Modern approaches to rabies treatment: problems, research and new perspectives

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Abstract

The article analyzes scientific research on the treatment and prevention of rabies. The role of modern approaches to rabies treatment, international experience and recommendations, and new experimental strategies, including immunotherapy using interferon inducers, is shown using the example of the domestic Amphievovir dietary supplement, positioned as a potential treatment for viral infections, including rabies. Amphievovir is intended for topical and sublingual use, which ensures the gradual entry of the inducer into the body and a predominantly local effect, which increases the safety and convenience of use for patients. Data from domestic studies demonstrate that Amphievovir has successfully passed preclinical safety tests and has pronounced antiviral activity of a wide range. It is important to continue multicenter research on rabies therapy, possibly combining the efforts of virologists, clinicians and pharmacologists from different countries.

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About the authors

T. V. Potupchik

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia

Author for correspondence.
Email: potupchik_tatyana@mail.ru
ORCID iD: 0000-0003-1133-4447
SPIN-code: 8353-3513

Candidate of Medical Sciences

Russian Federation, Krasnoyarsk

S. V. Generalov

Russian Anti-Plague Research Institute «Microbe» of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Email: potupchik_tatyana@mail.ru
ORCID iD: 0000-0003-1461-5383
SPIN-code: 4130-2475

Candidate of Biological Sciences; Associate

Russian Federation, Saratov

M. M. Khabibulina

Ural State Medical University, Ministry of Health of Russia

Email: potupchik_tatyana@mail.ru
ORCID iD: 0000-0002-3240-1357
SPIN-code: 3456-9089

Associate Professor, Candidate of Medical Sciences

Russian Federation, Yekaterinburg

A. A. Spitsyn

LLC «SPA Evolution of Nature»

Email: potupchik_tatyana@mail.ru
ORCID iD: 0009-0005-4900-826X
Russian Federation, Novosibirsk

E. M. Shenderovich

N.F. Gamaleya Research Institute of Epidemiology and Microbiology, Ministry of Health of Russia

Email: potupchik_tatyana@mail.ru
ORCID iD: 0009-0003-3382-1411
Russian Federation, Moscow

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