Hematological indicators as predictors of atrial fibrillation after cardiac surgery
- Authors: Tatarintseva Z.1,2, Kosmacheva E.1,2, Shyk A.2, Batchaeva A.2
-
Affiliations:
- Research Institute – Prof. S.V. Ochapovsky Territorial Clinical Hospital One
- Kuban State Medical University, Ministry of Health of Russia
- Issue: Vol 35, No 1 (2024)
- Pages: 15-18
- Section: For Diagnosis
- URL: https://journals.eco-vector.com/0236-3054/article/view/626817
- DOI: https://doi.org/10.29296/25877305-2024-01-03
- ID: 626817
Cite item
Abstract
Newly diagnosed postoperative atrial fibrillation (NDPAF) is one of the most common complications after cardiovascular surgery, provoking early and late complications, such as cardiovascular, thromboembolic complications, cerebral circulation disorders, prolonged hospital stay and repeated hospitalizations to the intensive care unit and hospital.
Objective. To identify biochemical and clinical predictors of NDPAF in patients who underwent open-heart surgery for any indication.
Materials and methods. The study included patients operated in the cardiac surgery department No.2 of the Research Institute – Prof. S.V. Ochapovsky Territorial Clinical Hospital One (Krasnodar) in the period from January 1, 2020 to January 1, 2021. During the analyzed period of time, open heart surgery was performed in 1503 patients, of whom 158 (10.5%) had NDPAF.
Results. Hematological/biochemical parameters include low levels of hemoglobin (<12.5 g/dl), hematocrit (<35%), erythrocytes (<4,2•1012/L), and high levels of lymphocytes (>3,0•109/L), bilirubin (20.5 mmol/L), creatinine (115 mmol/L), urea (8.3 mmol/L), aspartate aminotransferase (>35 U/L), alanine aminotransferase (>55 U/L), C-reactive protein (>5 mg/L) were associated with an increased frequency of NDPAF in single-factor analysis (p<0.05 for all comparisons).
Conclusion. Hematological indicators can predict the risk of atrial fibrillation before surgery. The study of risk factors for NDPAF will allow to effectively influence them, thereby preventing the possibility of arrhythmia and improving the prognosis for postoperative complications and survival.
Full Text
About the authors
Z. Tatarintseva
Research Institute – Prof. S.V. Ochapovsky Territorial Clinical Hospital One; Kuban State Medical University, Ministry of Health of Russia
Author for correspondence.
Email: z.tatarintseva@list.ru
ORCID iD: 0000-0002-3868-8061
Candidate of Medical Sciences
Russian Federation, Krasnodar; KrasnodarE. Kosmacheva
Research Institute – Prof. S.V. Ochapovsky Territorial Clinical Hospital One; Kuban State Medical University, Ministry of Health of Russia
Email: z.tatarintseva@list.ru
ORCID iD: 0000-0001-5690-2482
Professor, MD
Russian Federation, Krasnodar; KrasnodarA. Shyk
Kuban State Medical University, Ministry of Health of Russia
Email: z.tatarintseva@list.ru
Russian Federation, Krasnodar
A. Batchaeva
Kuban State Medical University, Ministry of Health of Russia
Email: z.tatarintseva@list.ru
Russian Federation, Krasnodar
References
- Luo W., Huaibin W., Wenjun Z. et al. Predictors of postoperative atrial fibrillation after isolated on-pump coronary artery bypass grafting in patients ≥60 years old. Heart Surg Forum. 2017; 20 (1): E038–E042. doi: 10.1532/hsf.1583
- Mirhosseini S.J., Forouzannia S.K., Sayegh A.H. et al. Effect of prophylactic low dose of methylprednisolone on postoperative new atrial fibrillation and early complications in patients with severe LV dysfunction undergoing elective off-pump coronary artery bypass surgery. Acta Med Iran. 2011; 49 (5): 288–92.
