The effect of nonsteroidal anti-inflammatory drugs on cartilage tissue

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Abstract

The article presents a review of studies on the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on cartilage tissue. Most studies have shown that non-selective NSAIDs, especially with prolonged use, negatively affect cartilage, accelerate cartilage destruction, inhibit prostaglandin synthesis, chondrocyte proliferation, and inhibit enzymes necessary for the synthesis of glycosaminoglycans. Cyclooxygenase-2 selective drugs have a positive effect on the condition of the cartilage matrix. However, taking into account some contradictions and insufficient information from the scientific literature of recent years, the need for further scientific research in this direction is emphasized.

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About the authors

Т. V. Potupchik

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia

Author for correspondence.
Email: potupchik_tatyana@mail.ru

Сandidate of Medical Sciences

Russian Federation, Krasnoyarsk

E. V. Kapustina

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia; Krasnoyarsk Regional Clinical Hospital

Email: potupchik_tatyana@mail.ru

Сandidate of Medical Sciences

Russian Federation, Krasnoyarsk; Krasnoyarsk

Е. P. Klyuchnikova

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia; Krasnoyarsk Regional Clinical Hospital

Email: potupchik_tatyana@mail.ru
Russian Federation, Krasnoyarsk; Krasnoyarsk

V. V. Oskina

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia

Email: potupchik_tatyana@mail.ru
Russian Federation, Krasnoyarsk

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