The role of immunomodulatory therapy in the treatment of acute respiratory viral infections in patients with year-round allergic rhinitis
- Authors: Trukhan D.I.1, Bagisheva N.V.1, Nesterova K.I.1, Mordyk A.V.1, Alekseenko V.A.2, Moiseeva M.V.2, Kalashnikova N.M.2, Neshcheretneva V.N.2
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Affiliations:
- Omsk State Medical University
- Omsk City Polyclinic No. 12
- Issue: Vol 34, No 8 (2023)
- Pages: 39-43
- Section: Pharmacology
- URL: https://journals.eco-vector.com/0236-3054/article/view/569055
- DOI: https://doi.org/10.29296/25877305-2023-08-07
- ID: 569055
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Abstract
Objective. To assess the effectiveness and safety of the combined medicine interferon alpha-2b + loratadine (Grippferon® with loratadine, nasal ointment) for the prevention and treatment of acute respiratory viral infections (ARVI) in patients with year-round allergic rhinitis.
Materials and Methods. A total of 154 patients were included in the study and divided into four groups: group 1A patients (n=37) received the combined medicine interferon alpha-2b + loratadine (Grippferon® with loratadine) 5 times a day for 7 days for the ARVI treatment; in group 2A (n=41) standard therapy was carried out in accordance with the clinical guidelines for the ARVI treatment in adult patients (2021). Group 1B (n=38) patients used the combined medicine interferon alpha-2b + loratadine once a day for 7 days for the ARVI prevention; in group 2B patients (n=38) ARVI prevention was not conducted. There were 75 (48.7%) men and 79 (51.3%) women, aged 22-45 years.
Results. During treatment with the combined medicine interferon alpha-2b + loratadine in group 1A patients there was a significant decrease in respiratory manifestations (such as nasal congestion, rhinorrhoea, sneezing) by comparing with group 2A patients. Rhinocytogram analysis results showed that the use of the combined medicine interferon alpha-2b + loratadine contributed to the reduction in the intensity and severity of inflammatory (leukocyte count) and allergic (eosinophils) responses. In group 1B patients, who received the medicine interferon alpha-2b + loratadine for the ARVI prevention, we noted that during three observation months 3 times less patients got acute respiratory infections by comparing with group 2B patients.
Conclusion. The received study results demonstrate that the use of topical medicine interferon alpha-2b + loratadine in patients with concomitant acute respiratory viral infections and year-round allergic rhinitis shortens the ARVI treatment period. The preventive use of the given medicine allows us to reduce the number of ARVI in patients with year-round allergic rhinitis.
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About the authors
D. I. Trukhan
Omsk State Medical University
Author for correspondence.
Email: ppi100@mail.ru
ORCID iD: 0000-0002-1597-1876
Dr Med. Sci
Russian Federation, OmskN. V. Bagisheva
Omsk State Medical University
Email: ppi100@mail.ru
ORCID iD: 0000-0003-3668-1023
Cand. of Med. Sci.
Russian Federation, OmskK. I. Nesterova
Omsk State Medical University
Email: ppi100@mail.ru
ORCID iD: 0000-0002-9793-7179
Dr Med. Sci
Russian Federation, OmskA. V. Mordyk
Omsk State Medical University
Email: ppi100@mail.ru
ORCID iD: 0000-0001-6196-7256
Dr Med. Sci., Professor
Russian Federation, OmskV. A. Alekseenko
Omsk City Polyclinic No. 12
Email: ppi100@mail.ru
Russian Federation, Omsk
M. V. Moiseeva
Omsk City Polyclinic No. 12
Email: ppi100@mail.ru
ORCID iD: 0000-0003-3458-9346
Cand. of Med. Sci
Russian Federation, OmskN. M. Kalashnikova
Omsk City Polyclinic No. 12
Email: ppi100@mail.ru
Russian Federation, Omsk
V. N. Neshcheretneva
Omsk City Polyclinic No. 12
Email: ppi100@mail.ru
Russian Federation, Omsk
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