Comparative study of the adsorption activity of enterosorbents by spectrophotometric method

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

At the present stage in practice enterosorbents are used, which differ in dosage form, chemical structure, selectivity and mechanisms of action. When choosing an enterosorbent to include it in the complex therapy it is necessary to take into account the presence of high adsorption activity (AA) of the drug.

Objective. To compare AA of sorbents under conditions close to physiological
ones.

Materials and methods. The AA of medical sorbents (Alesorb®) in the form of ALESORB® “Enterosorbent” powder and Polysorb® powder; ALESORB® “Enterosorbent Gel” ERCIG without flavourings and Enterosgel® paste was studied by spectrophotometric method using methyl orange and gelatin as adsorption markers at pH = 2.0 and pH = 7.5, simulating the environment of the stomach and duodenum.

Results. The obtained data indicate that the level of AA of sorbing agent (Alesorb®) in the form of ALESORB® “Enterosorbent” powder and ALESORB® “Enterosorbent Gel” ERCIG without flavourings with respect to the used marker substances, are superior to Polysorb® powder and Enterosgel® paste. The obtained results give a reason to consider sorbing agents (Alesorb®) in the form of ALESORB® “Enterosorbent” powder and ALESORB® “Enterosorbent Gel” ERCIG without flavourings as effective and priority means for prevention and treatment of diseases, in the therapy of which enterosorption is envisaged.

Full Text

Restricted Access

About the authors

E. A. Orlova

Penza Institute for Postgraduate Medical Education – a Branch Campus of the Russian Medical Academy of Continuous Professional Education

Author for correspondence.
Email: lisaorl@yandex.ru

MD, Professor

Russian Federation, Penza

О. A. Levashova

Penza Institute for Postgraduate Medical Education – a Branch Campus of the Russian Medical Academy of Continuous Professional Education

Email: lisaorl@yandex.ru

Candidate of Biological Sciences

Russian Federation, Penza

T. A. Druzhinina

Penza Institute for Postgraduate Medical Education – a Branch Campus of the Russian Medical Academy of Continuous Professional Education

Email: lisaorl@yandex.ru

Candidate of Biological Sciences

Russian Federation, Penza

A. S. Sysoeva

Penza Institute for Postgraduate Medical Education – a Branch Campus of the Russian Medical Academy of Continuous Professional Education

