On the possibility of creating a universal scale for assessing wound healing

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Abstract

Wound healing is a process that is crucial in maintaining the barrier function of the skin and preserving its other functions. Healing occurs by regeneration or reconstruction of damaged tissue. Reparation of the skin is a difficult multifactorial biological process, covering both the regeneration of structural components and the restoration of the functional characteristics of the skin. There are scales that allow you to evaluate the progress of the restoration of the skin barrier. However, during their clinical test and further use, certain shortcomings were identified. Thus, there is a tendency to create a universal scale of wound healing, which will have diagnostic and prognostic value.

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About the authors

A. M. Morozov

Tver State Medical University

Author for correspondence.
Email: ammorozovv@gmail.com
ORCID iD: 0000-0003-4213-5379
SPIN-code: 6815-9332

Candidate of Medical Sciences

Russian Federation, Tver

K. D. Sheina

Tver State Medical University

Email: ammorozovv@gmail.com
ORCID iD: 0009-0009-2374-0566
SPIN-code: 4324-4331
Russian Federation, Tver

References

  1. He W., Wang X., Hang T. et al. Fabrication of Cu2+-loaded phase-transited lysozyme nanofilm on bacterial cellulose: Antibacterial, anti-inflammatory, and pro-angiogenesis for bacteria-infected wound healing. Carbohydrate Polymers. 2023; 309: 120681. doi: 10.1016/j.carbpol.2023.120681
  2. Ahmad N. In Vitro and In Vivo Characterization Methods for Evaluation of Modern Wound Dressings. Pharmaceutics. 2023; 15 (1): 42. doi: 10.3390/pharmaceutics15010042
  3. Sadeghi-Aghbash M., Rahimnejad M., Adeli H. et al. Wound Healing: An Overview of Wound Dressings on Health Care. Curr Pharm Biotechnol. 2023; 24 (9): 1079–93. doi: 10.2174/1389201023666220913153725
  4. Shaw T.J., Martin P. Wound repair at a glance. J Cell Sci. 2009; 122 (18): 3209–13. doi: 10.1242/jcs.031187
  5. Velnar T., Bailey T., Smrkolj V. The Wound Healing Process: An Overview of the Cellular and Molecular Mechanisms. J Int Med Res. 2009; 37 (5): 1528–42. doi: 10.1177/147323000903700531
  6. Rennekampff H.O., Fimmers R., Metelmann, H.R. et al. Reliability of photographic analysis of wound epithelialization assessed in human skin graft donor sites and epidermolysis bullosa wounds. Trials. 2015; 16: 235. doi: 10.1186/s13063-015-0742-x
  7. Goldman R.J., Salcido R. More than one way to measure a wound: an overview of tools and techniques. Adv Skin Wound Care. 2002; 15 (5): 236–43. doi: 10.1097/00129334-200209000-00011
  8. Haj Yahya B., Chaushu G., Hamzani Y. Evaluation of wound healing following surgical extractions using the IPR Scale. Int Dent J. 2020; 71 (2): 133–9. doi: 10.1111/idj.12622
  9. Hamzani Y., Chaushu G. Evaluation of early wound healing scales/indexes in oral surgery: A literature review. Clin Implant Dent Relat Res. 2018; 20 (6): 1030–5. doi: 10.1111/cid.12680
  10. Davidoss N.H., Eikelboom R., Friedland P.L. et al. Wound healing after tonsillectomy – a review of the literature. J Laryngol Otol. 2018; 132 (9): 764–70. doi: 10.1017/S002221511800155X
  11. Lazarus G.S., Cooper D.M., Knighton D.R. et al. Definitions and guidelines for assessment of wounds and evaluation of healing. Wound Repair and Regeneration. 1994; 2 (3): 165–70. doi: 10.1046/j.1524-475X.1994.20305.x
