FEVER PATHOGENESIS AND PATHOGENETIC JUSTIFY THE CHOICE OF ANTIPYRETICS
- Authors: Delyagln V.1
-
Affiliations:
- Federal Scientific and Clinical Centre of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev
- Issue: Vol 27, No 12 (2016)
- Pages: 67-71
- Section: Articles
- URL: https://journals.eco-vector.com/0236-3054/article/view/116833
- ID: 116833
Cite item
Abstract
There are a number of reasons fever. But the mechanism of its occurrence there is one effect of exogenous and endogenous pyrogens. Pyrogens disrupts the thermoregulatory center. Pyrogenic are pro-inflammatory agents. Fever can cause deep, sometimes irreversible changes in many organs and systems, which requires the active reduction of hyperthermia. As the choice of the drug is recommended Nurofen.
Keywords
Full Text
![Restricted Access](https://journals.eco-vector.com/lib/pkp/templates/images/icons/text_lock.png)
About the authors
V. Delyagln
Federal Scientific and Clinical Centre of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev
Email: delyagin-doktor@yandex.ru
Professor MD Moscow
References
- Sajadi M., Mackowiak Ph. Temperature Regulation and the Pathogenesis of Fever. In: Bennet J., Dolin R., Blaser B. (Ed.) Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 8th Ed. / Saunders, 2015; 708-20e4.
- Majno G. The Healing Hand: Man and Wound in the Ancient World Cambridge: Harvard University Press, 1991; 571 p.
- Siegel R. (Ed.) Galen’s System of Physiology and Medicine / New York: Karger; 1968; 420 p.
- Sajadi M., Bonabi R., Sajadi M. et al. Akhawayni and the first fever curve // Clin. Infect. Dis. - 2012; 55 (7): 976-80.
- Mackowiak P., Worden G. Carl Reinhold August Wunderlich and the evolution of clinical thermometry // Clin. Infect. Dis. - 1994; 18 (3): 458-67.
- Commission for Thermal Physiology of the International Union of Physiological Sciences. Glossary of terms for thermal physiology (3rd Ed.) // Jpn. J. Physiol. - 2001; 51 (2): 245-80.
- Делягин В.М. Лихорадка. Многообразие причин и сложность решения // Consilium Medicum. Педиатрия. - 2011; 4: 49-52.
- Делягин В.М., Мальцев В.И., Румянцев А.Г. Лекции по клинической диагностике внутренних болезней / Киев: Морион, 2007; 664 с.
- Nakamura K., Morrison S. A thermosensory pathway mediating heat-defense responses // Proc. Natl. Acad. Sci. USA. - 2010; 107 (19): 8848-53.
- Tan C., Cooke E., Leib D. et al. Warm-sensitive neurons that control body temperature // Cell. - 2016; 167 (1): 47-59.
- McAllen R., Tanaka M., Ootsuka Y. et al. Multiple thermoregulatory effectors with independent central controls // Eur. J. Appl. Physiol. - 2010; 109 (1): 27-33.
- Walter E., Sameer H.-J., Caratallo M. et al. The pathophysiological basis of fever // Crit. Care. - 2016, 20: 200. Published online 2016 Jul 14. doi:10.1186/ s13054-016-1375-5.
- Dinarello C. Infection, fever, and exogenous and endogenous pyrogens: some concepts have changed // J. Endotoxin. Res. - 2004; 10 (4): 201-22.
- Kroufol Z. Cytokines and mental health / Springer, 2003; 428 p.
- Chase K., Cone L., Rosen C. et al. The value of interleukin 6 as a peripheral diagnostic marker in schizophrenia // BMC Psychiatry. - 2016; doi: 10.1186/ s12888-016-0866-x.
- Vlad M., Ionescu N., Ispas A. et al. Morphological changes during acute experimental short-term hyperthermia // Rom. J. Morphol. Embryol. - 2010; 51 (4): 739-44.
- Argaud L., Ferry T., Le Q. et al. Short- and long-term outcomes of heatstroke following the 2003 heat wave in Lyon // France Arch. Intern. Med. - 2007; 167 (20): 2177-83.
- Etulain J., Lapponi M., Patrucchi S. et al. Hyperthermia inhibits platelet hemostatic functions and selectively regulates the release of alpha-granule proteins // J. Thromb. Haemost. - 2011; 9 (8): 1562-71.
