Association of variant rs1799752 of ACE gene with metabolic syndrome in young residents of Khanty-Mansiysk autonomous okrug – Yugra

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Abstract

Objective. To investigate the association of variant rs1799752 of the ACE gene with metabolic disorders in young residents of the Khanty-Mansiysk Autonomous Okrug – Yugra (KhMAO-Yugra).

Materials and methods. A comparative anthropometric, biochemical, molecular genetic examination of indigenous and non-indigenous young residents was carried out. The genotyping of the insertion variant was carried out through the synthesis of the corresponding DNA fragment of the ACE gene by polymerase chain reaction and analysis of the length of the products.

Results. In the general sample, allele I (52.6%) and heterozygous genotype ID (51.4%) were more common. A statistically significant association with fasting plasma glucose levels (p = 0.029 and p = 0.008) was found in the general sample of young residents, as well as in indigenous residents, carriers of genotype II. In the general sample and in non-indigenous residents of KhMAO-Yugra, carriers of the DD genotype, an associative relationship was found with the median systolic blood pressure (p = 0.017 and p = 0.042).

Conclusions. Metabolic syndrome is more often associated with the rs1799752 variant of the ACE gene in non-indigenous women with the ID genotype (p = 0.027), in non-indigenous men with the DD genotype (p = 0.019).

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About the authors

E. V. Korneeva

Surgut State University

Author for correspondence.
Email: evkorneeva39@rambler.ru
ORCID iD: 0000-0002-0143-982X
SPIN-code: 4498-5501

Associate Professor, Candidate of Medical Sciences

Russian Federation, Surgut

M. I. Voevoda

Federal Research Center for Fundamental and Translational Medicine

Email: evkorneeva39@rambler.ru
ORCID iD: 0000-0001-9425-413X
SPIN-code: 6133-1780

Professor, Academician of the Russian Academy of Sciences, MD

Russian Federation, Novosibirsk

V. N. Maksimov

Research Institute of Internal and Preventive Medicine – Branch of Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences

Email: evkorneeva39@rambler.ru
ORCID iD: 0000-0002-7165-4496
SPIN-code: 9953-7867

Associate Professor, MD

Russian Federation, Novosibirsk

S. E. Semaev

Research Institute of Internal and Preventive Medicine – Branch of Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences

Email: evkorneeva39@rambler.ru
ORCID iD: 0000-0003-3999-8501
SPIN-code: 9641-2299
Russian Federation, Novosibirsk

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