Differential diagnosis of exanthems in infectious mononucleosis (clinical case)

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详细

The article presents a description of a clinical case of infectious mononucleosis with pronounced exanthema in an 18-year-old female patient. The patient's clinical status is analyzed, and a detailed differential diagnosis is conducted with syndrome-similar diseases. The most significant clinical symptoms present in the typical picture of infectious mononucleosis are highlighted. The article discusses the significance of determining antibody avidity for diagnosing the stage of the infectious process. Particular attention is paid to the importance of determining this parameter in pregnant women, where diagnostic accuracy and assessment of disease severity are crucial for making decisions about patient management.

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作者简介

M. Mirolaev

Patrice Lumumba Peoples' Friendship University of Russia

编辑信件的主要联系方式.
Email: mikhailmirolaev@yandex.ru
ORCID iD: 0009-0006-4748-7823
俄罗斯联邦, Moscow

L. Kotlinskaya

Russian University of Medicine, Ministry of Health of Russia

Email: mikhailmirolaev@yandex.ru
ORCID iD: 0009-0004-1406-458X
俄罗斯联邦, Moscow

O. Burgasova

Patrice Lumumba Peoples' Friendship University of Russia

Email: mikhailmirolaev@yandex.ru
ORCID iD: 0000-0002-5486-0837

MD, Professor

俄罗斯联邦, Moscow

R. Khodzhibekov

Patrice Lumumba Peoples' Friendship University of Russia

Email: mikhailmirolaev@yandex.ru
ORCID iD: 0000-0001-9703-8459

Candidate of Medical Sciences

俄罗斯联邦, Moscow

参考

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  2. Собчак Д.М. и др. ВЭБ-инфекция (этиология, патогенез, клиника, диагностика, лечение): учебное пособие. Нижний Новгород: Издательство НижГМА, 2010 [Sobchak D.M. et al. VEB-infection (etiology, pathogenesis, clinic, diagnosis, treatment): textbook. Nizhny Novgorod: Nizhny Novgorod State Medical Academy Publishing House, 2010 (in Russ.)].
  3. Манкевич Р.Н., Романова О.Н., Астапов А.А. Дифференциальная диагностика инфекционных экзантем у детей: учебно-методическое пособие. Минск: БГМУ, 2022; 52 с. [Mankevich R.N., Romanova O.N., Astapov A.A. Differential diagnostics of infectious exanthems in children: teaching manual. Minsk: BSMU, 2022; 52 p. (in Russ.)].
  4. Клинические рекомендации (протокол лечения) оказания медицинской помощи детям больным инфекционным мононуклеозом. ФГБУ НИИДИ ФМБА России, 2013 [Clinical recommendations (treatment protocol) of medical care for children with infectious mononucleosis. FGBU NIIDI FMBA of Russia, 2013 (in Russ.)].
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  6. Dondi A., Parladori R., Mori F. et al. Viral rashes mimicking drug reaction with eosinophilia and systemic symptoms syndrome in children after β-lactams intake: a diagnostic challenge. Eur J Pediatr. 2021; 180 (7): 2327–32. doi: 10.1007/s00431-021-04010-5
  7. Bodéus M., Feyder S., Goubau P. Avidity of IgG antibodies distinguishes primary from non-primary cytomegalovirus infection in pregnant women. Clin Diagn Virol. 1998; 9 (1): 9–16. doi: 10.1016/s0928-0197(97)10016-2
  8. Коровина Н.А. и др. Цитомегаловирусная инфекция у детей раннего возраста (клиника, диагностика, современные возможности терапии): руководство для врачей. 2-е изд., перераб. и доп. М.: Медпрактика, 2001 [Korovina N.A. et al. Cytomegalovirus infection in young children (clinic, diagnostics, modern possibilities of therapy): a guide for doctors. 2nd ed., revision and supplement. М.: Medpraktika, 2001 (in Russ.)].

补充文件

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1. JATS XML
2. Patient N., 18 years old, day 9 of the disease: a – patchy-papular rash on the upper limb; б – patchy-papular rash on the skin of the back, lumbar region

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