Vol 29, No 11 (2018)

The paper gives data on the prevalence of tuberculosis concurrent with HIV infection, on the clinical, radiological, and laboratory manifestations of tuberculosis, and on the efficiency of its therapy.

The paper gives data on the use of nootropic drugs that may be used in the combination therapy of chronic alcoholism.

The paper considers the problem of enhancing the efficiency of surgical treatment in patients with major complications of cochlear implantation (CI). The most common cause of major complications of CI is a technical failure with implants.

Surgical treatment for drug-resistant bilateral pulmonary tuberculosis is a difficult task due to the fact that destructive processes are morphologically dominant in drug-resistant pulmonary tuberculosis and it is difficult to achieve stabilization of the process through traditional drug therapy. A comprehensive approach with innovative collapse surgical procedures and intravenous laser blood irradiation could attain clinical recovery and complete social adaptation in a female patient with complicated bilateral fibrous-cavernous tuberculosis with multidrug resistance of the pathogen.

Hodgkin’s disease is a rare blood disease characterized by clonal proliferation of B cells in the germinal centers of lymph nodes; it is a malignant tumor of lymphoid tissue.

To prevent cerebrovascular diseases is the most effective way of solving the problem of brain vascular lesions. Incorporation of neurometabolic drugs in their combination therapy can improve the outcome of the already developed disease. The clinical effects of L-carnitine (Elkar) are considered in patients with acute and chronic cerebral ischemia. Its maximum effect is noted when non-drug treatment and adequate drug therapy are used at the same time.

In order to clarify the mechanism of analgesic action of topiramate in the prophylactic treatment of chronic migraine (CM), the time course of changes in the clinical indicators of the severity of cephalgia and in cortical excitability by transcranial magnetic stimulation (TMS) was studied in 42 patients with CM. After 3 months of treatment with topiramate (100 mg/day), along with a significant decrease in the frequency of headache, there was a significant increase in the thresholds of evoked motor responses and in the threshold for phosphenesis in the absence of changes in the silent period duration. The results of the investigation made it possible to clarify the central effects of topiramate in CM in reducing visual and motor cortical neuronal excitability in the presence of stability of the cortical inhibition mechanisms estimated by TMS.

The smoking history of 325 adults with disability due to various diseases was studied. The relationship of smoking to the risk of certain groups of diseases was established to be dose-dependent.

Clinical parameters were analyzed in patients with chronic obstructive kidney disease (COPD) and osteoarthritis who received combined therapy (with low-intensity laser radiation and chondroitin sulfate). This combined therapy for not only joint pain syndrome, but also the symptoms of COPD is shown to be effective.