Visualize correlations using heat maps in R

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Abstract

The role of gut microbiota in maintaining of homeostasis and development of pathophysiological disorders has been actively studied over the past decades. With the advent of genome sequencing technology, new opportunities are opening up in this area. With the advent the technology of genome sequencing, new opportunities are opening up in this area. During statistical processing, there is a need to perform correlation analysis. However, with a large number of indicators, visual presentation of data can be difficult. Heat maps allow you to graphically represent large amount of data. The article contains a methodology of graphically representing correlations using heat maps.

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About the authors

V. B. Grinevich

Kirov Military Medical Academy

Email: gulnara533@gmail.com

MD, Professor

Russian Federation, Saint Petersburg

G. F. Bunenkova

Kirov Military Medical Academy

Author for correspondence.
Email: gulnara533@gmail.com
Russian Federation, Saint Petersburg

S. P. Salikova

Kirov Military Medical Academy

Email: gulnara533@gmail.com

MD

Russian Federation, Saint Petersburg

D. V. Egorov

Kirov Military Medical Academy

Email: gulnara533@gmail.com

Candidate of Medical Sciences

Russian Federation, Saint Petersburg

Yu. A. Lazareva

Kirov Military Medical Academy

Email: gulnara533@gmail.com
Russian Federation, Saint Petersburg

S. N. Petrukov

Kirov Military Medical Academy

Email: gulnara533@gmail.com
Russian Federation, Saint Petersburg

R. G. Guseinov

Saint Luke Clinical Hospital

Email: gulnara533@gmail.com
Russian Federation, Saint Petersburg

V. V. Perepelitsa

Saint Luke Clinical Hospital

Email: gulnara533@gmail.com
Russian Federation, Saint Petersburg

N. S. Bunenkov

Pavlov First Saint Petersburg State Medical University

Email: gulnara533@gmail.com
Russian Federation, Saint Petersburg

S. V. Popov

Saint Luke Clinical Hospital

Email: gulnara533@gmail.com
Russian Federation, Saint Petersburg

References

  1. Esipova O.Y., Bogdanov V.K., Esipov A.S. at al. Development of a new low-volume oxygenator and creation of a hydrodynamic test bench for ex vivo lung perfusion in small animals. Russian Journal of Transplantology and Artificial Organs. 2023; 25 (3): 106–12. doi: 10.15825/1995-1191-2023-3-106-112
  2. Gautier S.V., Tsirulnikova O.M., Pashkov I.V. at al. Normothermic ex vivo perfusion of isolated lungs in an experiment using a russian-made perfusion system. Russian Journal of Transplantology and Artificial Organs. 2022; 24 (2): 94–101. doi: 10.15825/1995-1191-2022-2-94-101
  3. Pashkov I.V., Gautier S.V., Bogdanov V.K., at al. Normothermic ex vivo lung perfusion using a developed solution followed by orthotopic left lung transplantation (experimental study). Russian Journal of Transplantology and Artificial Organs. 2023; 25 (2): 158–66. doi: 10.15825/1995-1191-2023-2-158-166
  4. Егошин В.Л., Иванов С.В., Саввина Н.В. и др. Визуализация исследовательских данных с использованием программной среды R. Экология человека. 2018; 8: 52–64 [Egoshin V.L., Ivanov S.V., Savvina N.V. et al. Visualization of Biomedical Data Using R. Human Ecology. 2018; 8: 52–64 (in Russ.)].
  5. Егошин В.Л., Иванов С.В., Саввина Н.В. и др. Расчет показателей описательной статистики с использованием программной среды R. Экология человека. 2018; 9: 55–64 [Egoshin V.L., Ivanov S.V., Savvina N.V. et al. Descriptive Statistics Using R. Human Ecology. 2018; 9: 55–64 (in Russ.)].
