PROGNOSTIC VALUE OF LIPID METABOLISM MARKERS IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Out of 133 patients diagnosed with ST-segment elevation myocardial infarction (MI), 66 were found to have early MI complications (acute heart failure, early postinfarction angina pectoris, recurrent MI, life-threatening cardiac rhythm and conduction disturbances) during hospitalization. During a year, 38 patients were fixed to have unfavorable disease outcomes, such as progressive angina pectoris, decompensated heart failure, and recurrent MI. Only 3 out of all the lipid profile parameters determined in the hospital period of MI, such as the levels of free fatty acids, oxidized and modified low-density lipoproteins and their antibodies, were established to be of prognostic value in patients with both early and late outcomes of MI.

Full Text

Restricted Access

About the authors

Yu. Dyleva

Research Institute for Complex Problems of Cardiovascular Diseases, Siberian Branch, Russian Academy of Medical Sciences

Email: dyleva87yandex.ru

O. Gruzdeva

Research Institute for Complex Problems of Cardiovascular Diseases, Siberian Branch, Russian Academy of Medical Sciences

Candidate of Medical Sciences

V. Karetnikova

Research Institute for Complex Problems of Cardiovascular Diseases, Siberian Branch, Russian Academy of Medical Sciences

References

  1. Васина Л.В. Механизмы дисфункции эндотелия при остром коронарном синдроме. Автореф. дис.. д-ра мед. наук. СПб, 2008.
  2. Камышова Т.В., Небиеридзе Д.В., Константинов В.В. и др. Связь различных факторов риска с состоянием эндотелиальной функции // Кардиоваск. тер. и профилакт. - 2003; 2 (2): 23-7.
  3. Aras O., Dilsizian V. Targeting ischemic memory // Cur. Opin. Biotechnol. -2007; 18: 46-51.
  4. Collet J., Montalescot G., Vicaut E. et al. Acute release of plasminogen activator inhibitor-1 in ST-segment elevation myocardial infarction predicts mortality // Circulation. - 2003; 108 (4): 391-4.
  5. Hajer G., van Haeften T., Visseren F. Adipose tissue dysfunction in obesity, diabetes, and vascular diseases // Eur. Heart. J. - 2008; 29: 2959-71.
  6. Khot U., Khot M., Bajzer C. et al. Prevalence of conventional risk factors in patients with coronary heart disease // JAMA. - 2003; 290 (7): 898-904.
  7. Laczik R., Szodoray P., Veres K. et al. Assessment of IgG antibodies to oxidized LDL in patients with acute coronary syndrome // Lupus. - 2011; 20: 730-5.
  8. Lapointe A., Piché M., Weisnagel S., et al. Associations between circulating free fatty acids, visceral adipose tissue accumulation, and insulin sensitivity in postmenopausal women // Metabolism. - 2009; 58: 180-5.
  9. Madamanchi N., Runge M. Mitochondrial Dysfunction in Atherosclerosis // Circ. Res. - 2007; 100: 460-73.
  10. Meisinger C., Baumert J., Khuseyinova N. et al. Plasma oxidized low-density lipoprotein, a strong predictor for acute coronary heart disease events in apparently healthy, middle-aged men from the general population // Circulation. -2005; 112: 651-7.
  11. Opie L., Knuuti J. The Adrenergic-Fatty Acid Load in Heart Failure // J. Am. Coll. Cardiol. - 2009; 54: 1637-46.
  12. Schonfeld P., Wojtczak L. Fatty acids as modulators of the cellular production of reactive oxygen species // Free Radic. Biol. Med. - 2008; 45 (3): 231-41.
  13. Shoenfeld Y., Wu R., Linda D. Dearing and Eiji Matsuura. Are Anti-Oxidized Low-Density Lipoprotein Antibodies Pathogenic or Protective? // Circulation. -2004; 110: 2552-8.
  14. Tsimikas S. Oxidative biomarkers in the diagnosis and prognosis of cardiovascular disease // Am. J. Cardiol. - 2006; 98: 9-17.
  15. Witteles R., Fowler M. Insulin-resistant cardiomyopathy clinical evidence, mechanisms, and treatment options // J. Am. Coll. Cardiol. - 2008; 51: 93-102.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2013 Russkiy Vrach Publishing House

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies