных формах ишемической болезни сердца. // Кардиология. - 2012; 4: 4-8.
  10. Hisashi Kai, Hisao Ikeda, Hideo Yasukawa et al. Peripheral blood levels of matrix metalloproteinases-2 and -9 are elevated in patients with acute coronary syndromes // JACC. - 1998; 32 (2): 368-72
  11. Hartmann M., von Birgelen C., Mintz G. et al. Relation between lipoprotein (a) and fibrinogen and serial intravascular ultrasound plaque progression in left main coronary arteries // J. Am. Coll. Cardiol. - 2006; 48 (3): 446-52.
  12. Шевченко О.П. Новые лабораторные маркеры ангиогенеза и повреждения атеросклеротической бляшки // Клин. лаб. диагностика. - 2006; 6: 23-34.
  13. Шевченко О.П., Природова О.Ф., Орлова О.В. и др. CD 40 лиганд у больных ишемической болезнью сердца в сочетании с сахарным диабетом 2 типа // Кардиоваск. терапия и профилак. - 2006; 5 (7): 101-11.
  14. Vogel R. Coronary risk factors, endothelial function, and atherosclerosis: a review // Clin. Cardiol. - 1997; 20 (5): 426-32.

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