Ultrasound assessment of peripheral nerves in patients with type 1 diabetes mellitus of varying duration in childhood and adolescence

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The annual increase in the number of patients with diabetes mellitus (DM) requires additional attention to the issue of improving the quality of life of patients and reducing the risks of developing complications in the long term.

Purpose. To study changes in ultrasound parameters of peripheral nerves in patients with type 1 diabetes mellitus (T1DM) of varying duration in childhood and adolescence.

Material and methods. The study included data from 190 children aged 5–18 years, including 139 children with an established diagnosis of T1DM of varying duration and 51 children from the control group. All patients underwent ultrasound of the peripheral nerves of the lower extremities using B-mode, color Doppler mapping, preppler microvascularization, and shear wave elastography mode.

Results. The data obtained indicate the promise of using ultrasound for diagnosis and dynamic monitoring of the condition of peripheral nerves in patients with T1DM in childhood and adolescence. The combination of increased stiffness and increased size of peripheral nerves of the lower extremities is a sign of nerve changes in T1DM in childhood and adolescence.

Full Text

Restricted Access

About the authors

S. V. Fomina

Siberian State Medical University, Ministry of Health of Russia

Author for correspondence.
Email: statfom@mail.ru
ORCID iD: 0000-0001-7517-3393

Candidate of Medical Sciences, Associate Professor

Russian Federation, Tomsk

V. D. Zavadovskaya

Siberian State Medical University, Ministry of Health of Russia

Email: statfom@mail.ru
ORCID iD: 0000-0001-6231-7650

MD, Professor

Russian Federation, Tomsk

Yu. G. Samoilova

Siberian State Medical University, Ministry of Health of Russia

Email: statfom@mail.ru
ORCID iD: 0000-0002-2667-4842

MD, Professor

Russian Federation, Tomsk

D. A. Kudlay

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia; M.V. Lomonosov Moscow State University