Email: lisaorl@yandex.ru
Russian Federation, Penza

References

  1. Code C.F. The semantics of the process of absorption. Perspect Biol Med. 1960; 3: 560–2. doi: 10.1353/pbm.1960.0022
  2. Лопаткин Н.А., Лопухин, Ю.М. Эфферентные методы в медицине. М.: Медицина, 1989; 352 с. [Lopatkin N. A., Lopuhin, Yu. M. Efferentnye metody v meditsine. M.: Meditsina, 1989; 352 p. (in Russ.)].
  3. Andersen A.H. Experimental studies on the pharmacology of activated charcoal; adsorption power of charcoal in aqueous solutions. Acta Pharmacol Toxicol (Copenh). 1946; 2 (1): 69–78. doi: 10.1111/j.1600-0773.1946.tb02599.x
  4. Орлова Е.А., Кандрашкина Ю.А. Применение энтеросорбента алесорб гель в комплексной терапии атопического дерматита. Врач. 2021; 32 (4): 66–71 [Orlova E., Kandrashkina Yu. Use of the enterosorbent Alesorb gel in the combination therapy of atopic dermatitis. Vrach. 2021; 32 (4): 66–71 (in Russ.)]. doi: 10.29296/25877305-2021-04-12
  5. Бородин Ю.И., Рачковская Л.Н. Энтеросорбция и энтеросорбенты. Консилиум. 2000; 3 (13): 11–3 [Borodin Y.I., Rachkovskaya L.N. Enterosorbciya i enterosorbenty. Konsilium. 2000; 3 (13): 11–3 (in Russ.)].
  6. ОФС.1.2.3.0021.15. Общая фармакопейная статья. Определение адсорбционной активности энтеросорбентов (утв. и введена в действие Приказом Минздрава России от 31.10.2018 №749) [OFS.1.2.3.0021.15. Obshchaya farmakopeinaya stat'ya. Opredelenie adsorbtsionnoi aktivnosti enterosorbentov (utv. i vvedena v deistvie Prikazom Minzdrava Rossii ot 31.10.2018 №749) (in Russ.)].
  7. Ismailov M.G., Makhkamov Kh.M., Ismailov P.L. High-efficiency carbonaceous medical sorbent made from cotton lignin. Pharmaceutical Chemistry Journal. 2000; 34 (12): 666–8. doi: 10.1023/A:1010460020089
  8. Герникова Е.П., Лутцева А.И., Боковикова Т.Н. и др. Определение адсорбционной активности энтеросорбентов. Ведомости Научного центра экспертизы средств медицинского применения. Регуляторные исследования и экспертиза лекарственных средств. 2013; 4: 47–50 [Gernikova E.P., Lutseva A.I., Bokovikova T.N. et al. Evaluation of the adsorption activity of enterosorbents. The Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products. Regulatory Research and Medicine Evaluation. 2013; 4: 47–50 (in Russ.)].
  9. Markelov D.A., Nitsak O.V., Gerashchenko I.I. Comparative study of the adsorption activity of medicinal sorbents. Pharmaceutical Chemistry Journal. 2008; 42 (7): 405–8. doi: 10.1007/s11094-008-0138-2
  10. Жиляева М.А. Разработка и усовершенствование методов контроля и стандартизации лекарственных средств из группы энтеросорбентов: Энтеросгель, Полисорб МП®, таблетки угля активированного. Автореф. дисс. ... канд. фарм. наук. М., 2000; 24 с. [Zhilyaeva M.A. Razrabotka i usovershenstvovanie metodov kontrolya i standartizatsii lekarstvennykh sredstv iz gruppy enterosorbentov: Enterosgel', polisorb MP, tabletki uglya aktivirovannogo. Avtoref. diss. ... kand. farm. nauk. M., 2000; 24 р. (in Russ.)].
  11. Ворсина И.А., Григорьева Т.Ф., Баринова А.П. и др. Механохимическое взаимодействие диоксида кремния с органическими кислотами. Химия в интересах устойчивого развития. 2011; 19 (5): 485–94 [Vorsina I.A., Grigorieva T.F., Barinova A.P. et al. Mechanochemical interaction of silicon dioxide with organic acids. Khimiya v interesakh ustoichivogo razvitiya. 2011; 19 (5): 485–94 (in Russ.)].
  12. Stutz H. Protein attachment onto silica surfaces-a survey of molecular fundamentals, resulting effects and novel preventive strategies in CE. Electrophoresis. 2009; 30 (12): 2032–61. doi: 10.1002/elps.200900015
  13. Аутов С.А., Базарнова Н.Г., Кушнир Е.Ю. Микрокристаллическая целлюлоза: структура, свойства и области применения. Химия растительного сырья. 2013; 3: 33–41 [Autov S.A., Bazarnova N.G., Kushnir E.Yu. Mikrokristallicheskaya tsellyuloza: struktura, svoistva i oblasti primeneniya. Khimiya rastitel'nogo syr'ya. 2013; 3: 33–41 (in Russ.)].
  14. Fazilova S.A., Burkhanova N.D., Yugai S.M. et al. Molecular and supramolecular interactions in systems based on microcrystalline cellulose and trichlorophene. Pharmaceutical chemistry journal. 2005; 39 (12): 658–62 (in Russ.)]. doi: 10.1007/s11094-006-0041-7

Supplementary files

Supplementary Files
Action
1. JATS XML
Download
2. Fig. 1. Adsorption activity of enterosorbents determined using methyl orange adsorption marker at pH simulating stomach environment (pH = 2.0)

Download (95KB)
Indexing metadata
3. Fig. 2. Adsorption activity of enterosorbents determined using methyl orange adsorption marker at pH simulating duodenal environment (pH = 7.5)

Download (100KB)
Indexing metadata
4. Fig. 3. Adsorption activity of enterosorbents determined using a gelatin adsorption marker at pH simulating stomach environment (pH = 2.0)

Download (105KB)
Indexing metadata
5. Fig. 4. Adsorption activity of enterosorbents determined using a gelatin adsorption marker at pH simulating duodenal environment (pH = 7.5)

Download (110KB)
Indexing metadata

Copyright (c) 2025 Russkiy Vrach Publishing House