Emollients in psoriasis therapy

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Abstract

Objective. To study the efficacy of Blue Cap emollient in patients with psoriasis.

Material and methods. The study included 10 patients with psoriasis vulgaris, limited form, stationary stage. Patients were divided into 2 groups: 1st (n=5) – patients received basic therapy (betamethasone + calcipotriol ointment once a day for 2 weeks) against the background of emollient application (containing piroctonolamine, bisabolol, ceramides, cholesterol, phytosphingosine, glycerol, glyceryl stearate); 2nd (n=5) - patients received only basic therapy. The severity of the course of psoriasis and the effectiveness of therapy according to clinical signs were assessed using the Psoriasis Area and Severity Index (PASI). The severity of pruritus and the impact of pruritus on patients' quality of life were assessed using the Behavioral rating scores (BRS) questionnaire and the pruritus index “Prurindex”.

Results. Inclusion of Blue Cap emollient into the treatment protocol of psoriasis patients against the background of basic therapy (betamethasone + calcipotriol) promoted a significant decrease in PASI and improvement of skin condition in comparison with the group receiving only basic therapy.

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About the authors

Е. V. Sorokina

I.I. Mechnikov Research Institute of Vaccines and Serums, Russian Academy of Medical Sciences; Academy of Postgraduate Education under the Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies of the Federal Medical Biological Agency

Author for correspondence.
Email: sorokina-cathrine@yandex.ru
ORCID iD: 0000-0002-1188-6578

MD

Russian Federation, Moscow; Moscow

E. А. Akhmatova

I.I. Mechnikov Research Institute of Vaccines and Serums, Russian Academy of Medical Sciences

Email: sorokina-cathrine@yandex.ru
ORCID iD: 0000-0002-9073-5291
Russian Federation, Moscow

Е. Yu. Sentsova

P.A. Herzen Moscow Cancer Research Institute, Ministry of Health of Russia

Email: sorokina-cathrine@yandex.ru
ORCID iD: 0009-0002-2586-633X
Russian Federation, Moscow

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2. Fig. 1. Patient R., 38 years old (diagnosed with psoriasis vulgaris, stationary stage), foci on the dorsal surface of the right hand: a – before treatment; б – after 1 month of treatment (ointment containing betamethasone and calcipotriol, against the background of emollient application)

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3. Fig. 2. Patient R., 38 years old (diagnosed with psoriasis vulgaris, stationary stage), foci in the area of elbow joints: a – before treatment; б – after 1 month of treatment (ointment containing betamethasone and calcipotriol, against the background of emollient application)

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4. Fig. 3. Patient R., 38 years old (diagnosed with psoriasis vulgaris, stationary stage), foci in the area of the dorsal surface of the right foot: a – before treatment; б – after 1 month of treatment (ointment containing betamethasone and calcipotriol, against the background of emollient application)

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