SSHIFTS IN THE HEMOSTATIC SYSTEM ARE A COMPONENT OF SYSTEMIC INFLAMMATORY RESPONSE SYNDROME IN PULMONARY TUBERCULOSIS

Patients with pulmonary tuberculosis have been found to have significant systemic inflammatory response syndrome (SIRS) and its associated hypercoagulation shift in the hemostatic system. In the cellular component, it appears as thrombocytosis and increased platelet responsiveness. In the plasma component, there are increasing concentrations of thrombogenic proteins in inadequate fibrinolysis. The degree of hypercoagulation syndrome is directly related to the severity of SIRS, but usually fails to result in multiple organ dysfunction and/or hemorrhage due to consumption coagulopathy.

hemostasis, systemic inflammatory response syndrome, tuberculosis, acute phase reactants