Vol 32, No 3 (2021)

The paper is devoted to the problems of examining the association between disease and occupation in the novel coronavirus infection (COVID-19) in healthcare workers. It considers the main regulatory framework currently existing in the Russian Federation on the problems of examining the association between disease and occupation, which is used to when examining COVID-19 in healthcare workers, as well as the practice of examination according to the data of a regional center for occupational diseases.

The literature review provides information about the principles of radical pathogenetic treatment for hemorrhoid disease (HD), the emergence and further development of donor techniques that have served as the basis for developing the hemorrhoidal artery ligation and rectoanal (HAL-RAR) technology; and analyzes the reasons for its effectiveness due to the combination of two different approaches that have evolved independently of one another until a certain moment. The combination of these techniques has been incentive to a technological breakthrough in the treatment of HD and to the better quality of life in patients after surgical treatment. HAL-RAR has proven to be a highly effective and safe technique for the surgical treatment of HD. The relatively rare failures that occur after the HAL-RAR technology and lead to the need for resection procedures in the future do not reduce its popularity. One of the main advantages of this technology is the simplicity of its technical execution and minimal requirements for the skill and experience of the operator. Another important feature may be considered to be the ability to adapt the HAL-RAR technology for use in both outpatient settings and day hospitals without the need for long-term medical observation of patients.

The paper presents the ways to optimally increase the reserve capacities of the body of a human being located in the areas with unfavorable climatic and working conditions, by using short peptides.

Overactive bladder (OAB) and urinary incontinence (UI) have high prevalence in both genders after the age of 40 years. Urgency is the leading OAB symptom negatively impacted on patient quality of life. Antimuscarinic therapy is the primary of OAB and UI treatment. Solifenacin due to high-selectivity relieves OAB symptoms while good tolerability including patients with cardio-vascular comorbidity and seniors and improves quality of life. Management of women in postmenopause and men with benign prostatic hyperplasia needs complex treatment approach. Generics improves therapy affordable and treatment adherence.

The article presents the clinical, anamnesis and prognostic significance of a complex perinatal assessment in a comparative analysis of the tactics of respiratory therapy in children with extremely low body weight (ELBW) in the intensive care unit of newborns (NICU). Perinatal (maternal and neonatal) risk factors and the degree of progression of intraventricular hemorrhage (IVN) in the early neonatal period were studied based on the study of modern domestic and foreign scientific studies and our own clinical observation data in 2 children with EBMT. In a comparative analysis of cardiorespiratory predictors, clinical picture of varying severity of respiratory failure and gestational morphometry, a differentiated approach to the choice of the optimal tactics of initial respiratory therapy in children with EBMT in an ICU in the early neonatal period was considered.

The paper presents the results of Holter ECG monitoring in 126 women with Stages I-II hypertension and noncoronarogenous cardialgia-type cardiac pain syndrome in the late fertile period with different levels of estradiol and follicle-stimulating hormone (FSH) according to the cardiac and extracardiac comorbidities in an outpatient setting. The risk of silent myocardial ischemia (SMI) is higher in hypertensive women with a history of chronic ovarian diseases, medical abortions, bad habits (smoking), and a genetic predisposition to hypertension. SMI occurs in 18.8% of the women with hypertension and cardialgia in the late fertile period with chronic reproductive system diseases, a family gynecologic history, premenstrual syndrome, and, possibly, as a consequence, altered estradiol and FSH levels.

Objective: to present the experience with combined recombinant interferon alpha-2b medications for the topical treatment of seasonal allergic rhinitis (AR) exacerbations. Materials and Methods: The study design was a simple prospective one. This study was conducted on the basis of the Department of Allergology and Immunology of the Omsk City Polyclinic No. 12. The study involved 100 patients who had consulted an allergist about allergic rhinitis (AR) exacerbations - men and women aged 18 to 55 years, mean age (Me 25;75) - 33.0 (28;47) years. There were two consecutive groups of patients: those with acute non-severe seasonal AR and those with acute moderate-to-severe seasonal AR. A group of patients with non-severe AR (group 1; n=50) used the combined interferon-based medication Allergoferon (gel) to treat the disease in the acute phase. A group of patients with moderate-to-severe AR (group 2; n=50) used Allergoferon beta (nasal and eye drops) for the disease treatment in the acute phase. The patients’ conditions were assessed during follow-up examinations on the 7th (visit 2) and 14h (visit 3) days of treatment. Subjective symptoms were evaluated by the questionnaire-based method. This helped to determine the treatment effectiveness as well as the presence and severity of side effects. The effectiveness was assessed based on the reduction in the severity of local and general reactions. Tolerability of the medications was determined according to the patients subjective assessment. Results: Control examinations of patients in both groups were conducted on the 7th and 14th days of treatment. On the 7th day of treatment the patients in both groups reported improvement: in the group 1 (patients with non-severe AR) symptoms resolution was noted by 50% of patients, in the group 2 (patients with moderate-to-severe AR) - by 80%. In the group 1 some patients had nasal congestion (50%), eyelids itching (50%), nasal discharge (40%) and sneezing (50%), but the severity of these symptoms (in points) significantly decreased. In the group 2 some patients had the following symptoms: nasal congestion (38%), nasal discharge (31%), sneezing (20%) and eyelids itching (25%), but they reported much less severe symptoms. Patients in both groups had a significant reduction in the severity of all symptoms (nasal congestion, eyelids itching, nasal discharge, sneezing). No side effects were reported. Conclusion: During our study it was noted that both examined interferon-based medications (Allergoferon and Allergoferon Beta) allowed us to achieve a relief of subjective and objective symptoms of AR. In both groups a good tolerability of these medications was noted, no side effects and no cases of withdrawal or refusal were observed.

In the article, the authors describe the experience of using in clinical practice the oral fibrinolytic in the conservative treatment of acute combined thrombosis of the saphenous and deep veins of the lower extremities against the background of the use of anticoagulants, flavonoid drugs, elastic compression of the lower extremities. The results of using the proposed treatment regimen in relation to the therapy of this pathology without prescribing a thrombolytic agent after 1, 3 and 6 months of treatment at the outpatient stage are presented. The dynamics of recanalization of the venous bed and the dynamics of reduction of clinical manifestations of the disease are analyzed. The safety of the treatment is also assessed.