  12. Gupta A., Kumar P. Assessment of the histological state of the healing wound. Plastic and Aesthetic Research. 2015; 2: 239–42. doi: 10.4103/2347-9264.158862
  13. Garbuio D.C., Zamarioli C.M., Silva N.C.M. et al. Assessment tools for the healing of wounds: an integrative review. Revista Eletrônica De Enfermagem 20. 2018; 20: 1–16. doi: 10.5216/REE.V20.49425
  14. Wysocki A.B. Wound measurement. Int J Dermatol. 1996; 35 (2): 82–91. doi: 10.1111/j.1365-4362.1996.tb03266.x
  15. Sharma A., Khanna S., Kaur,G. et al. Medicinal plants and their components for wound healing applications. Future Journal of Pharmaceutical Sciences. 2021; 7: 53. doi: 10.1186/s43094-021-00202-w
  16. Childs D.R., Murthy A.S. Overview of Wound Healing and Management. Surg Clin North Am. 2017; 97 (1): 189–207. doi: 10.1016/j.suc.2016.08.013
  17. Chamgordani Z., Tabatabaei N.S, Mortazavi M. et al. An overview of wound healing: wound types and current therapeutics. In book: Bioengineered Nanomaterials for Wound Healing and Infection Control. 2023; 10. doi: 10.1016/B978-0-323-95376-4.00007-1
  18. Морозов А.М., Сергеев А.Н., Сергеев Н.А. и др. Современные методы стимуляции процесса регенерации послеоперационных ран. Сибирское медицинское обозрение. 2020; 3: 54–60 [Morozov A.M., Sergeev A.N., Sergeev N.A. et al. Modern methods of stimulating process of postoperative wounds regeneration. Siberian Medical Review. 2020; 3: 54–60 (in Russ.)]. doi: 10.20333/2500136-2020-3-54-60
  19. Тамразова О.Б. Факторы риска развития атопического дерматита у грудных детей и первичная профилактика заболевания. Медицинский Совет. 2018; 17: 182–7 [Tamrazova O.В. Atopic dermatitis: risk factors for disease development in infants and primary prevention of the disease. Medical Council. 2018; 17: 182–7 (in Russ.)]. doi: 10.21518/2079-701X-2018-17-182-186
  20. Yiblet T.G., Tsegaw A., Ahmed N. et al. Evaluation of Wound Healing Activity of 80% Methanol Root Crude Extract and Solvent Fractions of Stephania abyssinica (Dill. & A. Rich.) Walp. (Menispermaceae) in Mice. J Exp Pharmacol. 2022; 14: 255–73. doi: 10.2147/JEP.S364282
  21. Муромцева Е.В., Сергацкий К.И., Никольский В.И. и др. Лечение ран в зависимости от фазы раневого процесса. Известия высших учебных заведений. Поволжский регион. Медицинские науки. 2022; 3: 93–10. [Muromtseva E.V., Sergatskiy K.I., Nikol'skiy V.I. et al. Wound treatment depending on the phase of the wound process. University proceedings. Volga region. Medical sciences. 2022; 3: 93–109 (in Russ.)]. doi: 10.21685/2072-3032-2022-3-9
  22. Фролов С.А., Кузьминов А.М., Вышегородцев Д.В. и др. Возможности применения низкотемпературной аргоновой плазмы в лечении послеоперационных и длительно незаживающих ран. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2019; 29 (6): 15–21 [Frolov S.A., Kuzminov A.M., Vyshegorodtsev D.V. et al. Possibilities for the application of low-temperature argon plasma in the treatment of postoperative and long-term non-healing wounds. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2019; 29 (6): 15–21 (in Russ.)]. doi: 10.22416/1382-4376-2019-29-6-15-21
  23. Zheng L., Li S., Luo J. et al. Latest Advances on Bacterial Cellulose-Based Antibacterial Materials as Wound Dressings. Front Bioeng Biotechnol. 2022; 8: 593768. doi: 10.3389/fbioe.2020.593768
  24. Coge V., Million N., Rehbock C. et al. Tissue Concentrations of Zinc, Iron, Copper, and Magnesium During the Phases of Full Thickness Wound Healing in a Rodent Model. Biol Trace Elem Res. 2019; 191: 167–76. doi: 10.1007/s12011-018-1600-y
