The importance of metabolic markers in the development of a second ischemic stroke


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Objective. To investigate the relationship between plasma adiponectin (ADN) levels and the rate of a second noncardioembolic ischemic stroke (IS) over a three-year period Subjects and methods. The cohort observational study covered 206 patients who had experienced a first noncardioembolic IS, explored the clinical and metabolic parameters of the participants, and assessed the frequency and date of onset of a secondary IS using the Cutler-Ederer and Kaplan-Meier methods according to AND concentrations. Fasting plasma ADN concentrations (pg/ml) were determined using the BioVendor kits (Sweden) on a third-generation Reader UNIPLAN-9213 microplate photometer (PIKON, Russia). Results. The analysis of the frequency and date of onset of a second noncardioembolic IS over a three-year period showed an increased risk of its development in patients with low ADN levels (<7 pg/ml). Conclusion. The patients with a low ADN level are at a high risk for a second noncardioembolic IS.

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作者简介

V. Shishkova

Center for Speech Pathology and Neurorehabilitation, Moscow Healthcare Department; A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia

Email: veronika-1306@mail.ru

T. Adasheva

A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia

L. Stakhovskaya

N.I. Pirogov Russian National Research Medical University

参考

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