Disorders of the fatty acid spectrum of erythrocytes and blood plasma of adolescents with recurrent cephalgia associated with hypertension: approaches to correction

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Abstract

The spectrum of fatty acids (FA) in erythrocytes and blood plasma reflects the characteristics of lipid metabolism in diseases of vascular origin, including cephalalgia associated with arterial hypertension (AH). Timely diagnosis and correction of violations of this spectrum is important for the prevention of diseases of the cardiovascular and nervous system in subsequent age periods of life.

Objective. To study the characteristics of the FA spectrum of erythrocyte membranes and blood plasma in adolescents with recurrent cephalalgia associated with AH.

Material and methods. The composition of FA of erythrocytes and blood plasma was studied in 51 adolescents aged 12–18 years with recurrent cephalgia associated with AH and without AH. Determination of the FA composition of erythrocytes and blood plasma was carried out by gas-liquid chromatography-mass spectrometry with preliminary lipid extraction according to the Folch method. The analysis of FA methyl esters was carried out on a gas chromatograph with a GCD Plus mass spectrometric detector (Hewlett-Packard, USA).

Results. The features of the structural redistribution of individual FA in adolescents with cephalgia and AH in the form of a predominance of saturated and monoenic FA in erythrocytes with a simultaneous decrease in their content in blood plasma, as well as a tendency to a decrease in the concentration of polyunsaturated FA in erythrocytes and their increase in plasma.

Conclusion. Early detection and timely correction of disorders of the FA spectrum of erythrocyte membranes and blood plasma is necessary, starting from childhood and adolescence, in order to subsequently reduce the risk of developing diseases of the cardiovascular and nervous system associated with these disorders.

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About the authors

L. S. Evert

Federal Research Center «Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences», Research Institute of Medical Problems of the North; N.F. Katanov Khakass State University, Ministry of Education and Science of Russia

Email: potupchik_tatyana@mail.ru

MD

Russian Federation, Krasnoyarsk; Abakan

T. V. Potupchik

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia

Author for correspondence.
Email: potupchik_tatyana@mail.ru

Сandidate of Medical Sciences

Russian Federation, Krasnoyarsk

Yu. R. Kostyuchenko

Federal Research Center «Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences», Research Institute of Medical Problems of the North

Email: potupchik_tatyana@mail.ru
Russian Federation, Krasnoyarsk

I. A. Ignatova

Federal Research Center «Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences», Research Institute of Medical Problems of the North

Email: potupchik_tatyana@mail.ru

MD

Russian Federation, Krasnoyarsk

V. G. Teslenko

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia

Email: potupchik_tatyana@mail.ru
Russian Federation, Krasnoyarsk

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2. Fig. 1. Absolute level of fatty acids in erythrocyte membranes and blood plasma in the study groups

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3. Fig. 2. Relative level of fatty acids in erythrocyte membranes and blood plasma in the study groups

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