Pathological anatomy of COVID-19
- Authors: Redko A.1, Bunga O.1
-
Affiliations:
- M.V. Lomonosov Moscow State University
- Issue: Vol 35, No 2 (2024)
- Pages: 59-63
- Section: From Practice
- URL: https://journals.eco-vector.com/0236-3054/article/view/632174
- DOI: https://doi.org/10.29296/25877305-2024-02-11
- ID: 632174
Cite item
Abstract
The paper provides a review of the literature on pathologoanatomical features of different organs affected by SARS-CoV-2 virus. Signs of necrosis and dystrophy, various circulatory disorders were mainly detected. Morphologic features are not specific for COVID-19; they can also be detected in other systemic infections and shock. This should be taken into account during the pathological autopsy. At the same time, some studies show a connection between SARS-CoV-2 and some diseases with an etiology that is not fully understood, so additional research is required.
Keywords
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About the authors
A. Redko
M.V. Lomonosov Moscow State University
Author for correspondence.
Email: redko.artyom@mail.ru
ORCID iD: 0009-0007-4887-8970
Russian Federation, Moscow
O. Bunga
M.V. Lomonosov Moscow State University
Email: redko.artyom@mail.ru
ORCID iD: 0009-0009-9345-0353
Russian Federation, Moscow
References
- Deshmukh V., Motwani R., Kumar A. et al. Histopathological observations in COVID-19: A systematic review. J Clin Pathol. 2021; 74 (2): 76–83. doi: 10.1136/jclinpath-2020-206995
- Hammoud H., Bendari A., Bendari T. et al. Histopathological Findings in COVID-19 Cases: A Systematic Review. Cureus. 2022; 14 (6): e25573. doi: 10.7759/cureus.25573
- Mondello C., Roccuzzo S., Malfa O. et al. Pathological Findings in COVID-19 as a Tool to Define SARS-CoV-2 Pathogenesis. A Systematic Review. Front Pharmacol. 2021; 12 :614586. doi: 10.3389/fphar.2021.614586
- Tabary M., Khanmohammadi S., Araghi F. et al. Pathologic features of COVID-19: A concise review. Pathol Res Pract. 2020; 216 (9): 153097. doi: 10.1016/j.prp.2020.153097
- Caramaschi S., Kapp M.E., Miller S.E. et al. Histopathological findings and clinicopathologic correlation in COVID-19: a systematic review. Mod Pathol. 2021; 34 (9): 1614–33. doi: 10.1038/s41379-021-00814-w
- Septimiu-Radu S., Gadela T., Gabriela D. et al. A Systematic Review of Lung Autopsy Findings in Elderly Patients after SARS-CoV-2 Infection. J Clin Med. 2023; 12 (5): 2070. doi: 10.3390/jcm12052070
- Satturwar S., Fowkes M., Farver C. et al. Postmortem Findings Associated with SARS-CoV-2: Systematic Review and Meta-analysis. Am J Surg Pathol. 2021; 45 (5): 587–603. doi: 10.1097/PAS.0000000000001650
- Peiris S., Mesa H., Aysola A. et al. Pathological findings in organs and tissues of patients with COVID-19: A systematic review. PLoS One. 2021; 16 (4): e0250708. doi: 10.1371/journal.pone.0250708
- Torge D., Bernardi S., Arcangeli M. et al. Histopathological Features of SARS-CoV-2 in Extrapulmonary Organ Infection: A Systematic Review of Literature. Pathogens. 2022; 11 (8): 867. doi: 10.3390/pathogens11080867
- Zhao C.L., Rapkiewicz A., Maghsoodi-Deerwester M. et al. Pathological findings in the postmortem liver of patients with coronavirus disease 2019 (COVID-19). Hum Pathol. 2021; 109: 59–68. doi: 10.1016/j.humpath.2020.11.015
- Jeyalan V., Storrar J., Wu H.H.L. et al. Native and transplant kidney histopathological manifestations in association with COVID-19 infection: A systematic review. World J Transplant. 2021; 11 (11): 480–502. doi: 10.5500/wjt.v11.i11.480
- Akilesh S., Nast C.C., Yamashita M. et al. Multicenter Clinicopathologic Correlation of Kidney Biopsies Performed in COVID-19 Patients Presenting With Acute Kidney Injury or Proteinuria. Am J Kidney Dis. 2021; 77 (1): 82–93.e1. doi: 10.1053/j.ajkd.2020.10.001