  25. Mills S.J., Hofma, B.R., Cowin, A.J. Pathophysiology of Wound Healing. In: Fitridge, R. (eds) Mechanisms of Vascular Disease. Springer, Cham. 2020; pp. 541–61. doi: 10.1007/978-3-030-43683-4_25
  26. Trinh X.T., Long N.V., Van Anh L.T. et al. A Comprehensive Review of Natural Compounds for Wound Healing: Targeting Bioactivity Perspective. Int J Mol Sci. 2022; 23 (17): 9573. doi: 10.3390/ijms23179573
  27. Marconi G.D., Fonticoli L., Rajan T.S. et al. Epithelial-Mesenchymal Transition (EMT): The Type-2 EMT in Wound Healing, Tissue Regeneration and Organ Fibrosis. Cells. 2021; 10 (7): 1587. doi: 10.3390/cells10071587
  28. Simmons J. Wound Healing and Assessment. J Dermatol Nurs Assoc. 2022; 14 (5): 197–202. doi: 10.1097/JDN.0000000000000704
  29. Burnet M., Metcalf D.G., Milo S. et al. A Host-Directed Approach to the Detection of Infection in Hard-to-Heal Wounds. Diagnostics. 2022; 12 (10): 2408. doi: 10.3390/diagnostics12102408
  30. Kloc M., Ghobrial R.M., Wosik J. et al. Macrophage functions in wound healing. J Tissue Eng Regen Med. 2019; 13 (1): 99–109. doi: 10.1002/term.2772
  31. Pizzicannella J., Diomede F., Merciaro I. et al. Endothelial committed oral stem cells as modelling in the relationship between periodontal and cardiovascular disease. J Cell Physiol. 2018; 233 (10): 6734–47. doi: 10.1002/jcp.26515
  32. Li J., Chen J., Kirsner R. Pathophysiology of acute wound healing. Clin Dermatol. 2007; 25 (1): 9–18. doi: 10.1016/j.clindermatol.2006.09.007
  33. Bowden L.G., Byrne H.M., Maini P.K. et al. A morphoelastic model for dermal wound closure. Biomech Model Mechanobiol. 2016; 15: 663–81. doi: 10.1007/s10237-015-0716-7
  34. Wilkinson H.N., Hardman M.J. Wound healing: cellular mechanisms and pathological outcomes. Open Biol. 2020; 10 (9): 200223. doi: 10.1098/rsob.200223
  35. Gurtner G.C., Werner S., Barrandon Y. et al. Wound repair and regeneration. Nature. 2008; 453 (7193): 314–21. doi: 10.1038/nature07039
  36. Yang Y., Li B., Wang M. et al. Effect of natural polymer materials on skin healing based on internal wound microenvironment: a review. Front Chem. 2023; 11: 1257915. doi: 10.3389/fchem.2023.1257915
  37. Shamsian N. Wound bed preparation: an overview. Br J Community Nurs. 2021; 26 (Sup 9): 6–11. doi: 10.12968/bjcn.2021.26.Sup9.S6
  38. Lalonde D., Joukhadar N., Janis J. Simple Effective Ways to Care for Skin Wounds and Incisions. Plast Reconstr Surg Global Open. 2020; 8 (2): 2727. doi: 10.1097/GOX.0000000000002727
  39. Морозов А.М., Жуков С.В., Беляк М.А. и др. Оценка экономических потерь вследствие развития инфекции области хирургического вмешательства. Менеджер здравоохранения. 2022; 1: 54–60 [Morozov A.M., Zhukov S.V., Belyak M.A. et al. Estimation of economic losses due to the development of infection of the area of surgical intervention. Health Care Manager. 2022; 1: 54–60 (in Russ)]. doi: 10.21045/1811-0185-2022-1-54-60
  40. Морозов А.М., Сергеев А.Н., Кадыков В.А. и др. Хронический болевой синдром, факторы риска развития на этапах хирургического вмешательства. Сибирское медицинское обозрение. 2021; 5: 5–13 [Morozov A.M., Sergeev A.N., Kadykov V.A. et al. Chronic pain syndrome, risk factors of development at the stages of surgical intervention. Siberian Medical Review. 2021; 5: 5–13 (in Russ.)]. doi: 10.20333/25000136-2021-5-5-13
