Investigation of the product of deep enzymatic processing of brown seaweed as a topical cosmetic agent

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Abstract

Objective. To study the effect of a topical cosmetic product obtained by deep enzymatic processing of brown seaweed on the skin of the face and neck, as well as the hair growth zone.

Materials and methods. Sixty women (30 – main group, 30 – control group) took part in the study. Clinical, biochemical and morphological parameters of the facial skin and scalp before and after a 28-day course were evaluated. The list of techniques - non-invasive diagnostics (transepidermal moisture loss – TEWL, hydration level, pH, skin temperature balance), photo-documentation, spectral-confocal microscopy, immunohistochemistry of proliferation (Ki-67) and inflammation markers (CD33) in skin biopsy specimens, phototrichogram for hair growth analysis.

Results. As a result of the study the data indicating a reliable improvement of the skin condition of the face and neck against the background of application of a topical cosmetic based on the product of deep enzymatic processing of brown seaweed were obtained, which is caused by a decrease in transepidermal water loss, normalization of elasticity and hydration, increased proliferation of epidermal cells with simultaneous reduction of signs of chronic inflammation in the dermis. In the scalp there was an improvement of hair growth indicators: hair density and the proportion of hair follicles in the active phase (anagen) increased, while in the control group the indicators remained without significant dynamics.

Conclusion. The obtained data indicate a pronounced positive effect of the new product on skin and hair condition, which is attributed to the unique composition of bioactive molecules formed as a result of enzymatic processing of carbohydrate fraction of brown seaweed.

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About the authors

A. A. Khitrov

Research and Production Association «Biomedical Innovative Technologies»

Email: dgarmonov@npobit.com
ORCID iD: 0009-0004-1599-3209
SPIN-code: 6570-3526
Russian Federation, Tver region, Mednoye

D. A. Garmonov

Research and Production Association «Biomedical Innovative Technologies»

Author for correspondence.
Email: dgarmonov@npobit.com
ORCID iD: 0009-0009-2696-4880
SPIN-code: 2491-4032
Russian Federation, Tver region, Mednoye

O. 2 S. Korneeva

Voronezh State University of Engineering Technologies

Email: dgarmonov@npobit.com
ORCID iD: 0000-0002-2863-0771
SPIN-code: 3616-5977

Professor, Biol.D

Russian Federation, Voronezh

V. V. Dubensky

Tver State Medical University, Ministry of Health of Russia

Email: dgarmonov@npobit.com
ORCID iD: 0000-0002-5583-928X
SPIN-code: 6044-8507

Associate Professor, Candidate of Medical Sciences

Russian Federation, Tver

A. A. Garmonov

Medical center «Delomedika»

Email: dgarmonov@npobit.com
ORCID iD: 0009-0000-4749-4560
SPIN-code: 3291-0312

Candidate of Medical Sciences

Russian Federation, Lobnya

References

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2. Fig. 1. Transepidermal water loss in the study groups

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3. Fig. 2. Immunohistochemical markers of proliferation and inflammation in the skin in the study groups

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4. Fig. 3. Condition of the scalp in the study groups: a – anagen hair; б – hair density

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