- Sabashnikov A., Weymann A., Haldar S. et al. Position of totally thoracoscopic surgical ablation in the treatment of atrial fibrillation: an alternative method of conduction testing. Med Sci Monit Basic Res. 2015; 21: 76–80. doi: 10.12659/MSMBR.894239
- Li T., Sun Z.L., Xie Q.Y. Meta-analysis identifies serum C-reactive protein as an indicator of atrial fibrillation risk after coronary artery bypass graft. Am J Ther. 2016; 23 (6): e1586–e1596. doi: 10.1097/MJT.0000000000000255
- Bessissow A., Khan J., Devereaux P.J. et al. Postoperative atrial fibrillation in non-cardiac and cardiac surgery: an overview. J Thromb Haemost. 2015; 13: 304–12. doi: 10.1111/jth.12974
- Nair S.G. Atrial fibrillation after cardiac surgery. Ann Card Anaesth. 2010; 13 (3): 196–205. doi: 10.4103/0971-9784.69047
- Danelich I.M., Lose J.M., Wright S.S. et al. Practical management of postoperative atrial fibrillation after noncardiac surgery. J Am Coll Surg. 2014; 219 (4): 831–41. doi: 10.1016/j.jamcollsurg.2014.02.038
- Dobrev D., Aguilar M., Heijman J. et al. Postoperative atrial fibrillation: mechanisms, manifestations and management. Nat Rev Cardiol. 2019; 16 (7): 417–36. doi: 10.1038/s41569-019-0166-5
- Turagam M.K., Mirza M., Werner P.H. et al. Circulating biomarkers predictive of postoperative atrial fibrillation. Cardiol Rev. 2016; 24 (2): 76–87. doi: 10.1097/CRD.0000000000000059
- Guan B., Li X., Xue W. et al. Blood lipid profiles and risk of atrial fibrillation: a systematic review and meta-analysis of cohort studies. J Clin Lipidol. 2020; 14 (1): 133–42. doi: 10.1016/j.jacl.2019.12.002
- Li X.Y., Hou H.T., Chen H.X. et al. Preoperative plasma biomarkers associated with atrial fibrillation after coronary artery bypass surgery. J Thorac Cardiovasc Surg. 2021; 162 (3): 851–863.e3. doi: 10.1016/j.jtcvs.2020.01.079
- Gorczyca I., Michta K., Pietrzyk E. et al. Predictors of post-operative atrial fibrillation in patients undergoing isolated coronary artery bypass grafting. Kardiol Pol. 2018; 76 (1): 195–201. doi: 10.5603/KP.a2017.0203
- Cerit L., Kemal H., Gulsen K. et al. Relationship between Vitamin D and the development of atrial fibrillation after on-pump coronary artery bypass graft surgery. Cardiovasc J Afr. 2017; 2: 104–7. doi: 10.5830/CVJA-2016-064
- Chua S.K., Shyu K.G., Lu M.J. et al. Association between renal function, diastolic dysfunction, and postoperative atrial fibrillation following cardiac surgery. Circ J. 2013; 77 (9): 2303–10. doi: 10.1253/circj.CJ-13-0273
- January C.T., Wann L.S., Calkins H. et al. 2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol. 2019; 74 (1): 104–32 [Erratum in: J Am Coll Cardiol. 2019; 74 (4): 599]. doi: 10.1016/j.jacc.2019.01.011
- Kinoshita T., Asai T., Takashima N. et al. Preoperative C-reactive protein and atrial fibrillation after off-pump coronary bypass surgery. Eur J Cardiothorac Surg. 2011; 40 (6): 1298–303. doi: 10.1016/j.ejcts.2011.03.027
- Şaşkin H., Düzyol Ç., Aksoy R. et al. Do preoperative C-reactive protein and mean platelet volume levels predict development of postoperative atrial fibrillation in patients undergoing isolated coronary artery bypass grafting? Postepy Kardiol Interwencyjnej. 2016; 12 (2): 156–63. doi: 10.5114/aic.2016.59366
- Weymann A., Ali-Hasan-Al-Saegh S., Sabashnikov A. et al. Prediction of new-onset and recurrent atrial fibrillation by complete blood count tests: a comprehensive systematic review with meta-analysis. Med Sci Monit Basic Res. 2017; 12 (23): 179–222. doi: 10.12659/msmbr.903320
- Abbaszadeh S., Shafiee A., Bina P. et al. Preoperative hemoglobin A1c and the occurrence of atrial fibrillation following on-pump coronary artery bypass surgery in type-2 diabetic patients. Crit Pathw Cardiol. 2017; 16 (1): 37–41. doi: 10.1097/HPC.0000000000000103
- Zhao H., Liu M., Chen Z. et al. Dose-response analysis between hemoglobin A1c and risk of atrial fibrillation in patients with and without known diabetes. PLoS One. 2020; 15 (2): e0227262. doi: 10.1371/journal.pone.0227262
- Demir M., Demir C., Uyan U. et al. The relationship between serum bilirubin concentration and atrial fibrillation. Cardiol Res. 2013; 4 (6): 186–91. doi: 10.4021/cr299w
- Sun D., Li W., Zheng W. et al. Direct bilirubin level is an independent risk factor for atrial fibrillation in thyrotoxic patients receiving radioactive iodine therapy. Nucl Med Commun. 2019; 40 (12): 1289–94. doi: 10.1097/MNM.0000000000001107
- Ali-Hassan-Sayegh S., Mirhosseini S.J., Haddad F. et al. Protective effects of corticosteroids in coronary artery bypass graft surgery alone or combined with valvular surgery: an updated and comprehensive meta-analysis and systematic review. Interact Cardiovasc Thorac Surg. 2015; 20 (6): 825–36. doi: 10.1093/icvts/ivv033
- Дедов Д., Эльгардт И., Масюков С. и др. Электрическое ремоделирование миокарда и прогноз у больных с фибрилляцией предсердий. Врач. 2015; 11: 77–9 [Dedov D., Elgardt I., Masyukov S. et al. Myocardial electrical remodelling and prognosis in patients with atrial fibrillation. Vrach. 2015; 11: 77–9 (In Russ.)].