  41. Maheswary T., Nurul A.A., Fauzi M.B. The Insights of Microbes’ Roles in Wound Healing: A Comprehensive Review. Pharmaceutics. 2021; 13 (7): 981. doi: 10.3390/pharmaceutics13070981.
  42. McLeod M., Nouri K., Elsaie M. Secondary Intention Healing. Dermatologic Surgery: Step by Step. 2012; pp. 69–73. doi: 10.1002/9781118412633.ch13
  43. dos Santos Alves D.F., de Almeida A.O., Gomes Silva J.L. et al. Translation and adaptation of the bates-jensen wound assessment tool for the brazilian culture. Texto & Contexto – Enfermagem. 2015; 24 (3): 826–33. doi: 10.1590/0104-07072015001990014
  44. Морозов А.М., Сергеев А.Н., Аскеров Э.М. и др. О возможности использования модернизированной шкалы боли в клинической практике. Современные проблемы науки и образования. 2020; 5: 81 [Morozov A.M., Sergeev A.N., Askerov E.M. et al. About the possibility of using the modernized pain scale in clinical practice. Modern Problems of Science and Education. 2020; 5: 81 (in Russ)]. doi: 10.17513/spno.30010
  45. Wilson A.P.R., Sturridge M.F., Treasure T. et al. A scoring method (asepsis) for postoperative wound infections for use in clinical trials of antibiotic prophylaxis. Lancet. 1986; 327 (8476): 311–2. doi: 10.1016/S0140-6736(86)90838-X
  46. Bruce J., Russell E.M., Mollison J. et al. The quality of measurement of surgical wound infection as the basis for monitoring: a systematic review. J Hosp Infect. 2001; 49 (2): 99–108. doi: 10.1053/jhin.2001
  47. Siah C.J., Childs C. A systematic review of the ASEPSIS scoring system used in non-cardiac-related surgery. J Wound Care. 2012; 21 (3): 124–30. doi: 10.12968/jowc.2012.21.3.124
  48. Copanitsanou P., Kechagias V.A., Grivas T.B. et al. Use of ASEPSIS scoring method for the assessment of surgical wound infections in a Greek orthopaedic department. Int J Orthop Trauma Nurs. 2018; 30: 3–7. doi: 10.1016/j.ijotn.2018.03.003
  49. Bailey I.S., Karran S.E., Toyn K. et al. Community surveillance of complications after hernia surgery. BMJ. 1992; 304: 469. doi: 10.1136/bmj.304.6825.469
  50. Sanada H., Iizaka S., Matsui Y. et al. Scientific Education Committee of the Japanese Society of Pressure Ulcers. Clinical wound assessment using DESIGN-R total score can predict pressure ulcer healing: pooled analysis from two multicenter cohort studies. Wound Repair Regen. 2011; 19 (5): 559–67. doi: 10.1111/j.1524-475X.2011.00719.x
  51. Bates-Jensen B. The pressure sore status tool: An outcome measure for pressure sores. Topics in Geriatric Rehabilitation. 1994; 9: 17–34. doi: 10.1097/00013614-199406000-00005
  52. Bates-Jensen wound assessment tool. Instructions for use. URL: https://aci.health.nsw.gov.au/__data/assets/pdf_file/0010/388243/22.-Bates-Jensen-wound-assessment-tool-BWAT.pdf
  53. Ferrell B.A., Artinian B.M., Sessing D. The Sessing scale for assessment of pressure ulcer healing. J Am Geriatr Soc. 1995; 43 (1): 37–40. doi: 10.1111/j.1532-5415.1995.tb06239.x
  54. Bates-Jensen B.M., Vredevoe D.L., Brecht M.L. Validity and reliability of the Pressure Sore Status Tool. Decubitus. 1992; 5 (6): 20–8.
  55. Harris C., Bates-Jensen B., Parslow N. et al. Bates-Jensen wound assessment tool: pictorial guide validation project. J Wound Ostomy Continence Nurs. 2010; 37 (3): 253–9. doi: 10.1097/WON.0b013e3181d73aab
  56. Gupta S., Srivastava A., Malhotra R. et al. Wound Assessment Using Bates Jensen Wound Assessment Tool in Acute Musculoskeletal Injury Following Low-Cost Wall-Mounted Negative-Pressure Wound Therapy Application. Indian J Orthop. 2023; 57 (6): 948–56. doi: 10.1007/s43465-023-00861-2
