Phenotype of a patient with arterial hypertension combined with chronic obstructive pulmonary disease with frequent exacerbations

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Abstract

Objective. To study the phenotypic features of arterial hypertension (AH) in patients with frequent exacerbations of chronic obstructive pulmonary disease (COPD).

Materials and methods. 251 patients (127 men, 124 women) aged 45 to 59 years with a history of AH in combination with COPD were examined. For comparative analysis, all patients included in the study were divided into three groups: group 1
(n=101) – patients with AH and COPD without frequent exacerbations (GOLD category A and B); group 2 (n=98) – patients with AH and COPD with frequent exacerbations (category E); group 3 (n=52) – patients with AH without COPD. Patients underwent a comprehensive examination, including an analysis of the frequency of exacerbations and severity of COPD symptoms (filling out MMRs and CAT questionnaires), office blood pressure measurement with calculation of pulse pressure, daily blood pressure monitoring, echocardiography.

Results. The combination of AH with frequent exacerbations of COPD can be considered as a separate phenotype of the disease, which is characterized by greater severity of shortness of breath, sleep disorders caused by night cough attacks, increased heart rate, diastolic blood pressure, pulmonary hypertension, an unfavorable daily profile with insufficient decrease or increase in blood pressure at night (non-dippers, night-peakers) and high daily variability of blood pressure.

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About the authors

A. A. Abildaeva

Novosibirsk State Medical University, Ministry of Health of Russia

Email: h_ludmila73@mail.ru
ORCID iD: 0000-0002-6260-7102
SPIN-code: 6750-0550
Russian Federation, Novosibirsk

L. D. Khidirova

Novosibirsk State Medical University, Ministry of Health of Russia; Novosibirsk Regional Clinical Cardiology Dispensary

Email: h_ludmila73@mail.ru
ORCID iD: 0000-0002-1250-8798
SPIN-code: 7932-6544

Professor, MD

Russian Federation, Novosibirsk; Novosibirsk

L. A. Shpagina

Novosibirsk State Medical University, Ministry of Health of Russia; City Clinical Hospital No.2, Novosibirsk

Author for correspondence.
Email: h_ludmila73@mail.ru
ORCID iD: 0000-0003-0871-7551
SPIN-code: 5773-6649

Professor, MD

Russian Federation, Novosibirsk; Novosibirsk

I. S. Shpagin

Novosibirsk State Medical University, Ministry of Health of Russia; City Clinical Hospital No.2, Novosibirsk

