Vol 28, No 8 (2017)

The paper summarizes an update on the etiology and pathogenesis, clinical symptoms, diagnosis, and treatment of one of the orphan diseases - osteogenesis imperfecta.

The cervical cytological and colposcopic characteristics depending on the phase of the climacteric (peri- and postmenopausal) period, which have been established in the comprehensive examination of patients with genitourinary syndrome of menopause, justify the use of local estrogen therapy.

The therapeutic efficacy of Osteomed Forte was evaluated in the complex rehabilitation of children with infantile cerebral palsy.

The medical history data correctly collected from pregnant women allow groups at high risk for premature birth to be formed to implement preventive measures.

The concept of chronic kidney disease is being widely introduced into practical medicine all over the world. This term reveals the essence of the problem based on the data of modern science. But physicians of different specialties do not always agree with the relevance of this term and the need for its use.

The use of the immunosuppressive drug cyclosporine A was successful in a 17-year-old adolescent with extremely severe atopic dermatitis.

Based on the high frequency of dysfunction of brainstem structures and epileptiform activity in the absence of clinical manifestations in children with speech retardation, the author proposes a treatment algorithm that takes into account the functional state of the nervous system.

The features of the course and outcomes of multiple organ dysfunction syndrome were investigated in newborn infants in relation to gestational age and birth weight. The frequency of a severe central nervous system lesion and the severity of bronchopulmonary dysplasia and retinopathy were found to increase with decreases in gestational age and birth weight.

The safety and efficiency of nicorandil therapy during optimal medical therapy and its impact on left ventricular (LV) remodeling and function were evaluated in patients with stable ischemic heart disease complicated by chronic heart failure with a low LV ejection fraction.

Patients with new-onset multidrug-resistant tuberculosis treated with ethionamide/ protionamide and para-aminosalicylic acid were noted to have manifestations of hypothyroidism, which were especially pronounced after 4 and 5 months of therapy

The analysis of variance test (ANOVA) analyzing the groups having discrete data was used to compare ovarian reserve parameters and to study their value in predicting the outcome of infertility treatment in 150 women with polycystic ovary syndrome (PCOS) and thyroid disorder. The data analysis demonstrates a significant correlation between the volume of the ovary and the size of its ovarian reserve and no relationship between the level of basal follicle-stimulating hormone and the occurrence of pregnancy. The ovarian reserve is higher in PCOS concurrent with thyroid disease than in PCOS only. At the same time, the ovarian reserve in associated pathology is higher in patients with PCOS and hypothyroidism. A link was found between age, ovarian volume, number of antral follicles, and a positive outcome of treatment - the onset of pregnancy.

Urinary tract infection is a common abnormality in babies. For its diagnosis, the maximum bladder volume, residual urine volume, and bladder wall thickness are determined from ultrasonographic findings.

The safety and efficiency of immunization against rotavirus infection were evaluated based on a long-term analysis of the incidence of enteric infections, by using one of the areas of the Moscow region as an example. The paper provides data on the dominance of rotavirus enteritis in the etiological structure of acute enteric infections. The genotypes of rotaviruses matching to pentavalent RotaTeq® vaccine strains were found to circulate. Immunization in 46.5% of babies in the first year of life during the first year of vaccination and in 69.4% during the second year contributed to reductions in the incidence of rotavirus infection in all age groups and in the number of hospitalized patients aged 0-6 years.