Артериальная гипертензия: возможные патогенетические механизмы хронической ишемии мозга
- Авторы: Баринов Э.Ф1, Фабер Т.И1, Сохина В.С1
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Учреждения:
- Донецкий национальный медицинский университет им. М. Горького
- Выпуск: Том 31, № 9 (2020)
- Страницы: 5-10
- Раздел: Статьи
- URL: https://journals.eco-vector.com/0236-3054/article/view/114283
- DOI: https://doi.org/10.29296/25877305-2020-09-01
- ID: 114283
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Аннотация
Артериальная гипертензия рассматривается как фактор риска развития хронической ишемии мозга, однако причины этого явления остаются малоизученными. В этой связи обсуждаются роль и взаимодействие симпатоадреналовой и ренин-ангиотензиновой систем организма в нарушении функции комплекса «сосуд-глиянейрон». В статье представлены факты, касающиеся особенностей адренергической регуляции мозгового кровообращения, возможного участия адренорецепторов в когнитивных нарушениях и развитии нейровоспаления. Рассматривается связь ангиотензина-2 с ремоделированием сосудистой стенки и проницаемостью гематоэнцефалического барьера, активацией глиальных клеток. Приведенные данные обосновывают необходимость изучения селективных агонистов a-, ß-адренорецепторов и блокаторов АТ1-рецепторов для лечения пациентов с нарушениями мозгового кровообращения.
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Об авторах
Э. Ф Баринов
Донецкий национальный медицинский университет им. М. Горького
Email: barinov.ef@gmail.com
доктор медицинских наук, профессор Донецк, Украина
Т. И Фабер
Донецкий национальный медицинский университет им. М. Горького
Email: barinov.ef@gmail.com
Донецк, Украина
В. С Сохина
Донецкий национальный медицинский университет им. М. Горького
Email: barinov.ef@gmail.com
Донецк, Украина
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