  57. Bates-Jensen B.M., McCreath H.E., Harputlu D. et al. Reliability of the Bates-Jensen wound assessment tool for pressure injury assessment: The pressure ulcer detection study. Wound Repair Regen. 2019; 27 (4): 386–95. doi: 10.1111/wrr.12714
  58. Macedo A., Graciotto A., Souza E. et al. Pressure ulcers: correlation between the bates-jensen wound assessment tool and the pressure ulcer scale for healing. Texto & Contexto Enfermagem. 2021; 30: 20200260. doi: 10.1590/1980-265X-TCE-2020-0260.
  59. Rubenstein L.Z., Powers C.M., MacLean C.H. Quality indicators for the management and prevention of falls and mobility problems in vulnerable elders. Ann Intern Med. 2001; 135: 686–93. doi: 10.7326/0003-4819-135-8_part_2-200110161-00007
  60. Sandeep B., Shashikumara P., Prathima C. et al. The sessing scale for assessment of chronic grade II diabetic foot ulcer healing. Nat J Physiol Pharm Pharmacol. 2021; 11: 283–7. doi: 10.5455/njppp.2021.11.11309202001612020
  61. NPUAP. Pressure ulcers get new terminology and staging definitions. Department: wound & skin care. Nursing. 2019; 47 (3): 68–9. doi: 10.1097/01.NURSE.0000512498.50808.2b
  62. Santos V.L.C.G., Sellmer D., Massulo M.M.E. Inter rater reliability of Pressure Ulcer Scale for Healing (PUSH) in patients with chronic leg ulcers. Rev Latino-am Enfermagem. 2007; 15 (3): 391–6. doi: 10.1590/S0104-11692007000300005
  63. Stotts N., Rodeheaver G., Thomas D. et al. An Instrument to Measure Healing in Pressure Ulcers: Development and Validation of the Pressure Ulcer Scale for Healing (PUSH). J Gerontol A Biol Sci Med Sci. 2001; 56 (12): 795–9. DOI: 0.1093/gerona/56.12.M795
  64. Gardner S.E., Frantz R.A., Bergquist S. et al. A Prospective Study of the Pressure Ulcer Scale for Healing (PUSH). J Gerontol A Biol Sci Med Sci. 2005; 60 (1): 93–7. doi: 10.1093/gerona/60.1.93
  65. Sussman C., Bates-Jensen B.M. Wound Care: A Collaborative Practice Manual. Lip-pincott Williams & Wilkins, 2007.
  66. Tools for wound healing. URL: https://vn98.wordpress.com/wp-content/uploads/2017/09/chapter-13.pdf
  67. Sussman C., Swanson G. Utility of the Sussman Wound Healing Tool in predicting wound healing outcomes in physical therapy. Adv Wound Care. 1997; 10 (5): 74–7.
  68. Sanada H., Moriguchi T., Miyachi Y. et al. Reliability and validity of DESIGN, a tool that classifies pressure ulcer severity and monitors healing. J Wound Care. 2004; 13 (1): 13–8. doi: 10.12968/jowc.2004.13.1.26564
  69. Matsui Y., Furue M., Sanada H. et al. Development of the DESIGN-R with an observational study: an absolute evaluation tool for monitoring pressure ulcer wound healing. Wound Repair Regen. 2011; 19 (3): 309–15. doi: 10.1111/j.1524-475X.2011.00674.x
  70. Iizaka S., Sanada H., Matsui Y. et al. Predictive validity of weekly monitoring of wound status using DESIGN-R score change for pressure ulcer healing: a multicenter prospective cohort study. Wound Repair Regen. 2012; 20 (4): 473–81. doi: 10.1111/j.1524-475X.2012.00778.x
  71. van Lis M.S., van Asbeck F.W., Post M.W. Monitoring healing of pressure ulcers: a review of assessment instruments for use in the spinal cord unit. Spinal Cord. 2010; 48 (2): 92–9. doi: 10.1038/sc.2009.146
  72. Young D.L., Estocado N., Feng D. et al. The Development and Preliminary Validity Testing of the Healing Progression Rate Tool. Ostomy Wound Manage. 2017; 63 (8): 32–44. doi: 10.25270/owm.2017.09.3244

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