- Pease S., Bouadma L., Kermarrec N. et al. Early organ dysfunction course, cooling time and outcome in classic heatstroke // Intens Care Med. - 2009; 35 (8): 1454-8.
- Badoer E. Role of the hypothalamic PVN in the regulation of renal sympathetic nerve activity and blood flow during hyperthermia and in heart failure // Am. J. Physiol. Renal. Physiol. - 2010; 298 (4): F839-46.
- Hall D., Buettner G., Oberley L. et al. Mechanisms of circulatory and intestinal barrier dysfunction during whole body hyperthermia // Am. J. Physiol. Heart Circ. Physiol. - 2001; 280: H509-21.
- Carleton B., Smith M., Gelin M. et al. Paediatric adverse drug reaction reporting: understanding and future directions // Can. J. Clin. Pharmacol. - 2007; 14 (1): 45-57.
- Yewale V., Dharmapalan D. Promoting appropriate use of drugs in children // Int. J. Pediatr. - 2012; 2012: 906570.
- Ушкалова Е.А. Выбор оптимального жаропонижающего средства в педиатрической практике // Лечащий врач. - 2012; 8: 66-9.
- Hay A., Costelloe C., Redmond N. et al. Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): Randomised controlled trial // BMJ. - 2008; 337 (a1302): 1-9.
- Pelen F., Verriere F. Treatment of Fever: Monotherapy with Ibuprofen. Ibuprofen Paediatric Suspension Containing 100 mg per 5 ml. Multi Centre Acceptability Study Conducted in Hospital // Annales de Pediatrie. - 1998; 45 (10): 719-28.
- Yue Z., Jiang P., Sun H. и др. Association between an excess risk of acute kidney injury and concomitant use of ibuprofen and acetaminophen in children, retrospective analysis of a spontaneous reporting system // Eur. J. Clin. Pharmacol. - 2014; 70 (4): 479-82. doi: 10.1007/s00228-014-1643-8. Epub 2014 Jan 21.
- Vecchio M., Sundel E. Alternating Antipyretics: Is This an Alternative? // Pediatrics. - 2001; 108 (5): 1236-7.
- Lesko S., Mitchell A. An assessment of the safety of pediatric ibuprofen: a practitioner-based randomized clinical trial // JAMA. - 1995; 273 (12): 929-33.
- Баранов А.А., Таточенко В.К., Бакрадзе М.Д. Лихорадящий ребенок. Протоколы диагностики и лечения (сер. «Клинические рекомендации для педиатров»). Изд. 2-е испр. и дополн. / www.d22d.ru/load/42-1-0-1103 и www. d22d.ru/load/42-1-0-1104.
- Lieberthal A., Carroll A., Chonmaitree T. et al. Clinical Practice Guideline: The Diagnosis and Management of Acute Otitis Media // Pediatrics. - 2013; 131 (3): e964-e99.
- Vecchio M., Sundel E. Alternating Antipyretics: Is This an Alternative? // Pediatrics. - 2001; 108 (5): 1236-7.
- Chiappini E., Principi N., Longhi R. et al. Management of fever in children: summary of the Italian Pediatric Society guidelines // Clin. Ther. - 2009; 31 (8): 1826-43.
- Autret-Leca E. A general overview of the use of ibuprofen in paediatrics // Int. J. Clin. Pract. Suppl. - 2003; 135: 9-12.
- Pursell E. Treating fever in children: paracetamol or ibuprofen? // Br. J. Community Nurs. - 2002; 7 (6): 316-20.
- Pereira G., Dagostini J., Pizzol T. Alternating antipyretics in the treatment of fever in children: a systematic review of randomized clinical trials // J. Pediatr. (Rio J.). - 2012; 88 (4): 289-96.
- Mayoral C., Marino R., Rosenfeld W., Greensher J. Alternating antipyretics: is the alternative // Pediatrics. - 2000; 105 (5): 1009-12.
- Wong T., Stang A., Ganshorn H. et al. Cochrane in context: combined and alternating paracetamol and ibuprofen therapy for febrile children // Evid. Based Child Health. - 2014; 9 (3): 730-2.
- National Institute for Health and Care Excellence (NICE). CG160 Feverish illness in children. May 2013. Accessed 4th November 2013. Available at: http:// guidance.nice.org.uk/CG160.
Supplementary files
![](/img/style/loading.gif)