Email: h_ludmila73@mail.ru
ORCID iD: 0000-0002-3109-9811
SPIN-code: 2892-6184

Professor, MD

Russian Federation, Novosibirsk; Novosibirsk

References

  1. Rabahi M.F., Pereira S.A., Silva Júnior J.L. et al. Prevalence of chronic obstructive pulmonary disease among patients with systemic arterial hypertension without respiratory symptoms. Int J Chron Obstruct Pulmon Dis. 2015; 10 (1): 1525–9. doi: 10.2147/COPD.S85588
  2. Almagro P., Cabrera F.J., Diez J. et al. Comorbidities and short-term prognosis in patients hospitalized for acute exacerbation of COPD. The ESMI study. Chest. 2012; 142 (5): 1126–33. doi: 10.1378/chest.11-2413
  3. Park H.J., Leem A.Y., Lee S.H. et al. Comorbidities in obstructive lung disease in Korea: data from the fourth and fifth Korean National Health and Nutrition Examination Survey. Int J Chron Obstruct Pulmon Dis. 2015; 10: 1571–82. doi: 10.2147/COPD.S85767
  4. Hillas G., Perlikos F., Tsiligianni I. et al. Managing comorbidities in COPD. Int J Chron Obstruct Pulmon Dis. 2015; 10: 95–109. doi: 10.2147/COPD.S54473
  5. Чазова И.Е., Невзорова В.А., Амбатьелло Л.Г. и др. Клинические рекомендации по диагностике и лечению пациентов с артериальной гипертензией и хронической обструктивной болезнью легких. Системные гипертензии. 2020; 17 (3): 7–34 [Chazova I.E., Nevzorova V.A., Ambatiello L.G. et al. Clinical practice guidelines on the diagnosis and treatment of patients with arterial hypertension and chronic obstructive pulmonary disease. Systemic Hypertension. 2020; 17 (3): 7–34 (in Russ.)]. doi: 10.26442/2075082X.2020.3.200294
  6. Anthonisen N.R., Connett J.E., Enright P.L. et al. Hospitalizations and mortality in the Lung Health Study. Am J Respir Crit Care Med. 2002; 166 (3): 333–9. doi: 10.1164/rccm.2110093
  7. Клинические рекомендации. Артериальная гипертензия у взрослых. Российское кардиологическое общество, 2024 [Clinical guidelines. Arterial hypertension in adults. Russian Society of Cardiology, 2024 (in Russ.)]. URL: https://scardio.ru/content/Guidelines/2024_AG.pdf
  8. Козлов Е.В., Яскевич Р.А., Москаленко О.Л. и др. Особенности показателей суточного мониторирования артериального давления у мужчин с хронической обструктивной болезнью легких в условиях коморбидности. Siberian Journal of Life Sciences and Agriculture. 2019; 11 (4): 38–55 [Kozlov E.V., Yaskevich R.A., Moskalenko O.L. et al. Features of indicators of daily monitoring of arterial pressure in men with chronic obstructive pulmonary disease in the context of comorbidity. Siberian Journal of Life Sciences and Agriculture. 2019; 11 (4): 38–55 (in Russ.)]. doi: 10.12731/2658-6649-2019-11-4-38-55
  9. Григорьева Н.Ю. Коморбидный пациент с артериальной гипертонией и ХОБЛ. Лечащий врач. 2016; 7: 24–7 [Grigorieva N.Yu. Comorbid patient with arterial hypertension and COPD. Lechaschi Vrach. 2016; 7: 24–7 (in Russ.)].
  10. Чесникова А.И., Сафроненко В.А., Скаржинская Н.С. и др. Особенности артериальной гипертензии у коморбидных больных. Медицинский вестник Юга России. 2017; 1: 32–8 [Chesnikova A.I., Safronenko V.A., Skarzhinskaya N.S., et al. Features of arterial hypertension in patients with comorbidity. Medical Herald of the South of Russia. 2017; 1: 32–8 (in Russ.)]. doi: 10.21886/2219-8075-2017-1-32-38
  11. Cicek Y., Durakoglugil M.E., Kocaman S.A. et al. Non-dipping pattern in untreated hypertensive patients is related to increased pulse wave velocity independent of raised nocturnal blood pressure. Blood Press. 2013; 22 (1): 34–8. doi: 10.3109/08037051.2012.701409
  12. Cuspidi C., Sala C., Tadic M. et al. Nondipping pattern and carotid atherosclerosis: a systematic review and meta-analysis. J Hypertens. 2016; 34 (3): 382–5. doi: 10.1097/HJH.0000000000000812
  13. Задионченко В.С., Адашева Т.В., Федорова И.В. и др. Артериальная гипертония и хроническая обструктивная болезнь легких: клинико-патогенетические параллели и возможности терапии. Российский кардиологический журнал. 2009; 6: 62–8 [Zadionchenko V.S., Adasheva T.V., Fedorova I.V. et al. Arterial hypertension and chronic obstructive pulmonary disease: clinico-pathogenetic parallels and therapeutic potential. Russian Journal of Cardiology. 2009; 6: 62–8 (in Russ.)].
  14. Cavaille’s A., Brinchault-Rabin G., Dixmier A. Comorbidities of COPD. Eur Respir Rev. 2013; 22 (130): 454–75. doi: 10.1183/09059180.00008612
  15. Кушникова И.П., Граудина В.Е. Сердечно-сосудистая патология у больных хронической обструктивной болезнью легких: клинико-патогенетические особенности и диагностика. Вестник СурГУ. Медицина. 2019; 1: 8–13 [Kushnikova I.P., Graudina V.E. Cardiovascular pathology in patients with chronic obstructive pulmonary disease: clinical and pathogenetic features and diagnostics. Vestnik SurGU. Meditsina. 2019; (1): 8–13 (in Russ.)].
  16. Хидирова Л.Д., Шпагина Л.А., Шпагин И.С. и др. Актуальные проблемы фармакотерапии у коморбидных больных артериальной гипертонией и хронической обструктивной болезнью легких. Атмосфера. Новости кардиологии. 2023; 1: 22–7 [Khidirova L.D., Shpagina L.A., Shpagin I.S. et al. Urgent Problems of Pharmacological Management of Comorbid Patients with Hypertension and Chronic Obstructive Pulmonary Disease. Atmosfera. Novosti kardiologii. 2023; 1: 22–7 (in Russ.)]. doi: 10.24412/2076-4189-2023-12838
  17. Swedberg K., Komajda M., Böhm M. Ivabradine and outcomes in chronic heart failure (SHIF): a randomised placebo-controlled study. Lancet. 2010; 376 (9744): 875–85. doi: 10.1016/S0140-6736(10)61198-1
  18. Авдеев С.Н. Хроническая обструктивная болезнь легких как системное заболевание. Пульмонология. 2007; 2: 104–16 [Avdeev S.N. COPD as a systemic disease. PULMONOLOGIYA. 2007; 2: 104–16 (in Russ.)]. doi: 10.18093/0869-0189-2007-0-2-104-116
  19. Крючкова О.Н., Турна Э.Ю., Мартынюк М.А. Артериальная гипертензия у больных ХОБЛ: патогенетические особенности и суточная динамика артериального давления. Крымский терапевтический журнал. 2015; 2: 5–9 [Kryuchkova O.N., Turna E.U., Martynyuk M.A. Arterial hypertension in patients with chronic obstructive pulmonary disease: pathogenetic features and daily dynamics of blood pressure. Crimean Journal of Internal Diseases. 2015; 2: 5–9 (in Russ.)].

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