- Sharma P., Uppal N.N., Wanchoo R. et al. COVID-19–Associated Kidney Injury: A Case Series of Kidney Biopsy Findings. J Am Soc Nephrol. 2020; 31 (9): 1948–58. doi: 10.1681/ASN.2020050699
- Sadeghzadeh-Bazargan A., Rezai M., Najar Nobari N. et al. Skin manifestations as potential symptoms of diffuse vascular injury in critical COVID-19 patients. J Cutan Pathol. 2021; 48 (10): 1266–76. doi: 10.1111/cup.14059
- Bradley B.T., Maioli H., Johnston R. et al. Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series. Lancet. 2020; 396 (10247): 320–32. doi: 10.1016/S0140-6736(20)31305-2
- Almamlouk R., Kashour T., Obeidat S. et al. COVID-19–Associated cardiac pathology at the postmortem evaluation: a collaborative systematic review. Clin Microbiol Infect. 2022; 28 (8): 1066–75. doi: 10.1016/j.cmi.2022.03.021
- Varga Z., Flammer A.J., Steiger P. et al. Endothelial cell infection and endotheliitis in COVID-19. Lancet (London, England). 2020; 395 (10234): 1417–8. doi: 10.1016/S0140-6736(20)30937-5
- Bearse M., Hung Y.P., Krauson A.J. et al. Factors associated with myocardial SARS-CoV-2 infection, myocarditis, and cardiac inflammation in patients with COVID-19. Mod Pathol. 2021; 34 (7): 1345–57. doi: 10.1038/s41379-021-00790-1
- Menter T., Haslbauer J.D., Nienhold R. et al. Postmortem examination of COVID-19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction. Histopathology. 2020; 77 (2): 198–209. doi: 10.1111/his.14134
- Vasquez-Bonilla W.O., Orozco R., Argueta V. et al. A review of the main histopathological findings in coronavirus disease 2019. Hum Pathol. 2020; 105: 74–83. doi: 10.1016/j.humpath.2020.07.023
- Maiese A., Manetti A.C., Bosetti C. et al. SARS-CoV-2 and the brain: A review of the current knowledge on neuropathology in COVID-19. Brain Pathol. 2021; 31 (6): e13013. doi: 10.1111/bpa.13013
- Mukerji S.S., Solomon I.H. What can we learn from brain autopsies in COVID-19? Neurosci Lett. 2021; 742: 135528. doi: 10.1016/j.neulet.2020.135528
- Li Y.C., Zhang Y., Tan B.H. What can cerebrospinal fluid testing and brain autopsies tell us about viral neuroinvasion of SARS-CoV-2. J Med Virol. 2021; 93 (7): 4247–57. doi: 10.1002/jmv.26943
- Ruz-Caracuel I., Pian-Arias H., Corral I. et al. Neuropathological findings in fatal COVID-19 and their associated neurological clinical manifestations. Pathology. 2022; 54 (6): 738–45. doi: 10.1016/j.pathol.2022.03.006
- Thakur K.T., Miller E.H., Glendinning M.D. et al. COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital. Brain. 2021; 144 (9): 2696–708. doi: 10.1093/brain/awab148
- Ho C.Y., Salimian M., Hegert J. et al. Postmortem Assessment of Olfactory Tissue Degeneration and Microvasculopathy in Patients with COVID-19. JAMA Neurol. 2022; 79 (6): 544–53. doi: 10.1001/jamaneurol.2022.0154
- Matschke J., Lütgehetmann M., Hagel C. et al. Neuropathology of patients with COVID-19 in Germany: a post-mortem case series. Lancet Neurol. 2020; 19 (11): 919–29. doi: 10.1016/S1474-4422(20)30308-2
- Serrano G.E., Walker J.E., Tremblay C. et al. SARS-CoV-2 Brain Regional Detection, Histopathology, Gene Expression, and Immunomodulatory Changes in Decedents with COVID-19. J Neuropathol Exp Neurol. 2022; 81 (9): 666–95. doi: 10.1093/jnen/nlac056
- Ackermann M., Verleden S.E., Kuehnel M. et al. Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19. N Engl J Med. 2020; 383 (2): 120–8. doi: 10.1056/nejmoa2015432
- Maccio U., Zinkernagel A.S., Shambat S.M. et al. SARS-CoV-2 leads to a small vessel endotheliitis in the heart. EBioMedicine. 2021; 63: 103182. doi: 10.1016/j.ebiom.2020.103182
- Di Girolamo R., Khalil A., Alameddine S. et al. Placental histopathology after SARS-CoV-2 infection in pregnancy: a systematic review and meta-analysis. Am J Obstet Gynecol MFM. 2021; 3 (6): 100468. doi: 10.1016/j.ajogmf.2021.100468
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