Kidney damage in patients with inflammatory bowel diseases: a clinical case

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Abstract

Kidney damage in patients with inflammatory bowel diseases often presents difficulties for early diagnosis and management of such patients, which is largely due to the absence of pronounced clinical manifestations, at the same time there is a fairly short time interval for reversibility of renal damage, which requires a certain alertness of practitioners. This article presents a clinical case of a 32-year-old patient with a long history of systemic inflammatory disease who consulted a nephrologist due to increasing azotemia.

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V. V. Poliakova

I.I. Mechnikov North-West State Medical University, Ministry of Health of Russia

Author for correspondence.
Email: poljakovavalentina@list.ru

Doctor of Medical Sciences, Associate Professor

Russian Federation, Saint Petersburg

N. Kunitskaya

I.I. Mechnikov North-West State Medical University, Ministry of Health of Russia

Email: poljakovavalentina@list.ru

Doctor of Medical Sciences, Professor

Russian Federation, Saint Petersburg

A. Chistyakova

I.I. Mechnikov North-West State Medical University, Ministry of Health of Russia

Email: poljakovavalentina@list.ru
Russian Federation, Saint Petersburg

N. Bakulina

I.I. Mechnikov North-West State Medical University, Ministry of Health of Russia

Email: poljakovavalentina@list.ru
Russian Federation, Saint Petersburg

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2. Fig. 1. Light microscopy: focal granulomatous non-immunocomplex vasculitis with involvement of the artery – disruption of the arterial wall layers with marked intramural and perivascular "palisade-like" infiltration, represented by plasma cells, histiocytes, lymphocytes and numerous eosinophilic leukocytes; with formation of non-necrotizing histiocytic granuloma. Hematoxylin & Eosin stain; ×200

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3. Fig. 2. Chronic segmental granulomatous erosive colitis with morphological features of Crohn's disease: a – focal moderate inflammatory component, focal high activity, marked eosinophilic component, deep spread of inflammatory infiltration (hematoxylin/eosin stain; ×100); б – epithelioid non-necrotizing granuloma with giant multinucleated cells (hematoxylin/eosin stain; ×200)

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