BISOPROLOL IN PATIENTS WITH CORONARY HEART DISEASE, ARTERIAL HYPERTENSI0N, AND CONCOMITANT PSORIASIS


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Abstract

Beta-blockers (BB) are known to be effectively reduce mortality and the risk of myocardial infarction, stroke, and other cardiovascular events in patients with coronary heart disease (CHD), chronic heart failure, arterial hypertension (AH), and arrhythmias. However, the use of nonselective and secondary generation relatively selectivite BB can be complicated by psoriasis exacerbation or psoriasiform erythema developement, an adverse reaction generally related to the undesirable β 2-adrenoreceptor blockade. One hundred and two hypertensive patients with severe exacerbated psoriasis and CHD were enrolled in the trial aimed to asses efficacy and safety of highly selective b1-blockerbisoprolol (Bidop, Gedeon Richter). The study results showed that bisoprolol while significantly reduced number of anginal attacks and lowered blood pressure, did not affect the psoriasis course and symptom improvement.

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About the authors

A. Shevchenko

Russian National Research Medical University, Moscow

Email: clin_cardio@yahoo.com

E. Dvoryankova

Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Moscow

Email: clin_cardio@yahoo.com

О. Shevchenko

Russian National Research Medical University, Moscow

Email: clin_cardio@yahoo.com

Yu. Shilova

Dermatovenereology Dispensary Fifteen, Moscow

Email: clin_cardio@yahoo.com

L. Ginzburg

Regional Hospital One, Lyubertsy

Email: clin_cardio@yahoo.com

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