Comparative study of the adsorption activity of enterosorbents by spectrophotometric method

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At the present stage in practice enterosorbents are used, which differ in dosage form, chemical structure, selectivity and mechanisms of action. When choosing an enterosorbent to include it in the complex therapy it is necessary to take into account the presence of high adsorption activity (AA) of the drug.

Objective. To compare AA of sorbents under conditions close to physiological
ones.

Materials and methods. The AA of medical sorbents (Alesorb®) in the form of ALESORB® “Enterosorbent” powder and Polysorb® powder; ALESORB® “Enterosorbent Gel” ERCIG without flavourings and Enterosgel® paste was studied by spectrophotometric method using methyl orange and gelatin as adsorption markers at pH = 2.0 and pH = 7.5, simulating the environment of the stomach and duodenum.

Results. The obtained data indicate that the level of AA of sorbing agent (Alesorb®) in the form of ALESORB® “Enterosorbent” powder and ALESORB® “Enterosorbent Gel” ERCIG without flavourings with respect to the used marker substances, are superior to Polysorb® powder and Enterosgel® paste. The obtained results give a reason to consider sorbing agents (Alesorb®) in the form of ALESORB® “Enterosorbent” powder and ALESORB® “Enterosorbent Gel” ERCIG without flavourings as effective and priority means for prevention and treatment of diseases, in the therapy of which enterosorption is envisaged.

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作者简介

E. Orlova

Penza Institute for Postgraduate Medical Education – a Branch Campus of the Russian Medical Academy of Continuous Professional Education

编辑信件的主要联系方式.
Email: lisaorl@yandex.ru

MD, Professor

俄罗斯联邦, Penza

О. Levashova

Penza Institute for Postgraduate Medical Education – a Branch Campus of the Russian Medical Academy of Continuous Professional Education

Email: lisaorl@yandex.ru

Candidate of Biological Sciences

俄罗斯联邦, Penza

T. Druzhinina

Penza Institute for Postgraduate Medical Education – a Branch Campus of the Russian Medical Academy of Continuous Professional Education

Email: lisaorl@yandex.ru

Candidate of Biological Sciences

俄罗斯联邦, Penza

A. Sysoeva

Penza Institute for Postgraduate Medical Education – a Branch Campus of the Russian Medical Academy of Continuous Professional Education

Email: lisaorl@yandex.ru
俄罗斯联邦, Penza

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2. Fig. 1. Adsorption activity of enterosorbents determined using methyl orange adsorption marker at pH simulating stomach environment (pH = 2.0)

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3. Fig. 2. Adsorption activity of enterosorbents determined using methyl orange adsorption marker at pH simulating duodenal environment (pH = 7.5)

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4. Fig. 3. Adsorption activity of enterosorbents determined using a gelatin adsorption marker at pH simulating stomach environment (pH = 2.0)

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5. Fig. 4. Adsorption activity of enterosorbents determined using a gelatin adsorption marker at pH simulating duodenal environment (pH = 7.5)

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