The effect of infectious agents on the development and course of chronic idiopathic urticaria

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The article analyzes the infectious load in patients with chronic spontaneous urticaria. The authors analyzed virological and bacteriological laboratory data, assessed the level of infectious load, and identified possible associations with specific types of infections. The results of the study showed that clinical and/or laboratory signs of activity of bacterial agents were observed in 40.66% of patients, signs of activity of viral agents - in 21.43%, combined bacterial-viral pathology - in 23.08%, clinical and laboratory signs of activity of infectious agents were absent in 14.83% of patients. It has been found that certain types of infections, such as herpes simplex virus type 1 and type 2, Epstein-Barr virus, human herpes virus type 6, Helicobacter pylori, can be closely associated with the manifestation of urticaria. The study highlights the importance of studying the infectious load in this nosology in order to develop personalized approaches to the treatment and management of this disease.

About the authors

A. I. Golovinov

Branch No. 8 of N.N. Burdenko Main Military Clinical Hospital, Ministry of Defense of Russia

Author for correspondence.
Email: golovinov78@mail.ru
Russian Federation, Khimki

V. V. Gladko

Russian Biotechnical University, Medical Institute of Continuing Education

Email: golovinov78@mail.ru

Professor, MD

Russian Federation, Moscow

E. V. Sorokina

I.I. Mechnikov Scientific Research Institute of Vaccines and Serums; Academy of Postgraduate Education of Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies of the Federal Medical and Biological Agency

Email: golovinov78@mail.ru

Professor, MD

Russian Federation, Moscow; Moscow

G. L. Belyakova

LLC "Lekar"

Email: golovinov78@mail.ru
Russian Federation, Krasnogorsk

References

  1. Wedi B., Raap U., Wieczorek D. et al. Urticaria and infections. Allergy Asthma Clin Immunol. 2009; 5 (1): 10. doi: 10.1186/1710-1492-5-10
  2. Bonner J.R. Clinical Methods: The History, Physical, and Laboratory Examinations, 3rd ed. Boston: Butterworths; 1990.
  3. Zuberbier T., Abdul Latiff A.H., Abuzakouk M. et al. The international EAACI/GA2LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria. Allergy. 2022; 77 (3): 734–66. doi: 10.1111/all.15090
  4. Данилычева И.В. Хроническая спонтанная крапивница: диагностические терапевтические аспекты. Дисс. … канд. мед. наук. М., 2022 [anilycheva I.V. Chronic spontaneous urticaria: diagnostic therapeutic aspects. Diss. ... kand. med. nauk. М., 2022 (in Russ.)].
  5. Gu H., Li L., Gu M. et al. Association between Helicobacter pylori Infection and Chronic Urticaria: A Meta-Analysis. Gastroenterol Res Pract. 2015; 2015: 486974. doi: 10.1155/2015/486974
  6. Dennis M.F., Mavura D.R., Kini L. et al. Association between Chronic Urticaria and Helicobacter pylori Infection among Patients Attending a Tertiary Hospital in Tanzania. Dermatol Res Pract. 2020; 2020: 5932038. doi: 10.1155/2020/5932038
  7. Watanabe J., Shimamoto J., Kotani K. The Effects of Antibiotics for Helicobacter pylori Eradication or Dapsone on Chronic Spontaneous Urticaria: A Systematic Review and Meta-Analysis. Antibiotics (Basel). 2021; 10 (2): 156. doi: 10.3390/antibiotics10020156
  8. Sharma A.D. Role of Nasal Carriage of Staphylococcus aureus in Chronic Urticaria. Indian J Dermatol. 2012; 57 (3): 233–6. doi: 10.4103/0019-5154.96211
  9. Konstantinou G.N., Sagonas I., Giannoula F.C. Chronic Spontaneous and Inducible Urticaria Associated With Mycoplasma pneumoniae Infection. Cureus. 2021; 13 (10): e18746. doi: 10.7759/cureus.18746
  10. Mareri A., Adler S.P., Nigro G. Herpesvirus-associated acute urticaria: an age matched case-control study. PLoS One. 2013; 27 (8): e85378. doi: 10.1371/journal.pone.0085378
  11. Kasperska-Zając A., Damasiewicz-Bodzek A., Grzanka R. et al. Circulating soluble LIGHT/TNFSF14 is increased and associated with IL-8 concentration in chronic spontaneous urticaria. Int J Immunopathol Pharmacol. 2018; 32: 2058738418784431. doi: 10.1177/2058738418784431
  12. Kaplan A.P. Diagnosis and treatment of chronic spontaneous urticaria. Allergy. 2020; 75 (7): 1830–2. doi: 10.1111/all.14192
  13. Bansal C.J., Bansal A.S. Stress, pseudoallergens, autoimmunity, infection and inflammation in chronic spontaneous urticaria. Allergy Asthma Clin Immunol. 2019; 15: 56. doi: 10.1186/s13223-019-0372-z
  14. Dreyfus D.H. Serological evidence that activation of ubiquitous human herpesvirus-6 (HHV-6) plays a role in chronic idiopathic/spontaneous urticaria (CIU). Clin Exp Immunol. 2016; 183 (2): 230–8. doi: 10.1111/cei.12704
  15. Caserta M.T., Hall C.B., Canfield R.L. et al. Early developmental outcomes of children with congenital HHV-6 infection. Pediatrics. 2014; 134 (6): 1111–8. doi: 10.1542/peds.2014-0886
  16. Kouzuki K., Kato I., Kato T. et al. Epileptic encephalopathy associated with human herpesvirus 6 (HHV-6) encephalitis after the second cord blood transplantation in a patient with pediatric acute lymphoblastic leukemia. Rinsho Ketsueki. 2014; 55 (12): 2418–22. doi: 10.11406/rinketsu.55.2418
  17. Imbalzano E., Casciaro M., Quartuccio S. et al. Association between urticaria and virus infections: a systematic review. Allergy Asthma Proc. 2016; 37 (1): 18–22. doi: 10.2500/aap.2016.37.3915
  18. Marone G., Rossi F.W., Detoraki A. et al. Role of superallergens in allergic disorders. Chem Immunol Allergy. 2007; 93: 195–213. doi: 10.1159/000100896
  19. Cozzani E., Herzum A., Burlando M. et al. Cutaneous manifestations of HAV, HBV, HCV. Ital J Dermatol Venerol. 2021; 156 (1): 5–12. doi: 10.23736/S2784-8671.19.06488-5
  20. Chuamanochan M., Chiewchanvit S., Tovanabutra N. et al. A case of dengue fever presenting with acute urticaria. Asian Pac J Allergy Immunol. 2022; 40 (1): 72–4. doi: 10.12932/AP-150419-0539
  21. Saini S.S. Chronic spontaneous urticaria: etiology and pathogenesis. Immunol Allergy Clin North Am. 2014; 34 (1): 33–52. doi: 10.1016/j.iac.2013.09.012
  22. Wu C.-H., Eren E., Ardern-Jones M.R. et al. Association between Micronutrient Levels and Chronic Spontaneous Urticaria. Biomed Res Int. 2015; 2015: 926167. doi: 10.1155/2015/926167
  23. Johal K.J., Saini S.S. Current and emerging treatments for chronic spontaneous urticaria. Ann Allergy Asthma Immunol. 2020; 125 (4): 380–7. doi: 10.1016/j.anai.2019.08.465

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2024 Russkiy Vrach Publishing House

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies