Zonulin as a marker of intestinal permeability in patients with acne associated with celiac disease
- Authors: Ledentsova S.S.1, Gulyaev N.I.2, Klyuchereva S.V.3, Oreshko L.S.3, Seliverstov P.V.4
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Affiliations:
- Consultative and Diagnostic Center, Saint Petersburg State Pediatric Medical University Ministry of Health of Russia
- A.A. Vishnevsky Central Military Clinical Hospital. Ministry of Defense of Russia
- I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia
- S.M. Kirov Military Medical Academy, Ministry of Defense of Russia
- Issue: Vol 34, No 1 (2023)
- Pages: 59-63
- Section: From Practice
- URL: https://journals.eco-vector.com/0236-3054/article/view/397445
- DOI: https://doi.org/10.29296/25877305-2023-01-13
- ID: 397445
Cite item
Abstract
The intestinal barrier plays an important role in maintaining gut and whole body immune homeostasis. The role of the gastrointestinal microbiota is significant in maintaining intestinal tightness as the latter affects the intestinal barrier. Shifting the balance of the gut microbiota composition towards opportunistic microorganisms is known to lead to increased secretion of the recently discovered protein zonulin. The level of zonulin in patients with various diseases makes it possible to judge the change in intestinal wall permeability during pathological processes or different types of therapy. The present study examined for the first time the effect of a gluten-free diet on the course of acne in patients with and without celiac disease. The given study was the first to investigate the effect of a gluten-free diet on the course of acne in patients with and without celiac disease.
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About the authors
S. S. Ledentsova
Consultative and Diagnostic Center, Saint Petersburg State Pediatric Medical University Ministry of Health of Russia
Email: seliverstov-pv@yandex.ru
ORCID iD: 0000-0001-9897-5989
Russian Federation, Saint Petersburg
N. I. Gulyaev
A.A. Vishnevsky Central Military Clinical Hospital. Ministry of Defense of Russia
Email: seliverstov-pv@yandex.ru
ORCID iD: 0000-0002-7578-8715
Doctor of Medical Sciences
Russian Federation, KrasnogorskS. V. Klyuchereva
I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia
Email: seliverstov-pv@yandex.ru
Doctor of Medical Sciences, Professor
Russian Federation, Saint PetersburgL. S. Oreshko
I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia
Email: seliverstov-pv@yandex.ru
ORCID iD: 0000-0002-2726-9996
Doctor of Medical Sciences, Professor
Russian Federation, Saint PetersburgP. V. Seliverstov
S.M. Kirov Military Medical Academy, Ministry of Defense of Russia
Author for correspondence.
Email: seliverstov-pv@yandex.ru
ORCID iD: 0000-0001-5623-4226
Candidate of Medical Sciences, Associate Professor
Russian Federation, Saint PetersburgReferences
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