  6. Gautier S.V., Tsirulnikova O.M., Pashkov I.V. at al. Evaluation of the efficacy of a novel perfusion solution for normothermic ex vivo lung perfusion compared with Steen solution™ (animal experimental study). Russian Journal of Transplantology and Artificial Organs. 2021; 23 (3): 82–9. doi: 10.15825/1995-1191-2021-3-82-89
  7. Буненков Н.С., Буненкова Г.Ф., Комок В.В. и др. SAS Enterprise Guide 6.1 для врачей: сравнение групп. Медицинский академический журнал. 2019; 19 (4): 33–40 [Bunenkov N.S., Bunenkova G.F., Komok V.V. et al. SAS Enterprise Guide 6.1 for physicians: multiple comparisons. Medical academic journal. doi: 10.17816/MAJ17736 (in Russ.)].
  8. Буненков Н.С., Буненкова Г.Ф., Комок В.В., и др. SAS Enterprise Guide 6.1 для врачей: корреляционный анализ. Медицинский академический журнал. 2020; 20 (1): 51–6 [Bunenkov N.S., Bunenkova G.F., Komok V.V. et al. SAS Enterprise Guide 6.1 for physicians: correlation analysis. Medical academic journal. 2020; 20 (1): 51–6 (in Russ.)]. doi: 10.17816/MAJ17737
  9. Гржибовский А.М. Типы данных, проверка распределения и описательная статистика. Экология человека. 2008; 1: 52–8 [Grzybowski A.M. Data types, control of distribution and descriptive statistics. Human Ecology. 2008; 1: 52-8 (in Russ.)].
  10. Ким А.Д., Лепехова С.А., Чашкова Е.Ю. и др. Результаты оценки микробиоты в условиях экспериментального язвенного поражения толстой кишки анализ. Бюллетень сибирской медицины. 2021; 20 (1): 59–66 [Kim A.D., Lepekhova S.A., Chashkova E.Y. et al. Results of the microbiota assessment in experimental ulcerative colitis. Bulletin of Siberian Medicine. 2021; 20 (1): 59–66 (in Russ.)]. doi: 10.20538/1682-0363-2021-1-59-66
  11. Sung J., Rajendraprasad S.S., Philbrick K.L. et al. The human gut microbiome in critical illness: disruptions, consequences, and therapeutic frontiers. J Crit Care. 2024; 79: 154436. doi: 10.1016/j.jcrc.2023.154436
  12. Гржибовский А.М., Иванов С.В., Горбатова М.А. Корреляционный анализ данных с использованием программного обеспечения Statistica и SPSS. Наука и здравоохранение. 2017; 1: 7–36 [Grzhibovsky A.M., Ivanov S.V., Gorbatova M.A. Correlation analysis of data using Statistica and SPSS software. Science & Healthcare. 2017; 1: 7–36 (in Russ.)].
  13. Унгуряну Т.Н., Гржибовский А.М. Краткие рекомендации по описанию, статистическому анализу и представлению данных в научных публикациях. Экология человека. 2011; 5: 55–60 [Unguryanu T.N., Grjibovski A.M. Brief recommendations on description, analysis and presentation of data in scientific papers. Human Ecology. 2011; 5: 55–60 (in Russ.)].
  14. Егошин В.Л., Иванов С.В., Саввина Н.В. и др. Корреляционный и простой линейный регрессионный анализ с использованием программной среды R. Экология человека. 2018; 12: 55–64 [Egoshin V.L., Ivanov S.V., Savvina N.V. et al. Correlation and simple regression analysis using R. Human Ecology. 2018; 12: 55–64 (in Russ.)].
  15. Ушаков В.Г., Ушаков Н.Г. Критерии нормальности вероятностного распределения при округленных данных. Информатика и ее применение. 2023; 17 (1): 18–27 [Ushakov V.G., Ushakov N.G. Tests for normality of the probabilistic distribution when data are rounded. Informatics and Applications. 2023; 17 (1): 18–27 (in Russ.)]. doi: 10.14357/19922264230103

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2. Heat map of correlations between abundance of microorganism species and urinalysis parameters

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