Vol 27, No 1 (2016)

The paper considers an association between poor perinatal factors and risk for disorders in the emotional-volitional sphere and behavior. It discusses whether these disorders are affected by a pregnant woman’s hormonal changes or bad habits, a number of medications, intrauterine infections, or alimentary deficit. There are data on an association of risk for the above disorders with a baby’s cesarean birth, prematurity, and/or low birth weight, birth hypoxia or trauma, and maternal postpartum depression. The possible mechanisms underlying the found associations are discussed. Preventive approaches are outlined.

Comparative analysis of different treatment regimens for primary knee osteoarthritis demonstrated the efficacy of the combined intraarticular administration of heterogeneous biopolymer hydrogel and a hyaluronic acid preparation, which was best in terms of all indicators. The duration of the follow-up was 12 months.

Hepatoprotective drugs are in considerable use in obstetric practice in the Russian Federation. Questioning of physicians in the survey “Epidemiology of drug use in pregnant women" has shown that ursodeoxycholic acid (UDCA), the only hepatoprotector that has an evidence basis for the safety of a fetus and efficacy in treating cholestatic diseases, is used relatively rarely (in 27.0% of cases) and, on the contrary, essential phospholipids and artichoke (Cynara scolymus) extract are in common use (56.6% and 62.3%, respectively). The timely use of UDCA in a daily dose of 15 mg/kg in pregnant women with intrahepatic cholestasis makes it possible to alleviate clinical symptoms and to reduce the frequency of obstetric and perinatal complications.

The administration of Erespal to treat acute bronchitis in adults is shown to be accompanied by shorter alleviation of all symptoms of the disease, by a more dynamic regression of expectoration; by a reduction in the preservation of fever and intoxication syndromes, by good therapy tolerability and high patient compliance. The use of Erespal in the therapy of acute bronchitis in adults contributes to a reduction in the need for additional use of antibacterial drugs.

In children with heart diseases accompanied by chronic heart disease (CHD) the activity of major energy metabolic enzymes (succinate dehydrogenase and glycerol-3-phosphate dehydrogenase) was found to be decreased, and the significance of these changes corresponded to the severity of clinical manifestations of CHD. The original drug Eltacin consisting of 3 nonessential amino acids: L-glutamic acid, glycine, and L-cystine (70 mg of each substance) was used. Clinical and cytochemical techniques were employed to evaluate therapeutic effectiveness from mitochondrial dehydrogenase activity in peripheral blood lymphocytes. The drug was found to positively affect the activity of mitochondrial enzymes. It was shown that for children with CHD the long-term Eltacin intake is necessary to have a lasting clinical effect.

The paper considers the efficiency of treatment using the osteoprotector Osteo-Vit D3 in children with recurrent fractures and low bone mineral density.

The paper describes a case of a reproductive-aged patient with aggressive endometrioid disease, as well as extragenital disease, in which the patient is to be not only thoroughly carefully, but also to further undergo surgery.

The biocomplex AndroDoz® used to treat impaired male fertility contains all necessary trace elements and vitamins involved in spermatogenesis. Clinical trials have indicated that the drug improves the qualitative and quantitative characteristics of sperm, increases its concentration and ejaculate volume. The efficiency and safety of AndroDoz in andrological practice are considered and commented.

Twelve-week use of ivabradine in the combination therapy of patients with stable angina concurrent with diastolic dysfunction and an ejection fraction of >50% improves left ventricular diastolic function and achieves target heart rate.

The impact of combined therapy with amlodipine and ramipril on the structural and functional status of the myocardium and the diastolic function of the left ventricle was evaluated in hypertensive patients under the conditions of the Far North.

The paper comparatively analyzes daily heart rhythm variability indicators and assesses the risk of recurrent atrial fibrillations in patients with coronary heart diseases and hypertension.

The clinical example is used to discuss the key problems of differential diagnosis of dyspnea in outpatient settings and the practical actions of a polyclinic physician. Emphasis is placed on the need for a comprehensive, multidisciplinary approach to making a diagnosis and determining a treatment option in patients with dyspnea.