Email: statfom@mail.ru
ORCID iD: 0000-0003-1878-4467

Corresponding Member of the Russian Academy of Sciences, MD, Professor

Russian Federation, Moscow; Moscow

M. V. Koshmeleva

Siberian State Medical University, Ministry of Health of Russia

Email: statfom@mail.ru
ORCID iD: 0000-0001-8142-1226

Candidate of Medical Sciences

Russian Federation, Tomsk

D. A. Kachanov

Siberian State Medical University, Ministry of Health of Russia

Email: statfom@mail.ru
ORCID iD: 0000-0002-6519-8906
Russian Federation, Tomsk

E. I. Trifonova

Siberian State Medical University, Ministry of Health of Russia

Email: statfom@mail.ru
ORCID iD: 0000-0002-2825-5035
Russian Federation, Tomsk

M. A. Zorkaltsev

Siberian State Medical University, Ministry of Health of Russia

Email: statfom@mail.ru
ORCID iD: 0000-0003-0025-2147

MD

Russian Federation, Tomsk

V. E. Yun

Siberian State Medical University, Ministry of Health of Russia

Email: statfom@mail.ru
ORCID iD: 0000-0002-9127-8619
Russian Federation, Tomsk

References

  1. Дедов И.И., Шестакова М.В., Викулова О.К. и др. Эпидемиологические характеристики сахарного диабета в Российской Федерации: клинико-статистический анализ по данным регистра сахарного диабета на 01.01.2021. Сахарный диабет. 2021; 24 (3): 204–21 [Dedov I.I., Shestakova M.V., Vikulova O.K., et al. Epidemiological characteristics of diabetes mellitus in the Russian Federation: clinical and statistical analysis according to the Federal diabetes register data of 01.01.2021. Diabetes mellitus. 2021; 24 (3): 204–21 (in Russ.)]. doi: 10.14341/DM12759
  2. Самойлова Ю.Г., Ротканк М.А., Жукова Н.Г. и др. Вариабельность гликемии у пациентов с сахарным диабетом 1-го типа: связь с когнитивной дисфункцией и данными магнитно-резонансных методов исследования. Проблемы Эндокринологии. 2018; 64 (5): 286–91 [Samoilova I.G., Rotkank M.A., Zhukova N.G. et al. Variability of glycemia in patients with type 1 diabetes mellitus: the relationship with cognitive dysfunction and the results of magnetic resonance imaging. Problems of Endocrinology. 2018; 64 (5): 286–91 (in Russ.)]. doi: 10.14341/probl9589
  3. Никитин С.С., Муртазина А.Ф., Дружинин Д.С. Блок проведения возбуждения по периферическому нерву как электрофизиологический феномен: обзор литературы. Нервно-мышечные болезни. 2019; 9 (1): 12–23 [Nikitin S.S., Murtazina A.F., Druzhinin D.S. Conduction block of excitation along the peripheral nerve as an electrophysiological phenomenon: a review of the literature. Neuromuscular Diseases. 2019; 9 (1): 12–23 (in Russ.)]. doi: 10.17650/2222-8721-2019-9-1-12-23
  4. Эластография сдвиговых волн. Анализ клинических примеров (практическое руководство для последипломной профессиональной переподготовки врачей). Учебное пособие. 2-е изд., перераб. и доп. Под ред. А.В. Борсукова. СИМК, 2022; 468 с. [Shear wave elastography. Analysis of clinical examples (a practical guide for postgraduate professional retraining of doctors). Textbook. 2nd ed., revised. and additional. Ed. by A.V. Borsukov. SIMK, 2022; 468 p. (in Russ.)].
  5. Borire A.A., Issar T., Kwai N.C. et al. Correlation between markers of peripheral nerve function and structure in type 1 diabetes. Diabetes Metab Res Rev. 2018; 34 (7): e3028. doi: 10.1002/dmrr.3028
  6. Goyal K., Aggarwal P., Gupta M. Ultrasound evaluation of peripheral nerves of the lower limb in diabetic peripheral neuropathy. Eur J Radiol. 2021; 145: 110058. doi: 10.1016/j.ejrad.2021.110058
  7. Narayan S., Goel A., Singh A.K. et al. High resolution ultrasonography of peripheral nerves in diabetic patients to evaluate nerve cross sectional area with clinical profile. Br J Radiol. 2021; 94 (1121): 20200173. doi: 10.1259/bjr.20200173
  8. Ranjan T., Chandak S., Malhotra A. et al. Role of High-resolution Ultrasonography in the Evaluation of the Tibial and Median Nerves in Diabetic Peripheral Neuropathy. J Ultrason. 2022; 22 (91): e209-e215. doi: 10.15557/jou.2022.0035
  9. Senarai T., Pratipanawatr T., Yurasakpong L. et al. Cross-Sectional Area of the Tibial Nerve in Diabetic Peripheral Neuropathy Patients: A Systematic Review and Meta-Analysis of Ultrasonography Studies. Medicina (Kaunas). 2022; 58 (12): 1696. doi: 10.3390/medicina58121696
  10. Singh Y., Dixit R., Singh S. et al. High resolution ultrasonography of peripheral nerves in diabetic peripheral neuropathy. Neurol India. 2019; 67 (Suppl): S71–S76. doi: 10.4103/0028-3886.250719
  11. Tandon A., Khullar T., Maheshwari S. et al. High resolution ultrasound in subclinical diabetic neuropathy: A potential screening tool. Ultrasound. 2021; 29 (3): 150–61. doi: 10.1177/1742271X20958034
  12. Wang K., Yu D., Yao T. et al. Retrospective study of the ultrasound characteristics of the tibial nerve in patients with type 2 diabetic peripheral neuropathy. Ann Palliat Med. 2021; 10 (8): 8787–96. doi: 10.21037/apm-21-1573
  13. Wang C., Wang H., Zhou Y. et al. Evaluation of the clinical value of shear wave elastography for early detection and diagnosis of diabetic peripheral neuropathy: a controlled preliminary prospective clinical study. BMC Musculoskelet Disord. 2022; 23 (1): 1120. doi: 10.1186/s12891-022-06085-z
  14. Zakrzewski J., Zakrzewska K., Pluta K. et al. Ultrasound elastography in the evaluation of peripheral neuropathies: a systematic review of the literature. Pol J Radiol. 2019; 84: e581–e591. doi: 10.5114/pjr.2019.91439
  15. Kallinikou D., Soldatou A., Tsentidis C. et al. Diabetic neuropathy in children and adolescents with type 1 diabetes mellitus: Diagnosis, pathogenesis, and associated genetic markers. Diabetes Metab Res Rev. 2019; 35 (7): e3178. doi: 10.1002/dmrr.3178
  16. Sloan G., Selvarajah D., Tesfaye S. Pathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy. Nat Rev Endocrinol. 2021; 17: 400–20. doi: 10.1038/s41574-021-00496-z
  17. Aslan M., Aslan A., Emeksiz H.C. et al. Assessment оf Peripheral Nerves With Shear Wave Elastоgraphy in Type 1 Diabetic Adоlescents Withоut Diabetic Peripheral Neurоpathy. J Ultrasоund Med. 2019; 38 (6): 1583–96. doi: 10.1002/jum.14848
  18. Blair J., McKay A., Ridyard C. et al. Continuous subcutaneous insulin infusion versus multiple daily injections in children and young people at diagnosis of type 1 diabetes: the SCIPI RCT. Health Technol Assess. 2018; 22 (42): 1–112. doi: 10.3310/hta22420
  19. Cole J.B., Florez J.C. Genetics of diabetes mellitus and diabetes complications. Nat Rev Nephrol. 2020; 16 (7): 377–90. doi: 10.1038/s41581-020-0278-5
  20. Gencpinar P., Çelmeli G., Duman Ö. et al. Tibial nerve axonal excitability in type 1 diabetes mellitus. Muscle Nerve. 2019; 59 (1): 76–81. doi: 10.1002/mus.26303

Supplementary files

Supplementary Files
Action
1. JATS XML
Download
2. Fig. 1. Dynamics of the cross-sectional area (Median) of the nerves of the lower extremities in patients with different durations of type 1 diabetes mellitus and the control group, aged 7–12 and 13–17 years (nonparametric comparison, Kruskal–Wallis test)

Download (85KB)
Indexing metadata
3. Fig. 2. Dynamics of the stiffness index (median) of the nerves of the lower extremities in patients with different durations of type 1 diabetes mellitus and the control group, aged 7–12 and 13–17 years (nonparametric comparison, Kruskal–Wallis test)

Download (90KB)
Indexing metadata

Copyright (c) 2024 Russkiy Vrach Publishing House

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies